Plasmonic metal oxides and their biological applications

Hu, Yihong; Zhang, Baoyue; Haque, Farjana; Ren, Guanghui; Ou, Jian Zhen

doi:10.1039/d2mh00263a

Cited by 14 publications

(2 citation statements)

References 279 publications

(593 reference statements)

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“…Biomarkers have been immobilized by simple amine conjugation and avidin-biotin fixation. In addition, AuNPs also have unique LSPR properties with a high molar extinction coefficient due to their size variations in the presence of the target analyte [ 100 , 101 ]. For example, colloidal suspensions of AuNPs with a diameter of 10 nm take on the color of red wine and produce an LSPR peak at 520 nm in the UV-visible absorption spectra.…”

Section: Application Of 0d Nanomaterials In the Field Of Optical Fibe...mentioning

confidence: 99%

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Singh

Wang

et al. 2022

Biosensors

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This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. The beneficial optical and biological properties of nanomaterials, such as nanoparticle size-dependent signal amplification, plasmon resonance, and charge-transfer capabilities, are widely used in biosensing applications. Due to the biocompatibility and bioreceptor combination, the nanomaterials enhance the sensitivity, limit of detection, specificity, and response time of sensing probes, as well as the signal-to-noise ratio of fiber optic biosensing platforms. This has established a practical method for improving the performance of fiber optic biosensors. With the aforementioned outstanding nanomaterial properties, the development of fiber optic biosensors has been efficiently promoted. This paper reviews the application of numerous novel nanomaterials in the field of optical fiber biosensing and provides a brief explanation of the fiber sensing mechanism.

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Section: Application Of 0d Nanomaterials In the Field Of Optical Fibe...mentioning

confidence: 99%

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Singh

Wang

et al. 2022

Biosensors

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“…In particular, noble metal nanoparticles made from Au and Ag exhibit a phenomenon known as LSPR [13][14][15][16][17][18]. When the conduction electrons on the nanoparticle surface oscillate in resonance with visible or near-infrared light, they create strong electromagnetic fields that are confined or localized at the nanoparticle-dielectric interface [19][20][21][22]. The LSPR wavelength depends on factors such as nanoparticle composition, size, shape, and local dielectric environment [23,24].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Nanoparticle-Enhanced Optical Techniques for Cancer Biomarker Sensing

Fu,

Lin,

Karimi-Maleh

et al. 2023

Biosensors

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This review summarizes recent advances in leveraging localized surface plasmon resonance (LSPR) nanotechnology for sensitive cancer biomarker detection. LSPR arising from noble metal nanoparticles under light excitation enables the enhancement of various optical techniques, including surface-enhanced Raman spectroscopy (SERS), dark-field microscopy (DFM), photothermal imaging, and photoacoustic imaging. Nanoparticle engineering strategies are discussed to optimize LSPR for maximum signal amplification. SERS utilizes electromagnetic enhancement from plasmonic nanostructures to boost inherently weak Raman signals, enabling single-molecule sensitivity for detecting proteins, nucleic acids, and exosomes. DFM visualizes LSPR nanoparticles based on scattered light color, allowing for the ultrasensitive detection of cancer cells, microRNAs, and proteins. Photothermal imaging employs LSPR nanoparticles as contrast agents that convert light to heat, producing thermal images that highlight cancerous tissues. Photoacoustic imaging detects ultrasonic waves generated by LSPR nanoparticle photothermal expansion for deep-tissue imaging. The multiplexing capabilities of LSPR techniques and integration with microfluidics and point-of-care devices are reviewed. Remaining challenges, such as toxicity, standardization, and clinical sample analysis, are examined. Overall, LSPR nanotechnology shows tremendous potential for advancing cancer screening, diagnosis, and treatment monitoring through the integration of nanoparticle engineering, optical techniques, and microscale device platforms.

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Flexible Single Microwire X‐Ray Detector with Ultrahigh Sensitivity for Portable Radiation Detection System

Chen,

Niu,

et al. 2024

Advanced Materials

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Sensitive, flexible, and low false alarm rate X‐ray detector is crucial for medical diagnosis, industrial inspection, and scientific research. However, most semiconductors for X‐ray detectors are susceptible to interference from ambient light, and their high thickness hinders their application in wearable electronics. Herein, a flexible visible‐blind and ultraviolet‐blind X‐ray detector based on Indium‐doped Gallium oxide (Ga2O3:In) single microwire is prepared. Joint experiment−theory characterizations reveal that the Ga2O3:In microwire possess a high crystal quality, large band gap, and satisfactory stability, and reliability. On this basis, an extraordinary sensitivity of 5.9 × 105 µC Gyair−1 cm−2 and a low detection limit of 67.4 nGyair s−1 are achieved based on the prepared Ag/Ga2O3:In/Ag device, which has outstanding operation stability and excellent high temperature stability. Taking advantage of the flexible properties of the single microwire, a portable X‐ray detection system is demonstrated that shows the potential to adapt to flexible and lightweight formats. The proposed X‐ray detection system enables real‐time monitor for X‐rays, which can be displayed on the user interface. More importantly, it has excellent resistance to natural light interference, showing a low false alarm rate. This work provides a feasible method for exploring high‐performance flexible integrated micro/nano X‐ray detection devices.

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Plasmonic metal oxides and their biological applications

Abstract: Metal oxides modified with dopants and defects are an emerging class of novel materials supporting the localized surface plasmon resonance across a wide range of optical wavelengths, which have attracted...

Cited by 14 publications

References 279 publications

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Plasmonic Nanoparticle-Enhanced Optical Techniques for Cancer Biomarker Sensing

Flexible Single Microwire X‐Ray Detector with Ultrahigh Sensitivity for Portable Radiation Detection System

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