Plasmonic fluorescence enhancement by metal nanostructures: shaping the future of bionanotechnology

Darvill, Daniel; Centeno, Anthony; Xie, Fang

doi:10.1039/c3cp50415h

Cited by 175 publications

(155 citation statements)

References 115 publications

(123 reference statements)

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“…As the design and synthesis of new photostable NIR/NIR-II fluorophores with high quantum yields has proven extremely challenging, 31 effective and scalable platforms for fluorescence enhancement in the NIR/NIR-II are highly desirable for improving detection sensitivity, and could pave the way for novel high-performance diagnostic devices. 19,32 To date, only a limited number of platforms allowing NIR/NIR-II fluorescence enhancement have been reported. [32][33][34][35][36] Recent work on NIR protein microarrays for detection of disease biomarkers has been based on porous Au films produced by dealloying.…”

Section: Acs Paragon Plus Environmentmentioning

confidence: 99%

“…19 MEF is becoming important in several areas of biomedical research, including DNA 20,21 and RNA 22 sensing, immunoassays, 23,24 and fluorescence-based imaging. 25, 26 The magnitude of fluorescence enhancement in such applications critically depends, among several factors, on the spectral overlap between the LSPR of metal nanoparticle with the spectral properties (i.e.…”

Section: Acs Paragon Plus Environmentmentioning

confidence: 99%

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Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

et al. 2017

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Gold nanostars; self-assembled monolayers; near infrared; NIR-II; metal enhanced fluorescence; localized surface plasmon resonance; fluorescence lifetime.Gold nanostars (AuNS) are receiving increasing attention for their potential applications in bionanotechnology, because of their unique optical properties related to their complex branched morphology. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 confirming that AuNS substrates are promising NIR-MEF platforms for the development of ultrasensitive biosensing applications. Using fluorescence lifetime measurements to semi-quantitatively deconvolute the excitation enhancement from emission enhancement, as well as modelling to simulate the electric field enhancement, we show that a combination of enhanced excitation and an increased radiative decay rate, accompanied by an increase to the quantum yield, contribute to the observed large enhancement. AuNS with different morphological features exhibit significantly different excitation enhancement, indicating the important role of particle morphology on the magnitude of electromagnetic field enhancement, and the resulting enhancement factor. Importantly, enhancement factors of up to 50 times are also achieved in the NIR-II region, suggesting that this system holds promise for the future development of bright probes for NIR/NIR-II biosensing and bioimaging.

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Section: Acs Paragon Plus Environmentmentioning

confidence: 99%

Section: Acs Paragon Plus Environmentmentioning

confidence: 99%

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

et al. 2017

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“…The enhancement factors depend on the type, shape, size, and separation between nanoparticles, and enhancement values from 10 to 10 6 have been reported for some configurations. However, it remains experimentally challenging to produce large-scale nanostructured surfaces with consistent surface coverage density to achieve reproducible MEF properties [17]. Continuous smooth metal films, while simpler to produce, exhibit dramatically lower enhancement factors, typically on the order of 2 [18].…”

Section: Introductionmentioning

confidence: 99%

Effect of surface roughness on metal enhanced fluorescence in planar substrates and optical fibers

Klantsataya¹,

François²,

Ebendorff-Heidepriem³

et al. 2016

Opt. Mater. Express

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Abstract:We investigate the effect of the roughness of thin silver films on the performance of sensors that exploit metal enhanced fluorescence (MEF). Fluorescence enhancement of dye molecules of up to 47 times was observed on planar glass substrates coated with metal films of higher roughness of around 8 nm. We also study the fluorescence enhancement on the rough silver films implemented on a side of an optical fiber and analyze its dependence on the thickness of the metal. A maximum enhancement factor of 15 was demonstrated for thinner coatings where the film could be considered as a layer of particles. The chemical electroless plating technique used here to produce films with desired roughness is a low cost simple alternative to complex procedures that are currently used for fabrication of nanostructured metal coatings on optical fibers for MEF.

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“…A consequence of the interaction is the ability to concentrate light fields with orders of magnitude enhancement at visible and near infrared (NIR) wavelengths to the subwavelength scale. Such enhancements find profound applications in improving the efficiencies of several phenomena such as fluorescence,1, 2, 3 surface‐enhanced Raman spectroscopy (SERS),4, 5, 6, 7, 8 surface‐enhanced infrared absorption,9, 10, 11 single‐molecule detection,12, 13 nonlinear optical effects,14, 15, 16 and multiphoton polymerization 17, 18. Exploiting this highly confined optical field is crucial, but simultaneously it is also challenging to position the desired molecules or particles accurately at these locations.…”

Section: Introductionmentioning

confidence: 99%

Regioselective Localization and Tracking of Biomolecules on Single Gold Nanoparticles

et al. 2015

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Selective localization of biomolecules at the hot spots of a plasmonic nanoparticle is an attractive strategy to exploit the light–matter interaction due to the high field concentration. Current approaches for hot spot targeting are time‐consuming and involve prior knowledge of the hot spots. Multiphoton plasmonic lithography is employed to rapidly immobilize bovine serum albumin (BSA) hydrogel at the hot spot tips of a single gold nanotriangle (AuNT). Regioselectivity and quantity control by manipulating the polarization and intensity of the incident laser are also established. Single AuNTs are tracked using dark‐field scattering spectroscopy and scanning electron microscopy to characterize the regioselective process. Fluorescence lifetime measurements further confirm BSA immobilization on the AuNTs. Here, the AuNT‐BSA hydrogel complexes, in conjunction with single‐particle optical monitoring, can act as a framework for understanding light–molecule interactions at the subnanoparticle level and has potential applications in biophotonics, nanomedicine, and life sciences.

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Plasmonic fluorescence enhancement by metal nanostructures: shaping the future of bionanotechnology

Cited by 175 publications

References 115 publications

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

Gold Nanostar Substrates for Metal-Enhanced Fluorescence through the First and Second Near-Infrared Windows

Effect of surface roughness on metal enhanced fluorescence in planar substrates and optical fibers

Regioselective Localization and Tracking of Biomolecules on Single Gold Nanoparticles

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