Plasmonic Metasurfaces Based on Pyramidal Nanoholes for High-Efficiency SERS Biosensing

Abstract

An inverted pyramidal metasurface was designed, fabricated, and studied at the nanoscale level for the development of a label-free pathogen detection on a chip platform that merges nanotechnology and surface-enhanced Raman scattering (SERS). Based on the integration and synergy of these ingredients, a virus immunoassay was proposed as a relevant proof of concept for very sensitive detection of hepatitis A virus, for the first time to our best knowledge, in a very small volume (2 μL), without complex signal amplification, allowing to detect a minimal virus concentration of 13 pg/mL. The proposed work aims to develop a high-flux and high-accuracy surface-enhanced Raman spectroscopy (SERS) nanobiosensor for the detection of pathogens to provide an effective method for early and easy water monitoring, which can be fast and convenient.

Surface Lattice Plasmon Resonances by Direct In Situ Substrate Growth of Gold Nanoparticles in Ordered Arrays

“…[3] This compensation generates lattice plasmon resonances, and offers an additional possibility for tuning the optical properties, depending on the angle of illumination and the geometrical parameters of the array. [3] Due to their narrow bandwidth (<2 nm) and long lifetimes, [3][4][5] lattice plasmon resonances already impact the enhancement and manipulation of light-matter interactions, [6][7][8] sensing, [9][10][11][12] displays, [13] information storage [14] and anti-reflective materials. [15] The development of a simple, scalable, and rapid technique that combines the benefits of top-down and bottom-up methods Precise arrangements of plasmonic nanoparticles on substrates are important for designing optoelectronics, sensors and metamaterials with rational electronic, optical and magnetic properties.…”

Ultraviolet/Visible Quasicylindrical Waves on Semimetal Cd3As2 Nanoplates

“…This is beneficial from the assistance of QCW because the constructed interference of incident light and QCW modes results in a higher local field to increase the absorption. These findings pave the way for optimizing the optical performances, such as surface biosensing, [ 37 ] QCW tweezers, [ 38 ] and surface‐enhanced Raman spectroscopy (SERS), [ 39 ] through QCW regulation.…”

Gold Nanoparticles Based Optical Biosensors for Cancer Biomarker Proteins: A Review of the Current Practices

“…When the plasmon frequency, is in resonance with the radiation, the field enhancement is maximum (for spherical particles). The plasmon oscillations must be perpendicular to the surface for scattering to take place; if they are in plane with the surface, no scattering will take place ( Palermo et al, 2021 ; Lu et al, 2020 ). The NP-derived nanostructured metal with SERS may deliver up to 3,000 times more enhancements in the electric field, which is equivalent to an increase in Raman scattering that is 14 orders of magnitude greater in magnitude.…”