Plastic bronchitis associated with influenza A virus in children with asthma

Wang, Yanyan; An, Shuhua

doi:10.1177/03000605211065370

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…And no differences were found in the incidence of fever between severe asthma children with or without recurrent MLS, suggesting that MP infection might not be the cause of recurrent MLS. Viral infection can also cause mucus plug and atelectasis, especially influenza virus ( 30 , 31 ). In the present study, two cases with non-recurrent MLS had viral infections with influenza virus in only one case.…”

Section: Discussionmentioning

confidence: 99%

Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns

Feng

Yu²,

Liu³

et al. 2023

Front. Pediatr.

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BackgroundMiddle lobe syndrome (MLS) is a complication of childhood asthma. This study aimed to compare the clinical features and lung function between asthmatic children with recurrent MLS and transient right middle lobe (RML) and/or lingula atelectasis.MethodsThis study retrospectively analyzed asthmatic children with RML and/or lingula atelectasis between 2010 and 2020 using data from the pediatric pulmonary department. According to the episodes of atelectasis, children were divided into recurrent (≥2 episodes) and non-recurrent (only 1 episode) MLS groups, to compare clinical features and lung function. Spirometry during acute asthma exacerbation and stable stages were recorded, and variations were calculated.ResultsA total of 35 children with asthma and RML and/or lingula atelectasis were included, 15 of whom had recurrent MLS. The recurrent MLS group had a higher proportion of girls, infections, family allergy history, severe asthma, severe exacerbation, and higher levels of total IgE than the non-recurrent MLS group (P < 0.05). The recurrent MLS group had a significantly higher % predicted and z-scores for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), a greater proportion of high FEV1 and higher variations in FEV1 and FVC than that in the non-recurrent group (P < 0.05). After excluding children with mild to moderate asthma in the recurrent MLS group, the differences in clinical features disappeared, but the results regarding lung function remained similar, when compared to severe asthma patients without RML and/or lingula atelectasis.ConclusionsChildhood asthma with recurrent MLS has more frequent severe asthma and exacerbation but high lung function and variations.

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Section: Discussionmentioning

confidence: 99%

Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns

Feng

Yu²,

Liu³

et al. 2023

Front. Pediatr.

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“…Respiratory viruses including influenza are a major cause of PB. 18 , 19 However, the exact incidence of PB in children with infected influenza infection has not yet been fully studied. Influenza belongs to the enveloped Orthomyxoviridae viruses and can be divided into types A, B, C and D. Both influenza A and B viruses can be further divided into subtypes based on the differential expression of the two antigens against hemagglutinin (H) and neuraminidase (N).…”

Section: Discussionmentioning

confidence: 99%

Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination

Huang¹,

Wu²,

Chengqian³

et al. 2023

IDR

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Background Plastic bronchitis (PB) is a rare and severe lung disease. It can be triggered by influenza virus infection, which is a common respiratory infection in children. Bronchoscopy can aid in the early detection and treatment of PB. However, the outcomes and risk for PB development in pediatric patients with influenza virus infection are not fully understood. Methods Data from 321 children diagnosed with influenza virus pneumonia who underwent bronchoscopy examinations between 1st January, 2009 and 31st December, 2020 were retrospectively analyzed to assess the outcomes and risk factors associated with PB development. Results This study included 97 girls and 224 boys with influenza virus pneumonia with a median age of 42 months. Among them, 36 patients (11.2%) were categorized as having PB based on bronchoscopy findings. PB patients had significantly longer fever durations ( p =0.010) and higher risks of developing severe conditions including respiratory failure ( p <0.001), acute respiratory distress syndrome ( p <0.001), and air-leak syndrome ( p <0.001) compared to non-PB patients. Conventional treatment including the use of neuraminidase inhibitors and antibiotics did not differ between the PB and non-PB patients, but PB patients required more anti-inflammatory treatment ( p =0.019) and ventilator support ( p <0.001). Combined univariate and multivariate analyses suggested that radiographic findings, including mediastinal emphysema ( p =0.012) and lung consolidation ( p =0.012), as well as increased levels of neutrophils ( p =0.026), aspartate aminotransferase ( p =0.004), and lactate dehydrogenase ( p <0.001), were identified as risk factors for PB development in patients with influenza virus pneumonia. Although PB patients required more intensive care and had longer hospital stays, they all recovered well after treatment. Conclusion Influenza virus infection is linked to PB development in children. Identifying risk factors and early intervention such as bronchoscopy can improve the prognosis of children with PB.

