Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Recent advances of plasmonic nanoparticles include fascinating developments in the fields of energy, catalyst chemistry, optics, biotechnology, and medicine. The plasmonic photothermal properties of metallic nanoparticles are of enormous interest in biomedical fields because of their strong and tunable optical response and the capability to manipulate the photothermal effect by an external light source. To date, most biomedical applications using photothermal nanoparticles have focused on photothermal therapy; however, to fully realize the potential of these particles for clinical and other applications, the fundamental properties of photothermal nanoparticles need to be better understood and controlled, and the photothermal effect‐based diagnosis, treatment, and theranostics should be thoroughly explored. This Progress Report summarizes recent advances in the understanding and applications of plasmonic photothermal nanoparticles, particularly for sensing, imaging, therapy, and drug delivery, and discusses the future directions of these fields.

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Section: Sensingmentioning

confidence: 99%

“…[8] Copyright 2012, Springer Nature. [92] In their method, Au bipyramid nanoparticles (AuBPs) were evenly dispersed in solution and acted as heating nanoreactors to absorb the photonic energy and convert it to heat energy. The data plots show normalized fluorescence emission as a function of streptavidin concentration.…”

Section: Sensingmentioning

confidence: 99%

Plasmonic Photothermal Nanoparticles for Biomedical Applications

2019

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“…24 It is worth noting that the plasmonic nanoparticles normally exhibit large optical cross sections and the absorbed light can be nonradiatively relaxed resulting in a significant heating energy. 25,26 The converted plasmonic photothermal (PPT) heat energy, also known as the thermoplasmonic effect is highly localized near the nanoparticles, which can be used as a stable in situ heat source for controllable and uniform thermal processing. 26−29 In this work, we developed a dual-functional LSPR biosensor through combining the photothermal effect and plasmonic sensing transduction for SARS-CoV-2 viral nucleic acid detection.…”

mentioning

confidence: 99%

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection

et al. 2020

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The ongoing outbreak of the novel coronavirus disease has spread globally and poses a threat to public health in more than 200 countries. Reliable laboratory diagnosis of the disease has been one of the foremost priorities for promoting public health interventions. The routinely used reverse transcription polymerase chain reaction (RT-PCR) is currently the reference method for COVID-19 diagnosis. However, it also reported a number of false-positive or -negative cases, especially in the early stages of the novel virus outbreak. In this work, a dual-functional plasmonic biosensor combining the plasmonic photothermal (PPT) effect and localized surface plasmon resonance (LSPR) sensing transduction provides an alternative and promising solution for the clinical COVID-19 diagnosis. The two-dimensional gold nanoislands (AuNIs) functionalized with complementary DNA receptors can perform a sensitive detection of the selected sequences from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through nucleic acid hybridization. For better sensing performance, the thermoplasmonic heat is generated on the same AuNIs chip when illuminated at their plasmonic resonance frequency. The localized PPT heat is capable to elevate the in situ hybridization temperature and facilitate the accurate discrimination of two similar gene sequences. Our dual-functional LSPR biosensor exhibits a high sensitivity toward the selected SARS-CoV-2 sequences with a lower detection limit down to the concentration of 0.22 pM and allows precise detection of the specific target in a multigene mixture. This study gains insight into the thermoplasmonic enhancement and its applicability in the nucleic acid tests and viral disease diagnosis.

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“…Surfactant stabilization is a powerful technique for mixing and dispersing immiscible hydrophobic nanoparticles within a continuous aqueous phase . As we demonstrated in a previous publication, dispersions of nanoparticles coated with an alkyl‐SAM can be functionalized with ionic as well as zwitterionic surfactants in water.…”

Section: Resultsmentioning

confidence: 94%

Manufacturing Nanoparticles with Orthogonally Adjustable Dispersibility in Hydrocarbons, Fluorocarbons, and Water

et al. 2018

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We describe a universal wet‐chemical shell‐by‐shell coating procedure resulting in colloidal titanium dioxide (TiO2) and iron oxide (Fe3O4) nanoparticles with dynamically and reversibly tunable surface energies. A strong covalent surface functionalization is accomplished by using long‐chained alkyl‐, triethylenglycol‐, and perfluoroalkylphosphonic acids, yielding highly stabilized core–shell nanoparticles with hydrophobic, hydrophilic, or superhydrophobic/fluorophilic surface characteristics. This covalent functionalization sequence is extended towards a second noncovalent attachment of tailor‐made nonionic amphiphilic molecules to the pristine coated core–shell nanoparticles via solvophobic (i.e. either hydrophobic, lipophobic, or fluorophobic) interactions. Thereby, orthogonal tuning of the surface energies of nanoparticles via noncovalent interactions is accomplished. As a result, this versatile bilayer coating process enables reversible control over the colloidal stability of the metal oxide nanoparticles in fluorocarbons, hydrocarbons, and water.

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Plasmonic Photothermal Gold Bipyramid Nanoreactors for Ultrafast Real-Time Bioassays

Cited by 94 publications

References 37 publications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Plasmonic Photothermal Nanoparticles for Biomedical Applications

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection

Manufacturing Nanoparticles with Orthogonally Adjustable Dispersibility in Hydrocarbons, Fluorocarbons, and Water

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