Plasmodium yoelii: Distinct CD4+CD25+ regulatory T cell responses during the early stages of infection in susceptible and resistant mice

Wu, Yi; Wang, Qinghui; Zheng, Li; Feng, Hui; Liu, Jun; Ma, Shihong; Cao, Yaming

doi:10.1016/j.exppara.2006.09.015

Cited by 60 publications

(60 citation statements)

References 17 publications

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“…Therefore, we postulate that the associations of maternal IL-10 produced by PBMCs, and the A allele of A-1082G, with the increased risk for clinical malaria in young children, were attributable to the increased IL-10 production with the consequent potential suppressive effects on protective immunity to clinical malaria. Consistent with our findings, there is evidence that Treg proliferation might be causally associated with the suppression of T H 1 responses during early malaria infection, thereby increasing parasitemia in BALB/c mice in an IL-10-dependent manner (30).…”

Section: Discussionsupporting

confidence: 78%

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

et al. 2012

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ABSTRACTThe role of interleukin-10 (IL-10) in malaria remains poorly characterized. The aims of this study were to investigate (i) whether genetic variants of the IL-10 gene influence IL-10 production and (ii) whether IL-10 production as well as the genotypes and haplotypes of the IL-10 gene in young children and their mothers are associated with the incidence of clinical malaria in young children. We genotyped three IL-10 single nucleotide polymorphisms in 240 children and their mothers from a longitudinal prospective cohort and assessed the IL-10 production by maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs). Clinical episodes ofPlasmodium falciparummalaria in the children were documented until the second year of life. The polymorphism IL-10 A-1082G (GCC haplotype of three SNPs in IL-10) in children was associated with IL-10 production levels by CBMC cultured withP. falciparum-infected erythrocytes (P= 0.043), with the G allele linked to low IL-10 production capacity. The G allele in children was also significantly associated with a decreased risk for clinical malaria infection in their second year of life (P= 0.016). Furthermore, IL-10 levels measured in maternal PBMCs cultured with infected erythrocytes were associated with increased risk of malaria infection in young children (P< 0.001). In conclusion, IL-10 polymorphisms and IL-10 production capacity were associated with clinical malaria infections in young children. High IL-10 production capacity inherited from parents may diminish immunological protection againstP. falciparuminfection, thereby being a risk for increased malaria morbidity.

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Section: Discussionsupporting

confidence: 78%

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

et al. 2012

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“…The mice of the control group had a mild expression of IL-4 in the spleen, which is higher than that in the mice inoculated with Lm and HKLm. These data showed that live Lm inoculation greatly changed the early cytokine environment of PyLinfected mice and confirmed our previous finding that IFN-γ production at day 3 after PyL infection is essential for the development of protective Th1 response (Wu et al 2007). …”

Section: Live Lm Is Required To Induce a Th1-prone Cytokine Environmesupporting

confidence: 77%

<i>Listeria monocytogenes</i> Inoculation Protects Mice against Blood-Stage <i>Plasmodium yoelii</i> Infection

Han

Zhang

et al. 2013

Tohoku J. Exp. Med.

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Listeria monocytogenes (Lm) has been used as the adjuvant or vector for tumor and viral vaccine for its capability of eliciting all aspects of cell-mediated immunity including T cell activation and interferon-gamma (IFN-γ) production. These effector components play critical roles in the protection against Plasmodium infection in both human malaria and mouse models. Therefore, immune response induced by Lm infection may benefit the defense against malaria. To test this hypothesis, we employed blood-stage Plasmodium yoelii (PyL) infected mice and challenged them with Lm. C57BL/6 and BALB/c mice that are sensitive to PyL infection were used in experiments. These two strains are resistant and sensitive, respectively, to Lm infection. The outcomes of double infection with PyL and Lm and the changes of immune response were investigated. We found that live Lm inoculation inhibited PyL multiplication in both C57BL/6 and BALB/c mice. Lm inoculation increased production of IFN-γ, infiltration of CD11b-positive macrophages and generation of nitric oxide in the spleen of C57BL/6 mice at day 5 after parasite infection. Both CD4-and CD8-positive T cells contributed to IFN-γ production induced by Lm inoculation in PyL-infected mice. The protective effect of Lm against PyL infection depended on the viability of the bacteria. Live Lm, rather than heat-killed Lm, stimulated early IFN-γ production which provided essential cytokine environment for the development of Th1 response in PyL-infected mice. Our data show for the first time that Lm inoculation has protective effect against blood-stage murine malaria, which provides a new clue for enhancing antiPlasmodium immunity.

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“…Recent studies indicated that some pathogens stimulate Tregs as an immune evasion mechanism (9). When it comes to malaria, studies in rodent models (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and humans (21)(22)(23) have demonstrated an increase in Treg frequency shortly upon blood stage infection, although Treg frequency during the course of infection did not correlate with disease severity. Furthermore, attempts to deplete Tregs or to increase Treg frequency in mice prior to infection with a variety of parasite strains (Plasmodium yoelii, P. berghei, or P. chabaudi) have led to conflicting results.…”

mentioning

confidence: 99%

HLA Class II (DR0401) Molecules Induce Foxp3⁺Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

et al. 2014

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c Unlike human malaria parasites that induce persistent infection, some rodent malaria parasites, like Plasmodium yoelii strain 17XNL (Py17XNL), induce a transient (self-curing) malaria infection. Cooperation between CD4 T cells and B cells to produce antibodies is thought to be critical for clearance of Py17XNL parasites from the blood, with major histocompatibility complex (MHC) class II molecules being required for activation of CD4 T cells. In order to better understand the correspondence between murine malaria models and human malaria, and in particular the role of MHC (HLA) class II molecules, we studied the ability of humanized mice expressing human HLA class II molecules to clear Py17XNL infection. We showed that humanized mice expressing HLA-DR4 (DR0401) molecules and lacking mouse MHC class II molecules (EA 0 ) have impaired production of specific antibodies to Py17XNL and cannot cure the infection. In contrast, mice expressing HLA-DR4 (DR0402), HLA-DQ6 (DQ0601), HLA-DQ8 (DQ0302), or HLA-DR3 (DR0301) molecules in an EA 0 background were able to elicit specific antibodies and self-cure the infection. In a series of experiments, we determined that the inability of humanized DR0401.EA 0 mice to elicit specific antibodies was due to expansion and activation of regulatory CD4 ؉

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Plasmodium yoelii: Distinct CD4+CD25+ regulatory T cell responses during the early stages of infection in susceptible and resistant mice

Cited by 60 publications

References 17 publications

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

<i>Listeria monocytogenes</i> Inoculation Protects Mice against Blood-Stage <i>Plasmodium yoelii</i> Infection

HLA Class II (DR0401) Molecules Induce Foxp3⁺Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

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Plasmodium yoelii: Distinct CD4+CD25+ regulatory T cell responses during the early stages of infection in susceptible and resistant mice

Cited by 60 publications

References 17 publications

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

Interleukin-10 (IL-10) Polymorphisms Are Associated with IL-10 Production and Clinical Malaria in Young Children

<i>Listeria monocytogenes</i> Inoculation Protects Mice against Blood-Stage <i>Plasmodium yoelii</i> Infection

HLA Class II (DR0401) Molecules Induce Foxp3+Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria

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HLA Class II (DR0401) Molecules Induce Foxp3⁺Regulatory T Cell Suppression of B Cells in Plasmodium yoelii Strain 17XNL Malaria