Plasmonic nanopore-based platforms for single-molecule Raman scattering

Deng, Liang; Wang, Yixin; Liu, Chen; Hu, Dora Juan Juan; Shum, Perry Ping; Su, Lei

doi:10.1016/j.optcom.2016.04.015

Cited by 8 publications

(4 citation statements)

References 28 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, we observed that |E max /E 0 | values were proportional to the sharpness of the triangle vertices due to the lightning rod effect (which have been explained in the section for figure 3). Similar results have been reported for nanostructures in the shape of pyramids and bowties [54][55][56].…”

Section: E-field Enhancement Analysissupporting

confidence: 89%

Cost-effective large-area Ag nanotube arrays for SERS detections: effects of nanotube geometry

Yang¹,

Chu²

2021

Nanotechnology

View full text Add to dashboard Cite

This study demonstrated highly-ordered metallic nanotube arrays (MeNTAs) with a precisely controlled geometric shape to promote surface-enhanced Raman scattering (SERS). Using both simulation and experimental methods, we designed and fabricated MeNTAs with nanotube geometries that possess a large surface area to absorb probe molecules as well as geometric features capable of inducing hot spots for SERS enhancement. The proposed top-down wafer-scale lithographic and sputter-deposition process is a simple and cost-effective approach to the fabrication of 1 mm×1 mm MeNTA at room temperature. Simulation results of nanotubes with various materials (Au, Ag, and Cu), diameters (100-1500 nm), geometric shapes (circle, equilateral triangle and square) and triangle corner curvatures (ranging from 0 to 300 nm) identified Ag triangles with sharp tips as the geometry best suited to SERS enhancement. The SERS spectra of crystal violet molecules generated from the Ag MeNTAs verified the patterns observed in computational simulations, wherein the effects of MeNTA on SERS decreased with an increase in the size of the nanotubes. Enhancement factor of 1.06×10 9 was obtained from our triangular Ag MeNTA, confirming its efficacy as an ultrahigh sensitivity SERS-active substrate.

show abstract

Section: E-field Enhancement Analysissupporting

confidence: 89%

Cost-effective large-area Ag nanotube arrays for SERS detections: effects of nanotube geometry

Yang¹,

Chu²

2021

Nanotechnology

View full text Add to dashboard Cite

show abstract

“…[8] In the past 10 years, we have witnessed a growing interest in developing different types of plasmonic nanopores for single nanoparticle or molecule detection and sequencing, and more recently to achieve single protein resolution. [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] In most cases, the fabrication of sub-10 nm pores requires complex multi-step processes, including Transmission Electron Microscopy (TEM)assisted sculpturing of the membrane where the plasmonic nanostructures are prepared by using other techniques, such as focus-ion-beam or electron-beam lithography (FIB or EBL, respectively). [29] Intriguing alternative strategies for plasmonic nanopore fabrication have been reported: for instance, optical control of the dielectric breakdown of the membrane has been demonstrated by several groups, [18,[30][31][32] and more recently the use of laser-driven fabrication of nanometric pores received significant interest within the community.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Photochemistry as a Tool to Prepare Metallic Nanopores with Controlled Diameter for Optimized Detection of Single Entities

Lanzavecchia

Kuttruff

Doricchi

et al. 2023

Advanced Optical Materials

View full text Add to dashboard Cite

Plasmonic solid‐state nanopores with tunable hole diameters can be prepared via a photocatalytic effect resulting from the enhanced electromagnetic (EM) field inside a metallic ring on top of a dielectric nanotube. Under white light illumination, the plasmon‐enhanced EM‐field induces a site‐selective metal nucleation and growth within the ring. This approach is used to prepare Au and bimetallic Au–Ag nano‐rings and demonstrate the reduction of the initial inner diameter of the nanopore down to 4 nm. The tunability of the nanopore diameter can be used to enable optimized detection of single entities with different sizes. As a proof‐of‐concept, single object detection of double stranded DNA (dsDNA) and Au nanoparticles (AuNPs) with a diameter down to 15 nm is performed. Numerical simulations provide insights into the EM‐field distribution and confinement, showing that a field intensity enhancement of up to 104 can be achieved inside the nanopores. This localized EM‐field can be used to perform enhanced optical measurements and generate local heating, thereby modifying the properties of the nanopore. Such a flexible approach also represents a valuable tool to investigate plasmon‐driven photochemical reactions, and it can represent an important step toward the realization of new plasmonic devices.

show abstract

“…2,3 As a result of its two strong enhancement mechanisms consisting of electromagnetic (EM) and chemical (charge transfer (CT)) enhancements, 4,5 SERS is an ultrasensitive spectroscopic technique with great potential for use in high-throughput detection and obtaining rich structural information. [6][7][8][9][10][11] SERS is a versatile tool that has been used in numerous fields, [12][13][14][15][16][17][18][19][20][21][22][23][24] including the characterization of compounds and materials, 12,13 single molecule detection, [14][15][16][17][18] immunoassays, [19][20][21] and mechanistic research. [22][23][24] SERS exhibits several advantages: it is non-destructive, rapid, and ultrasensitive and provides detailed molecular fingerprint information.…”

Section: Introductionmentioning

confidence: 99%

The mechanism of an enzymatic reaction-induced SERS transformation for the study of enzyme–molecule interfacial interactions

Chen

Park

et al. 2016

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

We report the observation of a novel effect in which the vibrational frequencies and spectral intensity of enzyme (E)-conjugated surface-enhanced Raman scattering (SERS)-active reporter molecules (4-mercaptobenzoic acid (4-MBA)) shift and change regularly as a function of the concentration of the substrate molecule (S). We attribute the frequency shifts and intensity changes in the E-reporter complex to the binding of S to the active site of E, which affects the electronic structure, polarizability and electron density of the molecule. Our observations demonstrate the creation of an E-conjugated SERS-active reporter complex as a SERS-active nano-mechanical sensor for bio-detection. Specifically, we used glucose oxidase (GOx), which was capable of achieving detection sensitivity comparable to that of a conventional sandwich enzymatic reaction. Furthermore, 2D correlation SERS spectroscopy was performed to better investigate the glucose-responsive mechanism, and the results of these experiments support our proposed conclusion. These findings pave a new pathway for utilizing the specific response to glucose via the SERS method, which can achieve a detection limit of 10 mol L for glucose and cover a much wider concentration range, including the blood glucose concentrations in healthy (3-8 mmol L) and diabetic (9-40 mmol L) individuals, than the current chromogenic assays.

show abstract

Plasmonic nanopore-based platforms for single-molecule Raman scattering

Cited by 8 publications

References 28 publications

Cost-effective large-area Ag nanotube arrays for SERS detections: effects of nanotube geometry

Cost-effective large-area Ag nanotube arrays for SERS detections: effects of nanotube geometry

Plasmonic Photochemistry as a Tool to Prepare Metallic Nanopores with Controlled Diameter for Optimized Detection of Single Entities

The mechanism of an enzymatic reaction-induced SERS transformation for the study of enzyme–molecule interfacial interactions

Contact Info

Product

Resources

About