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“…The high bioactivity of the bioprocessed combinations against foodborne pathogens and hangover biomarkers in rodents are most likely the result of the formation of new bioactive compounds during the fermentation process, an aspect that merits further study. Moreover, although asthma does not seem to increase risk of COVID-19 infection, it would also be of interest to determine if the bioprocessed E. cava food formulation that protected the lungs of mice against inflammatory allergic asthma might also help ameliorate the acute respiratory syndrome associated with the viral infection [31][32][33] as well as allergic manifestations associated with foods [34][35][36][37][38] and drugs [39].…”

Section: Discussionmentioning

confidence: 99%

Edible algae (Ecklonia cava) bioprocessed with mycelia of shiitake (Lentinula edodes) mushrooms in liquid culture and its isolated fractions protect mice against allergic asthma

Lee

Jang²,

Hwang³

et al. 2022

BMC Complement Med Ther

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Background Ecklonia cava is an edible marine brown alga harvested from the ocean that is widely consumed in Asian countries as a health-promoting medicinal food The objective of the present study is to evaluate the anti-asthma mechanism of a new functional food produced by bioprocessing edible algae Ecklonia cava and shiitake Lentinula edodes mushroom mycelia and isolated fractions. Methods We used as series of methods, including high performance liquid chromatography, gas chromatography, cell assays, and an in vivo mouse assay to evaluate the asthma-inhibitory effect of Ecklonia cava bioprocessed (fermented) with Lentinula edodes shiitake mushroom mycelium and its isolated fractions in mast cells and in orally fed mice. Results The treatments inhibited the degranulation of RBL-2H3 cells and immunoglobulin E (IgE) production, suggesting anti-asthma effects in vitro. The in vitro anti-asthma effects in cells were confirmed in mice following the induction of asthma by alumina and chicken egg ovalbumin (OVA). Oral administration of the bioprocessed Ecklonia cava and purified fractions suppressed the induction of asthma and was accompanied by the inhibition of inflammation- and immune-related substances, including eotaxin; thymic stromal lymphopoietin (TSLP); OVA-specific IgE; leukotriene C 4 (LTC4); prostaglandin D2 (PGD 2 ); and vascular cell adhesion molecule-1 (VCAM-1) in bronchoalveolar lavage fluid (BALF) and other fluids and organs. Th2 cytokines were reduced and Th1 cytokines were restored in serum, suggesting the asthma-induced inhibitory effect is regulated by the balance of the Th1/Th2 immune response. Serum levels of IL-10, a regulatory T cell (Treg) cytokine, were increased, further favoring reduced inflammation. Histology of lung tissues revealed that the treatment also reversed the thickening of the airway wall and the contraction and infiltration of bronchial and blood vessels and perialveolar inflammatory cells. The bioprocessed Ecklonia cava/mushroom mycelia new functional food showed the highest inhibition as compared with commercial algae and the fractions isolated from the bioprocessed product. Conclusions The in vitro cell and in vivo mouse assays demonstrate the potential value of the new bioprocessed formulation as an anti-inflammatory and anti-allergic combination of natural compounds against allergic asthma and might also ameliorate allergic manifestations of foods, drugs, and viral infections.

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Plastic bronchitis associated with influenza A virus in children with asthma

Cited by 7 publications

References 14 publications

Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns

Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns

Outcomes and Risk Factor Analysis of Plastic Bronchitis Among 321 Children with Influenza Pneumonia After Bronchoscopy Examination

Edible algae (Ecklonia cava) bioprocessed with mycelia of shiitake (Lentinula edodes) mushrooms in liquid culture and its isolated fractions protect mice against allergic asthma

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