Plastic Change in the Auditory Minimum Threshold Induced by Intercollicular Effects in Mice

Mei, Hui-Xian; Tang, Jia; Fu, Zi-Ying; Cheng, Liang; Chen, Qi‐Cai

doi:10.1155/2016/4195391

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…Generally, because of the existence of numerous inhibitory interneurons, there is a higher proportion of inhibitory interactions than excitatory interactions ( Mei et al, 2013 ). Some papers have reported that the number of neurons inhibited by contralateral neurons was greater than the number of neurons facilitated ( Jen et al, 2002 ; Wu and Jen, 2008 ; Mei et al, 2016 ). However, the proportion of facilitated neurons was reported to be higher than that of inhibited neurons for non-V-shaped TRF neurons ( Orton and Rees, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing

Liu

Peng

et al. 2022

Front. Physiol.

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The inferior colliculus (IC) is a critical centre for the binaural processing of auditory information. However, previous studies have mainly focused on the central nucleus of the inferior colliculus (ICC), and less is known about the dorsal nucleus of the inferior colliculus (ICD). Here, we first examined the characteristics of the neuronal responses in the mouse ICD and compared them with those in the inferior colliculus under binaural and monaural conditions using in vivo loose-patch recordings. ICD neurons exhibited stronger responses to ipsilateral sound stimulation and better binaural summation than those of ICC neurons, which indicated a role for the ICD in binaural hearing integration. According to the abundant interactions between bilateral ICDs detected using retrograde virus tracing, we further studied the effect of unilateral ICD silencing on the contralateral ICD. After lidocaine was applied, the responses of some ICD neurons (13/26), especially those to ipsilateral auditory stimuli, decreased. Using whole-cell recording and optogenetic methods, we investigated the underlying neuronal circuits and synaptic mechanisms of binaural auditory information processing in the ICD. The unilateral ICD provides both excitatory and inhibitory projections to the opposite ICD, and the advantaged excitatory inputs may be responsible for the enhanced ipsilateral responses and binaural summation of ICD neurons. Based on these results, the contralateral ICD might modulate the ipsilateral responses of the neurons and binaural hearing.

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Section: Discussionmentioning

confidence: 99%

Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing

Liu

Peng

et al. 2022

Front. Physiol.

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“…As expected given changes in frequency response areas, stimulation or inactivation in the IC also influences the relationship between firing rate and sound level of neurons in the opposite side, as exemplified by rate-level functions (RLFs). Electrical stimulation can elicit increases or decreases in firing rate, although the majority of neurons were inhibited by stimulation of the contralateral IC (Cheng 2016;Mei 2012). Facilitation was generally only observed with small BF differences whereas inhibition occurred over a wider range of best frequency differences, again raising the possibility of interactions between within and between laminae.…”

Section: Influence Of Commissural Input On Frequency Responses In the Ic V-shaped (A) And Nonv-shaped (B) Response Areas For Single Neuromentioning

confidence: 99%

“…Stimulus-dependent gain control in the IC has been shown to keep neurons within their operating range so maintaining their responsiveness to tones as noise levels increase (Rees and Palmer 1988;Dean et al 2005;Robinson and McAlpine 2009). It is interesting that modulation of commissural activity leads to shifts in the operating ranges of rate-level functions (Mei et al 2012a;Orton and Rees 2014;Mei et al 2016).…”

Section: Figure 6 Near Herementioning

confidence: 99%

Unifying the Midbrain

Rees

Orton

2018

The Oxford Handbook of the Auditory Brainstem

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Commissural fibres interconnecting the two sides of the brain are found at several points along the auditory pathway, thus suggesting their fundamental importance for the analysis of sound. This chapter presents an overview of what is currently known about the anatomy, physiology, and behavioral influences of the commissure of the inferior colliculus (CoIC)—the most prominent brainstem auditory commissure—that reciprocally interconnects the principal nuclei of the auditory midbrain, the inferior colliculi (IC). The primary contribution to the CoIC originates from neurons projecting from one inferior colliculus to the other, with the dorsal cortex and central nucleus providing the most extensive connections. In addition, many ascending and descending auditory centers send projections to the IC via the CoIC, together with diverse sources located outside the classically defined auditory pathway. The degree of interconnection between the two ICs suggests they function as a single entity. Recent in vivo evidence has established that CoIC projections modulate the neural representation of sound frequency, level, and location in the IC, thus indicating an important role for the CoIC in auditory processing. However, there is limited evidence for the influence of the CoIC on auditory behavior. This, together with the diversity of sources projecting via the CoIC, suggest unknown roles that warrant further exploration.

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“…Pharmacological studies have proven that initial IPSPs result from single synapse inhibition, and subsequent IPSPs are likely due to coinhibition of multiple synapses [13]. Using focal drug injection [4,16], electrical stimulation [17][18][19][20], and freezing one side of the IC [21][22][23], in vivo studies observed changes in response characteristics of the IC neurons located on the other side. These studies have proven that binaural IC interactions have considerable influence on the firing rate of IC neurons.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Neuron Latency Modulated by Bilateral Inferior Collicular Interactions Using Whole-Cell Patch Clamp Recording in Brain Slices

Han

Yao

et al. 2021

Neural Plasticity

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As the final level of the binaural integration center in the subcortical nucleus, the inferior colliculus (IC) plays an essential role in receiving binaural information input. Previous studies have focused on how interactions between the bilateral IC affect the firing rate of IC neurons. However, little is known concerning how the interactions within the bilateral IC affect neuron latency. In this study, we explored the synaptic mechanism of the effect of bilateral IC interactions on the latency of IC neurons. We used whole-cell patch clamp recordings to assess synaptic responses in isolated brain slices of Kunming mice. The results demonstrated that the excitation-inhibition projection was the main projection between the bilateral IC. Also, the bilateral IC interactions could change the reaction latency of most neurons to different degrees. The variation in latency was related to the type of synaptic input and the relative intensity of the excitation and inhibition. Furthermore, the latency variation also was caused by the duration change of the first subthreshold depolarization firing response of the neurons. The distribution characteristics of the different types of synaptic input also differed. Excitatory-inhibitory neurons were widely distributed in the IC dorsal and central nuclei, while excitatory neurons were relatively concentrated in these two nuclei. Inhibitory neurons did not exhibit any apparent distribution trend due to the small number of assessed neurons. These results provided an experimental reference to reveal the modulatory functions of bilateral IC projections.

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Plastic Change in the Auditory Minimum Threshold Induced by Intercollicular Effects in Mice

Cited by 4 publications

References 31 publications

Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing

Bilateral Interactions in the Mouse Dorsal Inferior Colliculus Enhance the Ipsilateral Neuronal Responses and Binaural Hearing

Unifying the Midbrain

Investigation of Neuron Latency Modulated by Bilateral Inferior Collicular Interactions Using Whole-Cell Patch Clamp Recording in Brain Slices

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