Plasmonic Gold Nanostar Mediated Self-Photothermal Modulation of Microfiber Bragg Grating

Hu, Deming; Liu, Tong; Yang, Qiaochu; Xu, Zhiyuan; Long, Junqiu; Ran, Yang; Duan, Xuan‐Ming; Guan, Bai‐Ou

doi:10.1109/jlt.2022.3166226

Cited by 7 publications

(3 citation statements)

References 47 publications

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“…The surface-activated graphene was dried in an oven overnight at 60 ℃ before use. AuNS were prepared as described in previous work using a seed-mediated method 29 . Typically, following the addition of 100 µL of the gold seed (Najing Technology Co., Ltd., China, 0.1nM), 50 µL of 0.1 M ascorbic acid (Shanghai Aladdin Biochemical Technology Co., Ltd., China, 99.0%, AR), and 50 µL of AgNO 3 (Shanghai Macklin Biochemical Co., Ltd., China, 0.1N) were added simultaneously while stirring moderately to a 10 mL solution of 0.25 mM HAuCl 4 (Shanghai Macklin Biochemical Co., Ltd., China, 50% Au basis) containing 10 mL of 1 N HCl (Guangzhou Rongman Biotechnology Co., Ltd., China, 36%, AR).…”

Section: Surface Pretreatment and Synthesis Of The Nanocompositesmentioning

confidence: 99%

“…The hypoxia-responsive uorescent indicators were functionalized on the graphene lm to realize TME sensing. The gold nanostars (AuNS) hybridized in the graphene lm pronouncedly enhanced the intensity of electromagnetic eld, which can surmount the uorescent quenching arising from graphene absorption 29,30 . And the plasmonic effect of AuNS also gave rise to the further improvement of photothermal conversion for PTT 31,32 .…”

Section: Introductionmentioning

confidence: 99%

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Integrating tumor hypoxic sensing and photothermal therapy using a miniaturized fiber-optic theranostic probe

Ran,

Jin,

et al. 2024

Preprint

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Efficient delivery of photons to visceral organs is critical for the treatment of deep-seated tumors taking advantage of photo-theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion with negligible body invasion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, we develop an integrated fiber-optic theranostic (iFOT) probe that merges tumor microenvironment (TME) sensing and photothermal therapy (PTT) by functionalizing the fiber with graphene/gold nanostar hybrid materials and hypoxic-responsive fluorophores. The iFOT probe can quickly detect the hypoxia of xenograft tumors of mice with high sensitivity. The tumors can be photothermally killed on-site through the same fiber probe tightly followed by detection, which presents a high cure rate without the risk of recurrence. More importantly, the iFOT is highly adaptable to the conventional medical imaging and endoscopic techniques, such as laparoscope, magnetic resonance imaging, and ultrasound imaging, which facilitates the imaging-assisted navigation and manipulation by use of the interventional trocar. The proposed integrated fiber-optic theranostic strategy can be used as an effective endoscopic and interventional tool for tackling deep-situated tumor and may open a revolutionized pathway to bridge the separate diagnosis and therapy process in the current stage.

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Section: Surface Pretreatment and Synthesis Of The Nanocompositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrating tumor hypoxic sensing and photothermal therapy using a miniaturized fiber-optic theranostic probe

Ran,

Jin,

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The cladding and leaky mode of the fiber optic excites the strong the photothermal effect of photo-sensitive materials, such as gold nanorods, 102 graphene oxide supported Cu 2-x S nanoplates, 103 and gold nanostar, 104 on the fiber optic surface. As discussed above, a fiber optic with a novel structure is a powerful technique to develop a cytosensor when the suitable recognition elements are modified on the surface of fiber optics.…”

Section: Photosensitive Materials On the Fiber Opticmentioning

confidence: 99%

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

Luo,

Li,

Kong

et al. 2023

Interdisciplinary Medicine

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Precision medicine that takes individual variability into account is a new way to minimize the individual variability for precise diagnosis and to establish the certain strategies of efficient therapy. Due to miniaturization sensing area, remoting detection, and flexible operation of light, fiber optics have been successfully used to develop in vitro, wearable, and implanted biosensors, exhibiting high potential in precision medicine from the diagnosis in vitro to therapy in vivo. When modified with the recognition element, the fiber optic‐based biosensor enables the point of care testing for the detection of disease biomarkers. Meanwhile, the fiber optics packaged in a needle/catheter also monitor the medical Internet of things for the continuous assessment of human health. Moreover, the light from the cladding or leaky mode in the fiber optics excites the strong photothermal effect for therapy. The fiber optic‐based biosensor addressed the drawbacks of plasmonic photothermal therapy that limited penetration depths and non‐selectivity therapy. When integrated with a photothermal agent, the fiber optic‐based biosensors provide in situ information for the diagnosis as well as specifically and efficiently kill the tumor cells in deep tissues. In this review, we summarized the advances of fiber optic‐based biosensors in the diagnosis in vitro and therapy in vivo. The challenges and prospection of the fiber optic‐based biosensor application in precision medicine were also explored in depth.

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A bent fiber optic sensor based on gold nanoparticle-decorated silver film for integration of cytosensor and plasmonic photothermal therapy: A simulation study

Luo

Wen

et al. 2022

Optik

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Plasmonic Gold Nanostar Mediated Self-Photothermal Modulation of Microfiber Bragg Grating

Cited by 7 publications

References 47 publications

Integrating tumor hypoxic sensing and photothermal therapy using a miniaturized fiber-optic theranostic probe

Integrating tumor hypoxic sensing and photothermal therapy using a miniaturized fiber-optic theranostic probe

Advance on fiber optic‐based biosensors for precision medicine: From diagnosis to therapy

A bent fiber optic sensor based on gold nanoparticle-decorated silver film for integration of cytosensor and plasmonic photothermal therapy: A simulation study

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