Plasmonic titanium nitride nanoparticles for in vivo photoacoustic tomography imaging and photothermal cancer therapy

He, Wenya; Ai, Kelong; Jiang, Chunhuan; Li, Yuanyuan; Song, Xiaolan; Lu, Lehui

doi:10.1016/j.biomaterials.2017.04.007

Cited by 153 publications

(115 citation statements)

References 51 publications

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“…[21] This was attributed to the slight oxidation on the surface of Ta NPs, resulting in the formation of ultrast able tantalum pentoxide coating to prevent further oxidation as previously reported. [21b,22] The abundant surface oxygenic groups were essential for silanecoupling reaction, [23] in which silane was converted into silanol form to react with surface oxygenic groups of Ta NPs. [23,24] Based on the above results, the silanecoupling reaction on the surface of Ta NPs can be repre sented by Equation (1)…”

Section: Fabrication and Characterization Of Pegylated Ta Npsmentioning

confidence: 99%

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Miao

Liu

Wang

et al. 2019

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Elemental tantalum is a well‐known biomedical metal in clinics due to its extremely high biocompatibility, which is superior to that of other biomedical metallic materials. Hence, it is of significance to expand the scope of biomedical applications of tantalum. Herein, it is reported that tantalum nanoparticles (Ta NPs), upon surface modification with polyethylene glycol (PEG) molecules via a silane‐coupling approach, are employed as a metallic photoacoustic (PA) contrast agent for multiwavelength imaging of tumors. By virtue of the broad optical absorbance from the visible to near‐infrared region and high photothermal conversion efficiency (27.9%), PEGylated Ta NPs depict high multiwavelength contrast capability for enhancing PA imaging to satisfy the various demands (penetration depth, background noise, etc.) of clinical diagnosis as needed. Particularly, the PA intensity of the tumor region postinjection is greatly increased by 4.87, 7.47, and 6.87‐fold than that of preinjection under 680, 808, and 970 nm laser irradiation, respectively. In addition, Ta NPs with negligible cytotoxicity are capable of eliminating undesirable reactive oxygen species, ensuring the safety for biomedical applications. This work introduces a silane‐coupling strategy for the surface engineering of Ta NPs, and highlights the potential of Ta NPs as a biocompatible metallic contrast agent for multiwavelength photoacoustic image.

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Section: Fabrication and Characterization Of Pegylated Ta Npsmentioning

confidence: 99%

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Miao

Liu

Wang

et al. 2019

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“…[21] Meanwhile, black phosphorus quantum dots (BPQDs), which display an excellent NIR photothermal performance andb iocompatibility have emerged. [27] For example, Polylysine (PL) and Polyethyleneg lycol (PEG) modified BPQDs have been used to treat breast tumorst hrough PTT with photoacoustic imaging (PAI). [27,28] These unique properties of BPQDs make it ap romising drug delivery system for multimodal therapy.T herefore, BPQDs can be to serve as capping/ switching materials or photothermal agents for NCs with porousstructures.…”

Section: Introductionmentioning

confidence: 99%

Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe₃O₄ Nanocapsules (BPQDs@ss‐Fe₃O₄@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

Zhang

Wang

et al. 2018

Chemistry A European J

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Combination therapies for tumors based on different therapeutic approaches should try to improve treatment efficacy, but also to reduce side-effects related to the exogenous stimulus and premature release. In the following study, we established and validated a pH/near-infrared (NIR)/glutathione (GSH)/-responsive multifunctional disulfide cross-linked Fe O @C nanocarriers (ss-Fe O @C NCs) with black phosphorus quantum dots (BPQDs) as a capping agent. BPQDs and carbon shell of Fe O @C nanoparticles (NPs) were used as a photothermal agents, while the inner empty nucleus that allows for a high drug payload served as an effective drug carrier. These magnetofluorescent BPQDs@DOX@ss-Fe O @C NPs were conjugated with a targeting aptamer (epidermal growth factor receptor: EGFR), denoted as BPQDs@DOX@ss-Fe O @C-EGFR NPs, for targeting dual modal magnetic resonance (MR)/fluorescence imaging. The synthetic NCs showed that drug release was dependent on pH, near-infrared (NIR), and intracellular GSH levels, with minimum systemic release in the blood and maximum drug release within the tumors. Also, the photothermal effect resulting from the Fe O @C NPs and BPQDs upon application to NIR light caused a rapid rise in local temperature, which accounted for the highest enhancement of cell cytotoxicity. Thus, a theranostic system consisting of BPQDs@DOX@ss-Fe O @C-EGFR NPs is shown to generate excellent advantages in combined chemotherapy/photothermal therapy (PTT) with minimal side effects.

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“…Using strong oxidizing agents, oxygenated functionalities in the graphene structure can produce graphene oxide (GO), which is hydrophilic and more biocompatible. [73][74][75][76][77][78] Here we enumerate a probe with the highest availability of optical-thermo conversion by using GO and dyes via -stacking interactions. The attached dye molecules on GO can selectively absorb light energy due to their narrow absorption spectral pro¯le.…”

Section: Graphene Oxide In Paimentioning

confidence: 99%

Photoacoustic molecular imaging with functional nanoparticles

Qin

2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging (PAI) breaks through the optical di®usion limit by making use of the PA e®ect. By converting incident photons into ultrasonic waves, PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging modality. This imaging modality has now shown potential for molecular imaging, which enables visualization of biological processes with systemically introduced functional nanoparticles. In the current review, the potentials of di®erent optical nanoprobes as PAI contrast agents were elucidated and discussed.

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Plasmonic titanium nitride nanoparticles for in vivo photoacoustic tomography imaging and photothermal cancer therapy

Cited by 153 publications

References 51 publications

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe₃O₄ Nanocapsules (BPQDs@ss‐Fe₃O₄@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

Photoacoustic molecular imaging with functional nanoparticles

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Plasmonic titanium nitride nanoparticles for in vivo photoacoustic tomography imaging and photothermal cancer therapy

Cited by 153 publications

References 51 publications

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

PEGylated Tantalum Nanoparticles: A Metallic Photoacoustic Contrast Agent for Multiwavelength Imaging of Tumors

Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe3O4 Nanocapsules (BPQDs@ss‐Fe3O4@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy

Photoacoustic molecular imaging with functional nanoparticles

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Black Phosphorus Quantum Dots Gated, Carbon‐Coated Fe₃O₄ Nanocapsules (BPQDs@ss‐Fe₃O₄@C) with Low Premature Release Could Enable Imaging‐Guided Cancer Combination Therapy