Plasmonic nanomaterial structuring for SERS enhancement

Purwidyantri, Agnes; Hsu, Chen-Ming; Yang, Chia−Ming; Prabowo, Briliant Adhi; Tian, Ya‐Chung; Lai, Chao‐Sung

doi:10.1039/c8ra10656h

Cited by 22 publications

(18 citation statements)

References 68 publications

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“…The metallic nanostructures confine a strong plasmonic field in the LSPR mode. Next, it interacts with the incident photons to enhance the scattering intensity of the Raman signal [45]. When the immobilized biorecognition elements in the nanostructures capture the target biomarker, the unique Raman fingerprint signal can be obtained.…”

Section: Sers-based Biosensorsmentioning

confidence: 99%

The Challenges of Developing Biosensors for Clinical Assessment: A Review

et al. 2021

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Emerging research in biosensors has attracted much attention worldwide, particularly in response to the recent pandemic outbreak of coronavirus disease 2019 (COVID-19). Nevertheless, initiating research in biosensing applied to the diagnosis of diseases is still challenging for researchers, be it in the preferences of biosensor platforms, selection of biomarkers, detection strategies, or other aspects (e.g., cutoff values) to fulfill the clinical purpose. There are two sides to the development of a diagnostic tool: the biosensor development side and the clinical side. From the development side, the research engineers seek the typical characteristics of a biosensor: sensitivity, selectivity, linearity, stability, and reproducibility. On the other side are the physicians that expect a diagnostic tool that provides fast acquisition of patient information to obtain an early diagnosis or an efficient patient stratification, which consequently allows for making assertive and efficient clinical decisions. The development of diagnostic devices always involves assay developer researchers working as pivots to bridge both sides whose role is to find detection strategies suitable to the clinical needs by understanding (1) the intended use of the technology and its basic principle and (2) the preferable type of test: qualitative or quantitative, sample matrix challenges, biomarker(s) threshold (cutoff value), and if the system requires a mono- or multiplex assay format. This review highlights the challenges for the development of biosensors for clinical assessment and its broad application in multidisciplinary fields. This review paper highlights the following biosensor technologies: magnetoresistive (MR)-based, transistor-based, quartz crystal microbalance (QCM), and optical-based biosensors. Its working mechanisms are discussed with their pros and cons. The article also gives an overview of the most critical parameters that are optimized by developing a diagnostic tool.

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Section: Sers-based Biosensorsmentioning

confidence: 99%

The Challenges of Developing Biosensors for Clinical Assessment: A Review

et al. 2021

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“…The electrode surface nanostructure was templated using 100 nm diameter polystyrene nanobeads following our previously reported studies [26,28,39]. A 5 nm Au film was deposited onto the nanobead-covered ITO surface through a thermal evaporation process using a 2 nm Cr adhesion layer.…”

Section: Bgn and Gna Electrode Fabrication And Surface Characterizationmentioning

confidence: 99%

“…In our previous works, we successfully integrated NSL by drop casting polystyrene nanobeads (with sizes from 500 nm down to 100 nm) onto a solid substrate with a cm 2 scale area in a monolayer hexagonal close-packed arrangement. Followed by the deposition of gold thin films with different techniques, e.g., spin coating and thermal evaporation to various thicknesses, a number of gold nanoarray structures, such as gold nanohoneycombs for electrochemical and FET-based DNA sensors and metal films over nanosphere (MFoN) electrodes for surface-enhanced Raman spectroscopy (SERS) substrates with prominent sensing performance, were generated [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Gold Nanoframe Array Electrode for Straightforward Detection of Hydrogen Peroxide

