Plastic optical fiber immunosensor for fast detection of sulfate-reducing bacteria

Lopes, Rafaela N.; Rodrigues, Domingos M. C.; Allil, Regina C.; Werneck, Marcelo Martins

doi:10.1016/j.measurement.2018.04.088

Cited by 18 publications

(18 citation statements)

References 16 publications

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“…Due to the high numerical aperture (NA), proper curvature, and secure processing, plastic optical fibers (POFs) have attracted significant attention from researchers and have been widely used in different applications such as gas detection, biomedical, and other fields [1][2][3][4]. The D-shaped [5,6], tapered [7], U-shaped [8], and twisted macro-bend coupling structures [9] have been fabricated and characterized.…”

Section: Introductionmentioning

confidence: 99%

Ethanol Gas Sensitivity Sensor Based on Roughened POF Taper of Modified Polypyrrole Films

Liu

Hou

2020

Sensors

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The three polypyrrole (PPy) films with different mixture ratios, namely PPy1, PPy2, and PPy3, were synthesized by chemical oxidation with pyrrole and ferric chloride (FeCl3). The roughened plastic optical fiber (POF) taper assembled PPy films (POF-PPy1, POF-PPy2, and POF-PPy3) were facilely prepared and bent U shape structure for testing ethanol gas at room temperature. The morphologies of the PPy films and the roughened POF taper were studied using electron microscopy. The effect of the three PPy films on the gas response was investigated and the results showed that the POF-PPy2 exhibited a high sensitivity of 5.08 × 10−5 dB/ppm. The detection limit of the sensor was 140 ppm and its response and recovery times were 5 s and 8 s, respectively. The results also showed that as the bending radius decreased, the response and recovery times gradually shortened, while the output power increased. In addition, the proposed sensor has advantages of a low cost and simple structure.

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Section: Introductionmentioning

confidence: 99%

Ethanol Gas Sensitivity Sensor Based on Roughened POF Taper of Modified Polypyrrole Films

Liu

Hou

2020

Sensors

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“…Lastly, the biofunctionalization procedure ends with a passivation step. The most common passivating agents are bovine serum albumin (BSA) [13,31,47,54,[95][96][97][98] and poly(ethylene glycol) (PEG) [99]. These reagents are commonly implemented to reduce the non-specific interactions between the analyte and surface, and also between interferents present in more complex matrixes.…”

Section: Biofunctionalization Strategies For Optical Fiber Immunosensorsmentioning

confidence: 99%

“…Afterwards, the fiber is incubated in HMDA in order to form amine grou the hydrolyzed surface [38,54,99], becoming more hydrophilic. The amine-terminated can be then functionalized with the antibody by direct covalent linkage to the surface GA [99] or using the intermediary Protein A [54], as depicted in Figure 9. Considering the physical adsorption strategy via electrostatic immobilization, as aforementioned, the antibodies possess a negative surface charge at physiological pH conditions, thus the fiber must have a positive surface charge.…”

Section: Plastic Optical Fibermentioning

confidence: 99%

Immunosensing Based on Optical Fiber Technology: Recent Advances

et al. 2021

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The evolution of optical fiber technology has revolutionized a variety of fields, from optical transmission to environmental monitoring and biomedicine, given their unique properties and versatility. For biosensing purposes, the light guided in the fiber core is exposed to the surrounding media where the analytes of interest are detected by different techniques, according to the optical fiber configuration and biofunctionalization strategy employed. These configurations differ in manufacturing complexity, cost and overall performance. The biofunctionalization strategies can be carried out directly on bare fibers or on coated fibers. The former relies on interactions between the evanescent wave (EW) of the fiber and the analyte of interest, whereas the latter can comprise plasmonic methods such as surface plasmon resonance (SPR) and localized SPR (LSPR), both originating from the interaction between light and metal surface electrons. This review presents the basics of optical fiber immunosensors for a broad audience as well as the more recent research trends on the topic. Several optical fiber configurations used for biosensing applications are highlighted, namely uncladded, U-shape, D-shape, tapered, end-face reflected, fiber gratings and special optical fibers, alongside practical application examples. Furthermore, EW, SPR, LSPR and biofunctionalization strategies, as well as the most recent advances and applications of immunosensors, are also covered. Finally, the main challenges and an outlook over the future direction of the field is presented.

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“…Although such an assembly has been employed for the detection of immunoglobulin [170], plastic optical fibre-based sensors in conjunction with liposomal amplifiers show 10 6 times higher sensitivity [172]. Such plastic optical fibres have also enabled rapid pathogen detection in 30 minutes over a wide concentration range (10 4 -10 8 MPN mL −1 ) [173]. EW-based non-enzymatic glucose sensors have been developed using a polyphenylnoronic acid.…”

Section: Evanescent Wave-based Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

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In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

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Plastic optical fiber immunosensor for fast detection of sulfate-reducing bacteria

Cited by 18 publications

References 16 publications

Ethanol Gas Sensitivity Sensor Based on Roughened POF Taper of Modified Polypyrrole Films

Ethanol Gas Sensitivity Sensor Based on Roughened POF Taper of Modified Polypyrrole Films

Immunosensing Based on Optical Fiber Technology: Recent Advances

Recent Progress in Optical Sensors for Biomedical Diagnostics

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