Plasmonic hyperthermia or radiofrequency electric field hyperthermia of cancerous cells through green-synthesized curcumin-coated gold nanoparticles

Rezaeian, Abbas; Amini, Seyed Mohammad; Najafabadi, Mohammad Reza H.; Farsangi, Zohreh Jomeh; Samadian, Hadi

doi:10.1007/s10103-021-03399-7

Cited by 26 publications

(4 citation statements)

References 32 publications

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“…Nevertheless, in vivo experiments in mice are required to verify the effectiveness of the synthesized bioconjugate. It is worth emphasizing that the therapeutic effectiveness of the DOX–PEG–AuNPs–PEG–Tmab conjugate can be significantly increased by external NIR phototherapy or radiofrequency irradiation causing local hyperthermia [ 40 ]. Another option is the use of radioactive AuNPs ( 198 AuNPs), where three various functions: radiotherapy ( 198 Au, β − emitter), chemotherapy (DOX), and guiding vector (Tmab) are combined into one platform.…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

et al. 2023

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Recently, targeted nanoparticles (NPs) have attracted much attention in cancer treatment due to their high potential as carriers for drug delivery. In this article, we present a novel bioconjugate (DOX–AuNPs–Tmab) consisting of gold nanoparticles (AuNPs, 30 nm) attached to chemotherapeutic agent doxorubicin (DOX) and a monoclonal antibody, trastuzumab (Tmab), which exhibited specific binding to HER2 receptors. The size and shape of synthesized AuNPs, as well as their surface modification, were analyzed by the TEM (transmission electron microscopy) and DLS (dynamic light scattering) methods. Biological studies were performed on the SKOV-3 cell line (HER2+) and showed high specificity of binding to the receptors and internalization capabilities, whereas MDA-MB-231 cells (HER2−) did not. Cytotoxicity experiments revealed a decrease in the metabolic activity of cancer cells and surface area reduction of spheroids treated with DOX–AuNPs–Tmab. The bioconjugate induced mainly cell cycle G2/M-phase arrest and late apoptosis. Our results suggest that DOX–AuNPs–Tmab has great potential for targeted therapy of HER2-positive tumors.

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Section: Discussionmentioning

confidence: 99%

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

et al. 2023

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“…Atoms or molecules gather under certain conditions to form stable small clusters (nucleation) and are continuously added to these clusters, which gradually grow into nanoparticles (growth) [79]. There are many types of nanoparticles, including polymer nanoparticles [13] and metal nanomaterials [80].…”

Section: Nanoparticlementioning

confidence: 99%

Advancing Gastrointestinal Health: Curcumin’s Efficacy and Nanopreparations

Ji,

Ma,

Wang

2024

Molecules

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Curcumin (CCM) is a polyphenol compound extracted from the turmeric rhizome. It has various biological activities, including antibacterial, anti-inflammatory, anti-cancer, and antioxidant. Due to its diverse activities, it is often used by researchers to study the therapeutic effects on various diseases. However, its poor solubility leads to poor bioavailability, and it is necessary to increase the water solubility with the help of carriers to improve the therapeutic effect. Gastrointestinal disease is a major global health problem that continues to affect human health. In this review, we have summarized the possible mechanism and therapeutic effect of CCM in various gastrointestinal diseases, and the improvement in the curative effect of CCM with nanopreparation. Finally, we concluded that there have been many clinical trials of CCM in combination with other drugs for the treatment of gastrointestinal disease, but so far, few have used CCM nanomaterials for treatment. Although in vitro and preclinical experiments have shown that nanopreparations can improve the efficacy of CCM, there are still insufficient studies on the safety of carriers.

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“…The use of elements with a high atomic number can enhance the effect of ionising radiation. If these elements could be concentrated within the tumour, they would increase the absorption of ionising radiation compared to the surrounding tissues, thus enhancing the anti‐tumour effect [ 7 ]. Among materials containing elements with a high atomic number, metal nanoparticles have been widely investigated.…”

Section: Introductionmentioning

confidence: 99%

Radiosensitising effect of iron oxide‐gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting

Mohamadkazem

Neshasteh-Riz

Amini

et al. 2023

IET Nanobiotechnology

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Melanoma is a dangerous type of skin cancer sometimes treated with radiotherapy. However, it induces damage to the surrounding healthy tissue and possibly further away areas. Therefore, it is necessary to give a lower dose to the patient with targeted therapy. In this study, the radio‐sensitising effect of gold‐coated iron oxide nanoparticles on electron beam radiotherapy of a melanoma tumour with magnetic targeting in a mouse model was investigated. Gold‐coated iron oxide nanoparticles were prepared in a steady procedure. The melanoma tumour model was induced in mice. Animals were divided into five groups: (1) normal; (2) melanoma; (3) gold‐coated iron oxide nanoparticles alone; (4) electron beam radiotherapy; (5) electron beam radiotherapy plus gold‐coated iron oxide nanoparticles. The magnet was placed on the tumour site for 2 h. The tumours were then exposed to 6 MeV electron beam radiotherapy for a dose of 8 Gy. Inductively coupled plasma optical emission spectrometry test, hematoxylin and eosin staining, and enzyme‐linked immunosorbent assay blood test were also performed. Gold‐coated iron oxide nanoparticles with magnetic targeting before electron beam radiotherapy reduced the growth of the tumour compared to the control group. Blood tests did not show any significant toxicity. Deposition of nanoparticles was more in the tumour and spleen tissue and to a lesser extent in the liver, kidney, and lung tissues. The synergistic effect of nanoparticles administered by the intraperitoneal route and then concentrated into the tumour area by application of an external permanent magnet, before delivery of the electron beam radiotherapy improved the overall cancer treatment outcome and prevented metal distribution side effects.

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Plasmonic hyperthermia or radiofrequency electric field hyperthermia of cancerous cells through green-synthesized curcumin-coated gold nanoparticles

Cited by 26 publications

References 32 publications

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

Doxorubicin- and Trastuzumab-Modified Gold Nanoparticles as Potential Multimodal Agents for Targeted Therapy of HER2+ Cancers

Advancing Gastrointestinal Health: Curcumin’s Efficacy and Nanopreparations

Radiosensitising effect of iron oxide‐gold nanocomplex for electron beam therapy of melanoma in vivo by magnetic targeting

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