Abstract:The contamination of intravenously administered fluid with foreign material has always been of major concern, but the in-vivo impact of silicone embolisation from administration of fluid via a peristaltic finger pump (PFP) has not previously been assessed. To determine whether silicone particles enter the lungs and to review the histological response, 10 rabbits received an IV infusion of 0.9% saline at 10 ml/kg per hour over a 72-h period, via an IVAC 591 PFP. The lungs were analysed for silicone particles wi… Show more
“…1 These foreign matters are a serious threat to the lives of consumers. 2 Therefore, there is an urgent need for strict quality control of foreign matters generated during the oral liquid production process.…”
Chinese herbal oral liquid can leach a variety of effective ingredients from herbs and has become a major drug for clinical application. However, it is easy to produce or introduce foreign matters that are very faint in the automatic filling production process. To solve the challenge of low accuracy of faint foreign matter detection, in this paper, we proposed a salient-based anomaly detection method which is fuses visual saliency with dual-spectral saliency (VDS) for the hyperspectral herbal oral liquid. Specifically, we first select the most discriminative bands via the band selection method to generate the pseudo-color map. Subsequently, the histogram-based contrast method is introduced to select the saliency feature map with the largest variance of color features, while fusing the multi-scale gradient features to obtain the preliminary vision-based anomaly detection map. After that, the spectral angles and spectral Euclidean distances are calculated separately based on the oral liquid hyperspectral images to fused into dual-spectral saliency maps. Finally, the dual-spectral saliency map is employed to suppress the background information of the preliminary anomaly detection map. The experimental results show that our proposed method outperforms the state-of-the-art anomaly detection methods, which accurately and quickly achieve the detection of faint foreign matter in the hyperspectral herbal oral liquid. It will accelerate the process of automated filling production lines for oral liquid in the pharmaceutical industry.
“…1 These foreign matters are a serious threat to the lives of consumers. 2 Therefore, there is an urgent need for strict quality control of foreign matters generated during the oral liquid production process.…”
Chinese herbal oral liquid can leach a variety of effective ingredients from herbs and has become a major drug for clinical application. However, it is easy to produce or introduce foreign matters that are very faint in the automatic filling production process. To solve the challenge of low accuracy of faint foreign matter detection, in this paper, we proposed a salient-based anomaly detection method which is fuses visual saliency with dual-spectral saliency (VDS) for the hyperspectral herbal oral liquid. Specifically, we first select the most discriminative bands via the band selection method to generate the pseudo-color map. Subsequently, the histogram-based contrast method is introduced to select the saliency feature map with the largest variance of color features, while fusing the multi-scale gradient features to obtain the preliminary vision-based anomaly detection map. After that, the spectral angles and spectral Euclidean distances are calculated separately based on the oral liquid hyperspectral images to fused into dual-spectral saliency maps. Finally, the dual-spectral saliency map is employed to suppress the background information of the preliminary anomaly detection map. The experimental results show that our proposed method outperforms the state-of-the-art anomaly detection methods, which accurately and quickly achieve the detection of faint foreign matter in the hyperspectral herbal oral liquid. It will accelerate the process of automated filling production lines for oral liquid in the pharmaceutical industry.
This study demonstrates that a large number of particles can be administered during parenteral multidrug infusion. The choice of drug concentration and/or the type of infusion set may reduce this. Further studies are required to evaluate adverse clinical effects.
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