Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes

Diniz, Suelen Queiroz; Teixeira-Carvalho, Andréa; Figueiredo, María Marta; Costa, P.A.C.R.; Rocha, Bruno Coelho; Martins‐Filho, Olindo Assis; Goncalves, Ashley; Pereira, Dhélio Batista; Tada, Mauro Shugiro; Oliveira, Fabiano; Gazzinelli, Ricardo T.; Antonelli, Lis Ribeiro do Valle

doi:10.1128/mbio.01247-21

Cited by 6 publications

(2 citation statements)

References 59 publications

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“…Glycolytic monocytes are observed in both infectious settings and inflammatory diseases. Glycolysis fuels the inflammatory program of monocytes in rheumatoid arthritis ( 40 ), in patients with atherosclerotic coronary artery disease ( 41 ), in myocardial infarction ( 42 ), in Chagas disease ( 43 ), and in malaria ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

Radushev,

Karkossa,

Berg

et al. 2024

Front. Immunol.

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IntroductionObesity is associated with a plethora of health complications, including increased susceptibility to infections or decreased vaccine efficacy, partly due to dysregulated immune responses. Monocytes play a crucial role in innate immunity, yet their functional alterations in obesity remain poorly understood.MethodsHere, we employed proteomic and metabolomic analyses to investigate monocyte characteristics in individuals with overweight, obesity, impaired glucose tolerance (IGT), and type 2 diabetes (T2D), compared to lean donors.Results and discussionOur results revealed distinct molecular signatures in monocytes from individuals with obesity, with significant alterations in pathways related to metabolism, cellular migration, and phagocytosis. Moreover, LPS-induced activation of monocytes unveiled heightened metabolic reprogramming towards glycolysis in subjects with obesity accompanied by dysregulated cytokine responses and elevated oxidative stress. Additionally, monocytes from donors with obesity exhibited increased lipid droplet accumulation. These findings shed light on the immunometabolic dysregulation underlying obesity-associated immune dysfunction, highlighting potential targets for therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

Radushev,

Karkossa,

Berg

et al. 2024

Front. Immunol.

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“…Monocytes from malaria patients are reprogrammed to maintain their effector functions increasing their glycolysis rate and decreasing the production of ATP via oxidative phosphorylation. 109 With this shift, mROS is produced as a result of the energy derived from the variation in mitochondrial membrane potential generated by electron transport via the electron transport chain. The close contact of mitochondria with phagolysosomes containing the P. vivax -infected reticulocytes suggests the involvement of mROS with parasite killing.…”

Section: Immunology Of Plasmodium Vivax Malariamentioning

confidence: 99%

Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil

Torres

Ferreira

Castro

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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ABSTRACT. The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority in South America. The Amazonian International Center of Excellence in Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel malaria control and elimination strategies. Based on geographically and epidemiologically distinct sites in the Northeastern Peruvian and Western Brazilian Amazon regions, synergistic projects integrate malaria epidemiology, vector biology, and immunology. The Amazonian ICEMR’s overarching goal is to understand how human behavior and other sociodemographic features of human reservoirs of transmission—predominantly asymptomatically parasitemic people—interact with the major Amazonian malaria vector, Nyssorhynchus (formerly Anopheles) darlingi, and with human immune responses to maintain malaria resilience and continued endemicity in a hypoendemic setting. Here, we will review Amazonian ICEMR’s achievements on the synergies among malaria epidemiology, Plasmodium-vector interactions, and immune response, and how those provide a roadmap for further research, and, most importantly, point toward how to achieve malaria control and elimination in the Americas.

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Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism

Matteucci

Ramalho²,

Hirako³

et al. 2022

Cell Metabolism

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Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes

Abstract: Plasmodium vivax is the most widely distributed causative agent of human malaria. To achieve parasite control, the human immune system develops a substantial inflammatory response that is also responsible for the symptoms of the disease.

Cited by 6 publications

References 59 publications

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

Dysregulated cytokine and oxidative response in hyper-glycolytic monocytes in obesity

Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil

Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism

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