Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium–pilocarpine

Feng, Li; Li, Aiping; Wang, Meiping; Sun, Danni; Wang, Yelan; Long, Lili; Xiao, Bo

doi:10.1007/s00701-013-1836-4

Cited by 4 publications

(2 citation statements)

References 38 publications

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“…AIS plasticity was originally discovered in excitatory neurons (Grubb & Burrone, ; Kuba, Oichi, & Ohmori, ), but recently it has also been reported in a subpopulation of dopaminergic inhibitory neurons of the rodent's olfactory bulb (Chand, Galliano, Chesters, & Grubb, ). AIS plasticity has been shown to occur during postnatal development in mouse visual cortex (Gutzmann et al, ) and monkey prefrontal cortex (Fish, Hoftman, Sheikh, Kitchens, & Lewis, ), and also in pathophysiological conditions such as epilepsy (Feng et al, ; Harty et al, ) and stroke (Hinman, Rasband, & Carmichael, ).…”

Section: Introductionmentioning

confidence: 99%

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

Nozari

Suzuki

Rosa

et al. 2016

Developmental Psychobiology

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Plasticity of the axon initial segment (AIS) is a newly discovered type of structural plasticity that regulates cell excitability. AIS plasticity has been reported to happen during normal development of neocortex and also in a few pathological conditions involving disruption of the inhibition/excitation balance. Here we report on the impact of early environmental interventions on structural plasticity of AIS in the mouse neocortex. C57BL/6 mice were raised

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Section: Introductionmentioning

confidence: 99%

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

Nozari

Suzuki

Rosa

et al. 2016

Developmental Psychobiology

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“…The method of modeling was conducted in the same manner as our previous work (34,35). Briefly, the experimental group was treated with lithium chloride (125 mg/kg, i.p., Sigma-Aldrich, USA), and 18-20 h later, methyl atropine bromide (1 mg/kg, i.p.…”

Section: Seizure Model and Groupsmentioning

confidence: 99%

The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy

Zhou

Huang

et al. 2020

Ann Transl Med

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Background: The recurrence and drug resistance of temporal lobe epilepsy (TLE) has been ceaselessly challenging scientists and epilepsy experts. There has been an accumulation of evidence linking the dysregulation of postsynaptic proteins etiology and the pathology of epilepsy. For example, NMDA receptors, AMPA receptors, and metabotropic glutamate receptors (mGluRs). Furthermore, our earlier proteomic analysis proved there to be differential expressions of cytoskeletons like microtubules among rat groups. These differential expressions were shown in TLE-spontaneous recurrent seizures (TLE-SRS), TLE without SRS (TLE-NSRS) and control groups. Therefore, we aimed to understand how the microtubule system of the hippocampal postsynaptic density (PSD) regulates the development of TLE.Methods: In this study, a pilocarpine-induced Sprague-Dawley rat TLE model were used, and Western blot, Nissl staining, and the immunoelectron microscopic method were utilized to determine the dynamic change of microtubules (α-and β-tubulin) in PSD and the extent of hippocampal neuron loss respectively in acute SE, and latent and chronic (spontaneous seizures) periods. Animal models were then stereotactically treated using colchicine, a microtubule depolymerizer, and paclitaxel, a microtubule polymerization agent, after each animal's acute SE period so as to further explore the function of PSD microtubules.Results: Our study revealed 3 principal findings. One, both α-and β-tubulin were decreased from the 3 rd to the 30 th day (lowest at the 7 th day) in the seizure group compared with the controls. Two, both α-and β-tubulin were found to be more downregulated in the TLE-SRS and the TLE-NSRS group than in the control group (especially in the TLE-SRS group). The same trend was also noticed for hippocampal neuron loss. Three, the paclitaxel lowered the chronic SRS rate and increased the expression of PSD β-tubulin in the hippocampus.Conclusions: Altogether, these results indicate that the microtubule system of PSD may play an essential role in the development and recurrence of epilepsy, and it may be used as a new target for the prevention and treatment of this refractory disease.

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Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease

Ureña-Torres

Vervloet²,

Mazzaferro

et al. 2018

Clinical Kidney Journal

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Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during ‘The Parathyroid Day in Chronic Kidney Disease’ CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)–Klotho axis, as well as on parathyroid glands imaging. The skeletal action of PTH in early CKD stages to the steadily increasing activation of the often downregulated PTH receptor type 1 has been critically reviewed, emphasizing that therapeutic strategies to decrease PTH levels at these stages might not be recommended. The effects of PTH on the central nervous system, in particular cognitive functions, and on the cardiovascular system are revised, and the reliability and exchangeability of second- and third-generation PTH immunoassays discussed. The article also reviews the different circulating biomarkers used for the diagnosis and monitoring of CKD-MBD, including PTH and alkaline phosphatases isoforms. Moreover, it presents an update on the control of SHPT by vitamin D compounds, old and new calcimimetics, and parathyroidectomy. Finally, it covers the latest insights on the persistence and de novo occurrence of SHPT in renal transplant recipients.

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Plasticity at axon initial segment of hippocampal CA3 neurons in rat after status epilepticus induced by lithium–pilocarpine

Abstract: Nav1.6 and ankyrin G may participate in the plastic changes in the AIS of hippocampus CA3 neurons after PISE and play potential roles in epileptogenesis by regulating neuronal excitability.

Cited by 4 publications

References 38 publications

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

The impact of early environmental interventions on structural plasticity of the axon initial segment in neocortex

The study of microtubule dynamics and stability at the postsynaptic density in a rat pilocarpine model of temporal lobe epilepsy

Novel insights into parathyroid hormone: report of The Parathyroid Day in Chronic Kidney Disease

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