Plasmonic enhancement of the antibacterial photodynamic efficiency of a zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles hybrid nanosystem

Abstract

A zinc tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles (ZnTPP/D-g-PAAan/Au NPs) triple hybrid nanosystem has been proposed as a nanodrug for potential photodynamic therapy applications.

Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications

“…The peculiarities of the interaction of ZnTPP molecules with D-g-PNIPAM and Au NPs in hybrid macromolecules have been revealed by the study of the impact of concentrations of photosensitizer, polymer and gold on the optical spectra of the nanohybrids. The relationship of the absorption and FL spectra of ZnTPP in ethanol and water with its concentration was studied in our recent works [ 59 , 60 ]. The dependence of ZnTPP FL intensity of ethanol solution on ZnTPP concentration was found to be non-monotonic, with a maximum FL intensity at ZnTPP concentration 0.005 g/L.…”

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

“…These findings show that AuNR/SiO 2 (15 nm)-OFBV can generate 1 O 2 with high efficiency under two-photon excitation and hence may be used as PSs for TP-PDT therapy of cancer cells due to its wide TPA cross-section. In a study by Yeshchenko et al , 119 a hybrid nanosystem including tetraphenylporphyrin photosensitizer/dextran graft polyacrylamide anionic copolymer/Au nanoparticles (ZnTPP/D- g -PAAan/AuNPs) in a water-based solution was synthesized. In this combination, AuNPs and ZnTTP molecules were installed on the D- g -PAAan copolymer macromolecules as their matrix.…”

Anti-cancer activity of zinc-tetraphenylporphyrin photosensitizer/dextran-graft-polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids

“…The identi-ed characteristics of the anticancer PDT activity of these nanohybrids are in good agreement with their antibacterial PDT activity, as reported in our recent studies. [39][40][41]…”