Plasmodium telomeres: a pathogen's perspective

Inhibition of active nuclear transport is an intrinsic trigger of programmed cell death in trypanosomatids

“…Indeed, FISH experiments carried out in Leishmania revealed a significant clustering of telomeric extremities (Figure 1g), as also seen in some other protozoa, such as Plasmodium. 21 As shown in Figure 1f-h, the 2 Â 36 telomeres appeared clustered in about 15 discrete subnuclear compartments at the periphery of the nucleus and close to the NPCs.…”

Coding Fregoli's illusion

“…3). 1,2,5,6 In plasmodia, trypanosomes, and giardias, once a specific cluster has been selected for use from one of its chromosomes, one lucky gene within the lucky cluster is expressed, which means that it is transcribed into mRNA, which is then translated into protein. Neighbors of that gene along the line are silenced.…”

Toward closing rice telomere gaps: mapping and sequence characterization of rice subtelomere regions

“…However, no similarity was found with classified elements. Subtelomeric repeats have been shown to confer a capacity for gene diversification, especially for ''contingency'' (virulence factor) genes, which have very important roles in parasite and in mammalian host genomes (Chiurillo et al 1999(Chiurillo et al , 2000(Chiurillo et al , 2002a(Chiurillo et al , 2002bdel Portillo et al 2001;Scherf et al 2001;Barry et al 2003). The TATRs are interrupted by subsequent insertions of retrotransposons or transposable elements.…”

“…In the human genome, subtelomeres vary in size from 8 kb up to 300 kb Der-Sarkissian et al 2002), whereas in plant genomes, such as tomato (Broun et al 1992;Zhong et al 1998), rice (Ohmido and Fukui 1997;Ohmido et al 2000Ohmido et al , 2001, and tomato (+) potato hybrids , such regions can measure up to 1,000 kb. The highly variable distribution of large duplicated subtelomeric segments are caused by homology-based, non-allelic (ectopic) recombination events between nonhomologous chromosomes Scherf et al 2001;Der-Sarkissian et al 2002). Subtelomeric regions have also been shown to be gene-rich (Bishop et al 2000;Riethman et al 2001;Scherf et al 2001;Bringaud et al 2002;reviewed by Barry et al 2003).…”

“…The highly variable distribution of large duplicated subtelomeric segments are caused by homology-based, non-allelic (ectopic) recombination events between nonhomologous chromosomes Scherf et al 2001;Der-Sarkissian et al 2002). Subtelomeric regions have also been shown to be gene-rich (Bishop et al 2000;Riethman et al 2001;Scherf et al 2001;Bringaud et al 2002;reviewed by Barry et al 2003). Intense efforts to close telomere gaps and integrate telomere repeat stretches (TTAGGG) n into the human genome sequence have been successful using genetic and physical mapping of the human telomere regions (Lese et al 1999; and large telomere-terminal fragments cloned in specialized yeast artificial chromosome (YAC) cloning vehicles called half-YACs.…”