Plasmonic Enhancement of Molecular Fluorescence

Tam, Felicia; Goodrich, Glenn P.; Johnson, Bruce R.; Halas, Naomi J.

doi:10.1021/nl062901x

Cited by 914 publications

(851 citation statements)

References 58 publications

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“…The characteristics of spontaneous emission can be modified by changing the field of local EM [158]. Plasma metal nanoparticles and photonic crystals are two core structures of nanophotonics; the main effort is to change the spontaneous emission [159]. Although the technique of modifying spontaneous emission was achieved in 40 years, its importance in the transition from photonics to nanophotonics is increasing nowadays.…”

Section: Application Of Weak Couplingmentioning

confidence: 99%

Exciton-plasmon coupling interactions: from principle to applications

et al. 2017

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Abstract:The interaction of exciton-plasmon coupling and the conversion of exciton-plasmon-photon have been widely investigated experimentally and theoretically. In this review, we introduce the exciton-plasmon interaction from basic principle to applications. There are two kinds of exciton-plasmon coupling, which demonstrate different optical properties. The strong exciton-plasmon coupling results in two new mixed states of light and matter separated energetically by a Rabi splitting that exhibits a characteristic anticrossing behavior of the exciton-LSP energy tuning. Compared to strong coupling, such as surface-enhanced Raman scattering, surface plasmon (SP)-enhanced absorption, enhanced fluorescence, or fluorescence quenching, there is no perturbation between wave functions; the interaction here is called the weak coupling. SP resonance (SPR) arises from the collective oscillation induced by the electromagnetic field of light and can be used for investigating the interaction between light and matter beyond the diffraction limit. The study on the interaction between SPR and exaction has drawn wide attention since its discovery not only due to its contribution in deepening and broadening the understanding of SPR but also its contribution to its application in light-emitting diodes, solar cells, low threshold laser, biomedical detection, quantum information processing, and so on.

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Section: Application Of Weak Couplingmentioning

confidence: 99%

Exciton-plasmon coupling interactions: from principle to applications

et al. 2017

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“…zz xx yy (20) Moreover, the orientation of the molecule with respect to the EM field is usually random, so only the average of the nine gradient components enters the transition rate, and we can recast the quadrupolar transition rate into a more compact form: …”

Section: Derivation Of Transition Rates For Multipolar Transitionsmentioning

confidence: 99%

Extraordinary Light-Induced Local Angular Momentum near Metallic Nanoparticles

Alabastri¹,

Yang²,

Manjavacas

et al. 2016

ACS Nano

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The intense local field induced near metallic nanostructures provides strong enhancements for surfaceenhanced spectroscopies, a major focus of plasmonics research over the past decade. Here we consider that plasmonic nanoparticles can also induce remarkably large electromagnetic field gradients near their surfaces. Sizeable field gradients can excite dipole-forbidden transitions in nearby atoms or molecules and provide unique spectroscopic fingerprinting for chemical and bimolecular sensing. Specifically, we investigate how the local field gradients near metallic nanostructures depend on geometry, polarization, and wavelength. We introduce the concept of the local angular momentum (LAM) vector as a useful figure of merit for the design of nanostructures that provide large field gradients. This quantity, based on integrated fields rather than field gradients, is particularly well-suited for optimization using numerical grid-based full wave electromagnetic simulations. The LAM vector has a more compact structure than the gradient matrix and can be straightforwardly associated with the angular momentum of the electromagnetic field incident on the plasmonic structures.

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“…This number of potential binding sites offers a significant source for further enhancing the nanoparticle scattering signal. Finally, in multiparametric applications where both nanoparticles and fluorophores are applied, nanoparticles can be used to enhance fluorescence intensity by up to 50-fold by choosing a nanoparticle with a peak resonant wavelength corresponding to the fluorophore emission (31).…”

Section: Discussionmentioning

confidence: 99%

Plasmonic flow cytometry by immunolabeled nanorods

Crow¹,

Marinakos²,

Cook³

et al. 2010

Cytometry Pt A

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Fluorescence-based flow cytometry measures multiple cellular characteristics, including levels of receptor expression, by assessing the fluorescence intensity from a population of cells whose cell surface receptors are bound by a fluorescently labeled antibody or ligand for that receptor. Functionalized noble metal nanoparticles provide a complementary method of receptor labeling based on plasmonics for population analysis by flow cytometry. The potential benefits of using plasmonic nanoparticles to label cell surface receptors in flow cytometry include scattering intensity from a single particle that is equivalent to fluorescence intensity of 10 5 fluorescein molecules, biocompatibility and low cytotoxicity, and nonquenching optical properties. The large spectral tunability of nanorods also provides convenient access to plasmonic markers with peak surface plasmon resonances ranging from 600 to 2,200 nm, unlike gold nanosphere markers that are limited to visible wavelengths. Gold nanorod-based plasmonic flow cytometry is demonstrated herein by comparing the scattering of cells bound to antiepidermal growth factor receptor (EGFR)-conjugated nanorods to the emission of cells bound to anti-EGFR-conjugated fluorescent labels. EGFR-expressing cells exhibited a statistically significant six-fold increase in scattering when labeled with anti-EGFRconjugated nanorods compared with labeling with IgG1-conjugated nanorods. Large scattering intensities were observed despite using a 1,000-fold lower concentration of nanorod-conjugated antibody relative to the fluorescently labeled antibody. ' 2010International Society for Advancement of Cytometry Key terms flow cytometry; nanorod; plasmonic markers; epidermal growth factor receptor NOBLE metal nanoparticles exhibit unique optical properties that can be exploited for a variety of applications. These properties arise from the interaction of an incident electromagnetic (EM) field with free conduction band electrons in the nanoparticle. The conduction electrons are polarized relative to the heavier positive core ions because of the exciting EM field (1). The charge separation results in a restoring force and subsequent coherent oscillation of the conduction band electrons, sharply enhancing scattering and absorption at specific resonance frequencies. The scattering spectra of nanoparticles are dictated by intrinsic parameters such as their size, shape, and composition, as well as extrinsic factors such as the local refractive index of the surrounding medium. These intrinsic parameters enable the design of gold nanoparticles with peak resonances that can be tuned to specific wavelengths across a relatively wide spectral region (600-2,200 nm) simply by modifying the synthesis protocol to realize the appropriate structural parameters (2,3). Because slight changes in the local refractive index of nanoparticles result in a peak wavelength shift, noble metal nanoparticles are also exquisitely sensitive reporters of their local, nanoscale environment.The unique properties of p...

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Plasmonic Enhancement of Molecular Fluorescence

Cited by 914 publications

References 58 publications

Exciton-plasmon coupling interactions: from principle to applications

Exciton-plasmon coupling interactions: from principle to applications

Extraordinary Light-Induced Local Angular Momentum near Metallic Nanoparticles

Plasmonic flow cytometry by immunolabeled nanorods

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