et al. 2021

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The nanostructuring of a sensing membrane is performed through colloidal nanosphere lithography (NSL) techniques with a tiny polystyrene nanobead template 100 nm in size. The solvent ratio adjustment has been proven to be effective in assisting the monolayer deposition of small templating particles with minimal defects. Two distinct structures, namely, a billowy gold nanostructure (BGN) where the nanobead template is left unetched and a gold nanoframe array (GNA) with a regular ring-like structure after template removal, are used for the extended-gate field-effect transistor (EGFET) electrodes. The GNA structure generates an electroactive surface area significantly (~20%) larger than its geometrical area as well as a greater surface roughness than the BGN. When integrated with the portable constant voltage–constant current (CVCC) FET circuitry for pH screening to determine the optimized measurement conditions for H2O2 sensing, the GNA sensing membrane also shows more improved Nernstian sensitivity at ~50 mV/pH than the BGN electrode. The more optimized sensitivity is then proven using the GNA in the detection of H2O2, the most common representative reactive oxygen species (ROS) involved in the environment, food, and neurodegenerative diseases, such as Parkinson´s and Alzheimer´s diseases. The GNA electrode has a sensitivity of 70.42 mV/log µM [H2O2] and a limit of detection (LoD) of 1.183 µM H2O2. The integrated ion sensing system employing unique, highly ordered gold array gate electrodes and a portable CVCC circuit system has shown a stable real-time output voltage signal, representing an alternative to bulky conventional FET devices for potential on-site H2O2 detection.

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“…In general, plasmons are regarded as collective oscillations of the conduction free electrons taking part in the plasmonic model as well as in Maxwell equations. During the past years, many researchers reported advance techniques and methods for plasmonic properties related with surface plasmon polaritons (SPPs) and localized surface plasmons (LSPs) which offer broad applications in spectroscopy,photonics, energy devices and fluorescence sensing devices [3][4][5][6][7]. All these studies comprise a variety of procedures such as absorption, extinction, Rayleigh and Raman scattering, and electron transfer process.…”

Section: Introductionmentioning

confidence: 99%

ZnO-Nanorod processed PC-SET as the light-harvesting model for plasmontronic fluorescence Sensor

Gupta

Hsu

Purwidyantri

et al. 2020

Sensors and Actuators B: Chemical

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This paper reports the combined plasmon coupled-surface energy transfer (PC-SET) and a distance-dependent model constructed by gold nanoparticles (GNPs) over zinc oxide nanorod (ZnO-NR) as a robust and tunable plasmontronic fluorescence regime for the detection of rhodamine 6G (R6G). Further, the deposition of metal created extraordinary contact through ZnO-NR utilizing a rapid thermal process (RTP) allowing the interaction of plasmon-coupled nature and surface energy transfer from the donor (R6G) to the acceptor (ZnO). The percentage of energy transfer efficiency continuously decreased with the increment of GNPs size, shown by 72.93, 67.52 and 47.86%, corresponding to the increase of the distance between the donor and acceptor of 63.03, 67.25, and 82.49 Å, respectively. In other words, the efficiency of PC-SET complied the 1/d 4 distance dependence model between donor and acceptor molecules with the detection of longdistance ranges from 46.95-120 Å. These findings suggest that PC-SET process has a more realistic agreement with experimental outcomes and highly supports quenching efficiency impacts related to the size of GNPs, in which the smaller size of NPs causes' greater effectiveness towards challenges in light harvest enhanced sensing system.

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Plasmonic nanomaterial structuring for SERS enhancement

Abstract: Au island over nanospheres (AuIoN) structures featuring a three-dimensional (3D) nanostructure on a two-dimensional (2D) array of nanospheres with different adhesion layers were fabricated as surface-enhanced Raman scattering (SERS) substrates.

Cited by 22 publications

References 68 publications

The Challenges of Developing Biosensors for Clinical Assessment: A Review

The Challenges of Developing Biosensors for Clinical Assessment: A Review

Gold Nanoframe Array Electrode for Straightforward Detection of Hydrogen Peroxide

ZnO-Nanorod processed PC-SET as the light-harvesting model for plasmontronic fluorescence Sensor

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