Plasmon-induced light concentration enhanced imaging visibility as observed by a composite-field microscopy imaging system

Gao, Peng Fei; Gao, Ming; Zou, Hong Yan; Li, Rong Sheng; Zhou, Jun; Ma, Jun; Wang, Qiang; Liu, Feng; Li, Na; Li, Yuan Fang; Huang, Cheng

doi:10.1039/c6sc01055e

Cited by 34 publications

(22 citation statements)

References 41 publications

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“…Gao and coworkers developed a composite‐field microscopy imaging system by coupling the oblique and vertical illumination modes based on the plasmon‐induced light concentration effect. [ 132 ] The oblique and vertical illumination modes were adopted in dark‐ and bright‐field microscopy imaging systems, respectively. In order to achieve a monochromatic background in composite‐field microscopy imaging mode, which adopted both the oblique illumination and the central vertical illumination, the illumination optical path of a dark‐field condenser was modified.…”

Section: Advanced Optical Techniques Utilizing Single Plasmonic Nanopmentioning

confidence: 99%

Individual Plasmonic Nanoprobes for Biosensing and Bioimaging: Recent Advances and Perspectives

Wang

Feng

et al. 2021

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With the advent of nanofabrication techniques, plasmonic nanoparticles (PNPs) have been widely applied in various research fields ranging from photocatalysis to chemical and bio‐sensing. PNPs efficiently convert chemical or physical stimuli in their local environment into optical signals. PNPs also have excellent properties, including good biocompatibility, large surfaces for the attachment of biomolecules, tunable optical properties, strong and stable scattering light, and good conductivity. Thus, single optical biosensors with plasmonic properties enable a broad range of uses of optical imaging techniques in biological sensing and imaging with high spatial and temporal resolution. This work provides a comprehensive overview on the optical properties of single PNPs, the description of five types of commonly used optical imaging techniques, including surface plasmon resonance (SPR) microscopy, surface‐enhanced Raman scattering (SERS) technique, differential interference contrast (DIC) microscopy, total internal reflection scattering (TIRS) microscopy, and dark‐field microscopy (DFM) technique, with an emphasis on their single plasmonic nanoprobes and mechanisms for applications in biological imaging and sensing, as well as the challenges and future trends of these fields.

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Section: Advanced Optical Techniques Utilizing Single Plasmonic Nanopmentioning

confidence: 99%

Individual Plasmonic Nanoprobes for Biosensing and Bioimaging: Recent Advances and Perspectives

Wang

Feng

et al. 2021

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“…MNPs can emit scattered light due to the resonant interaction between the incident light and the collective oscillation of free conduction electrons. This optical phenomenon by LSPR has attracted significant attention for applications in intracellular sensing and imaging [78][79][80]. Traditional LSPR-based analytical methods are generally based on the aggregation of Au nanoparticles, which results in the color change of the solution.…”

Section: Metallic Nanoparticle-based Lspr Sensing Strategies Onto Thementioning

confidence: 99%

Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

et al. 2020

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The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has attracted attention owing to excellent features such as improved sensitivity and selectivity. Moreover, the incorporation of MNPs into biosensing systems may increase the speed and the capability of the biosensors. In this review, we introduce the current progress of the developed cell-based biosensors, cell chip, based on the unique physiochemical features of MNPs. Mainly, we focus on optical intra/extracellular biosensing methods, including fluorescence, localized surface plasmon resonance (LSPR), and surface-enhanced Raman spectroscopy (SERS) based on the coupling of MNPs. We believe that the topics discussed here are useful and able to provide a guideline in the development of new MNP-based cell chip platforms for pharmaceutical applications such as drug screening and toxicological tests in the near future.

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“…Although great attempts to improve the performance of scattering imaging have been made in full swing recently, [ 46–50 ] only a few are suitable for sub‐diffraction‐limited resolution and accurate positioning. Holding the advantages of linear polarization modulation, the accurate localization information of nearby anisotropic nanoparticles can be obtained, [ 51 ] and a more interesting report is the 3D localization available with integrated light sheet super‐resolution microscopy.…”

Section: Introductionmentioning

confidence: 99%

“…Although great attempts to improve the performance of scattering imaging have been made in full swing recently, [46][47][48][49][50] only a few are suitable for sub-diffractionlimited resolution and accurate positioning. Holding the advantages of linear polarization modulation, the accurate localization information of nearby anisotropic nanoparticles can be obtained, [51] and a more interesting report is the 3D localization available with integrated light sheet superresolution microscopy. [52] Compared with some emerging near-field technologies with more demanding requirements, for example, the photoinduced force microscopy [53] and the nanofibre optic force transducers, [54] these methodologies maintain the simplicity and versatility of far-field optical systems.…”

Section: Introductionmentioning

confidence: 99%

Plasmonic locator with sub‐diffraction‐limited resolution for continuously accurate positioning

et al. 2022

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Both the accurate distance measurement and positioning information at the nanoscale are important for the analysis of micro/nano interactions. Plasmon ruler has been an indispensable optical tool to detect the chemical and biological dynamic processes via distance-dependent plasmon coupling in the nearly aggregated state. But it cannot disclose the detailed and accurate information of positions and dynamic movements of its two plasmonic components owing to the inherent diffraction limit. Herein, a plasmonic locator is presented which consists of a heterotypic pair of red/blue plasmonic components with significant wavelength difference (∼150 nm). Attributed to the detuned energy (∼0.64 eV) of the two components, the plasmonic locator has the ability of sub-diffraction-limited resolution (center to center, 30 nm) and accurate positioning under conventional dark-field microscopy, making the relative dynamic information of nearby red/blue components be recorded accurately at video rate. As an important complement to the current aggregate science and technology of plasmonics, this newly developed plasmonic locator presents a facile means to realize super-resolution imaging, accurate positioning, and continuous tracing in chemical and biological interactions at the single-molecule level.

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Plasmon-induced light concentration enhanced imaging visibility as observed by a composite-field microscopy imaging system

Abstract: A composite-field microscopy imaging (iCFM) system is constructed to observe the plasmon-induced light concentration (PILC) effect and to enhance imaging visibility.

Cited by 34 publications

References 41 publications

Individual Plasmonic Nanoprobes for Biosensing and Bioimaging: Recent Advances and Perspectives

Individual Plasmonic Nanoprobes for Biosensing and Bioimaging: Recent Advances and Perspectives

Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

Plasmonic locator with sub‐diffraction‐limited resolution for continuously accurate positioning

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