Plasticity-augmented psychotherapy for refractory depressive and anxiety disorders

Choi, Kwang Yeon; Kim, Yong Ku

doi:10.1016/j.pnpbp.2016.04.003

Cited by 8 publications

(3 citation statements)

References 206 publications

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“…The author previously published a review article that comprehensively explained in detail the theoretical background of combining valproate and CBT. 50 Here, the theoretical background of valproate and CBT is briefly described in the following sections (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…Memory reconsolidation is a phenomenon observed in various categories of memory, including emotional memory, in both animals and humans and explains the behavioral changes that occur during psychotherapy. 50 The memory is strength-ened, weakened, or updated in response to environmental stimuli immediately after memory recall, a process known as memory reconsolidation. The counterpart of memory reconsolidation is memory consolidation immediately following memory acquisition.…”

Section: Reconsolidation Updating and Psychological Treatmentmentioning

confidence: 99%

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Valproate Adjuvant Cognitive Behavioral Therapy in Panic Disorder Patients With Comorbid Bipolar Disorder: Case Series and Review of the Literature

Choi

2022

Psychiatry Investig

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Anxiety disorders are the most common comorbid psychiatric disorders in patients with bipolar disorder. Managing anxiety symptoms in comorbid conditions is challenging and has received little research interest. The findings from preclinical research on fear conditioning, an animal model of anxiety disorder, have suggested that memory reconsolidation updating (exposure-based therapy) combined with valproate might facilitate the amelioration of fear memories. Here, three cases of successful amelioration of agoraphobia and panic symptoms through valproate adjuvant therapy for cognitive behavioral therapy in patients who failed to respond to two to three consecutive standard pharmacotherapy trials over several years are described. To the best of the author’s knowledge, this is the first attempt to combine CBT with valproate in patients with panic disorder, agoraphobia, and comorbid bipolar disorder. Additionally, the background preclinical research on this combination therapy based on the reconsolidation-updating mechanism, the inhibition of histone deacetylase 2, and critical period reopening, off-label use of valproate in panic disorder, plasticity-augmented psychotherapy, and how to combine valproate with CBT is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Reconsolidation Updating and Psychological Treatmentmentioning

confidence: 99%

Valproate Adjuvant Cognitive Behavioral Therapy in Panic Disorder Patients With Comorbid Bipolar Disorder: Case Series and Review of the Literature

Choi

2022

Psychiatry Investig

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“…The aims of pharmacotherapy for PD may be to improve learning during CBT, which targets plasticity in cortical structures and has been proven to be effective in both rodents and humans. The use of pharmacotherapy together with D-cycloserine resulted in reductions in major acrophobic symptoms in a successful example of combination therapy [17,18,123].…”

Section: Discussionmentioning

confidence: 99%

A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder

Park

Kim

2019

Psychiatry Investig

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To conceptualize a novel bio-psychosocial-behavioral treatment model of panic disorder (PD), it is necessary to completely integrate behavioral, psychophysiological, neurobiological, and genetic data. Molecular genetic research on PD is specifically focused on neurotransmitters, including serotonin, neuropeptides, glucocorticoids, and neurotrophins. Although pharmacological interventions for PD are currently available, the need for more effective, faster-acting, and more tolerable pharmacological interventions is unmet. Thus, glutamatergic receptor modulators, orexin receptor antagonists, corticotrophin-releasing factor 1 receptor antagonists, and other novel mechanism-based anti-panic therapeutics have been proposed. Research on the neural correlates of PD is focused on the dysfunctional “cross-talk” between emotional drive (limbic structure) and cognitive inhibition (prefrontal cortex) and the fear circuit, which includes the amygdala-hippocampus-prefrontal axis. The neural perspective regarding PD supports the idea that cognitive-behavioral therapy normalizes alterations in top-down cognitive processing, including increased threat expectancy and attention to threat. Consistent with the concept of “personalized medicine,” it is speculated that Research Domain Criteria can enlighten further treatments targeting dysfunctions underlying PD more precisely and provide us with better definitions of moderators used to identify subgroups according to different responses to treatment. Structuring of the “negative valence systems” domain, which includes fear/anxiety, is required to define PD. Therefore, targeting glutamate- and orexin-related molecular mechanisms associated with the fear circuit, which includes the amygdala-hippocampus-prefrontal cortex axis, is required to define a novel bio-psychosocial-behavioral treatment model of PD.

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Integrated Approaches for Treatment-Resistant Psychiatric Disorders

Park

Kim

2018

Treatment Resistance in Psychiatry

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Plasticity-augmented psychotherapy for refractory depressive and anxiety disorders

Cited by 8 publications

References 206 publications

Valproate Adjuvant Cognitive Behavioral Therapy in Panic Disorder Patients With Comorbid Bipolar Disorder: Case Series and Review of the Literature

Valproate Adjuvant Cognitive Behavioral Therapy in Panic Disorder Patients With Comorbid Bipolar Disorder: Case Series and Review of the Literature

A Novel Bio-Psychosocial-Behavioral Treatment Model of Panic Disorder

Integrated Approaches for Treatment-Resistant Psychiatric Disorders

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