Plasmonic liposomes for synergistic photodynamic and photothermal therapy

Oh, Jeongmin; Yoon, Hwan Jun; Park, Ji-Ho

doi:10.1039/c3tb21452d

Cited by 23 publications

(15 citation statements)

References 40 publications

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“…However, current research focuses on co-encapsulating drug and inorganic materials simultaneously in thermosensitive organic carriers to achieve the molecular imaging and photothermal therapy properties of a combinative system (Oh et al, 2014;Gui et al, 2014;Rengan et al, 2014). There are few reports of the pharmaceutical property improvement of combinative DDSs based on their natural merits.…”

Section: Introductionmentioning

confidence: 99%

The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles

Bao

Zhang

Geng

et al. 2014

International Journal of Pharmaceutics

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Section: Introductionmentioning

confidence: 99%

The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles

Bao

Zhang

Geng

et al. 2014

International Journal of Pharmaceutics

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“…This could be attributed to photothermal properties of gold nanoshells coated on the liposomal surface that induced the conversion of absorbed light into heat. 16 It is well known that gold nanomaterials cause conditiondependent fluorescence enhancement and quenching effects previously demonstrated with various fluorophores. 35,36 Therefore, we examined the RB fluorescence intensity before and after releasing gold nanoparticles and RB from the liposomes realized by the addition of Triton X-100 to each sample.…”

Section: Evaluation Of Singlet Oxygen Generation From Gold-liposome Nmentioning

confidence: 98%

Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity

Kautzka¹,

Clement²,

Goldys³

et al. 2017

IJN

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We developed light-triggered liposomes incorporating 3–5 nm hydrophobic gold nanoparticles and Rose Bengal (RB), a well-known photosensitizer used for photodynamic therapy. Singlet oxygen generated by these liposomes with 532 nm light illumination was characterized for varying the molar ratio of lipids and gold nanoparticles while keeping the amount of RB constant. Gold nanoparticles were found to enhance the singlet oxygen generation rate, with a maximum enhancement factor of 1.75 obtained for the molar ratio of hydrogenated soy l -α-phosphatidylcholine:1,2-dioleoyl- sn -glycero-3-phosphoethanolamine- N -(hexanoylamine):gold of 57:5:17 compared with liposomes loaded with RB alone. The experimental results could be explained by the local electric field enhancement caused by gold nanoparticles. We further assessed cellular cytotoxicity of gold-loaded liposomes by encapsulating an antitumor drug, doxorubicin (Dox); such Dox-loaded liposomes were applied to human colorectal cancer cells (HCT116) and exposed to light. Gold-loaded liposomes containing RB and Dox where Dox release was triggered by light were found to exhibit higher cytotoxicity compared with the liposomes loaded with RB and Dox alone. Our results indicate that gold-loaded liposomes incorporating photosensitizers may serve as improved agents in photodynamic therapy and chemotherapy.

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“…However, ROS generation by PS is more or less inhibited due to the excitation energy transfer from PS to PTA in addition to oxygen, and the combination efficiency cannot be maximized as anticipated. In order to overcome this problem, modification of the PS–PTA nanocomplexes has been performed by leaving the space between PS and PTA [7, 26–28]. Very recently Chung et al [7] have prepared the dendrimer porphyrin (DP)-coated gold nanoshell (DP-AuNS) in which dendritic wedges of DP play a role as a spacer between porphyrin and PTA to minimize the additional energy transfer, and they found that the DP-AuNS could be applied to synergistic combination of the PDT and PTT.…”

Section: Introductionmentioning

confidence: 99%

Gold nanorods-conjugated TiO2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells

Lee

Jeong

et al. 2018

J Nanobiotechnol

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BackgroundRecently, a combination of photodynamic therapy (PDT) and photothermal therapy (PTT) to generate reactive oxygen species (ROS) and heat to kill cancer cells, respectively has attracted considerable attention because it gives synergistic effects on the cancer treatment by utilizing the radiation of nontoxic low-energy photons such as long wavelength visible light and near IR (NIR) penetrating into subcutaneous region. For the effective combination of the phototherapies, various organic photosensitizer-conjugated gold nanocomplexes have been developed, but they have still some disadvantages due to photobleaching and unnecessary energy transfer of the organic photosensitizers.ResultsIn this study, we fabricated novel inorganic phototherapeutic nanocomplexes (Au NR–TiO2 NCs) by conjugating gold nanorods (Au NRs) with defective TiO2 nanoparticle clusters (d-TiO2 NP clusters) and characterized their optical and photothermal properties. They were observed to absorb a broad range of visible light and near IR (NIR) from 500 to 1000 nm, exhibiting the generation of ROS as well as the photothermal effect for the simultaneous application of PDT and PTT. The resultant combination of PDT and PTT treatments of HeLa cells incubated with the nanocomplexes caused a synergistic increase in the cell death compared to the single treatment.ConclusionThe higher efficacy of cell death by the combination of PDT and PTT treatments with the nanocomplexes is likely attributed to the increases of ROS generation from the TiO2 NCs with the aid of local surface plasma resonance (LSPR)-induced hot electrons and heat generation from Au NRs, suggesting that Au NR–TiO2 NCs are promising nanomaterials for the in vivo combinatorial phototherapy of cancer.Electronic supplementary materialThe online version of this article (10.1186/s12951-018-0432-4) contains supplementary material, which is available to authorized users.

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Plasmonic liposomes for synergistic photodynamic and photothermal therapy

Cited by 23 publications

References 40 publications

The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles

The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles

Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity

Gold nanorods-conjugated TiO2 nanoclusters for the synergistic combination of phototherapeutic treatments of cancer cells

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