Plasmodium lophurae: The ultrastructure of the exoerythrocytic stages

Beaudoin, R. L.; Strome, C. P. A.

doi:10.1016/0014-4894(73)90091-x

Cited by 16 publications

(11 citation statements)

References 20 publications

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“…2). The most conspicuous structures at this stage are large lipid droplets (0.8-1.2 pm), which have not been found in younger forms (1 6,17). These droplets have the same appearance as the lipid droplets in the cytoplasm of the hepatocyte (Fig.…”

Section: Resultsmentioning

confidence: 66%

“…Groups of merozoites, still kept together by the spongy stroma, were subsequently released in the bloodstream. At 53 h most of the developmental stages leading to the release of merozoites could be found and thereafter parasite numbers decreased while large granulomas became apparent.NFORMATION on the fine structure of tissue stages of ma-I laria parasites was first obtained from avian species (2,3,6, 9,18). Garnham et al (8) reported on the fine structure of exoerythrocytic merozoites of Plasmodium yoelii from the liver of a laboratory-bred mouse 5 1 h post sporozoite inoculation (PI).…”

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confidence: 99%

“…NFORMATION on the fine structure of tissue stages of ma-I laria parasites was first obtained from avian species (2,3,6, 9,18). Garnham et al (8) reported on the fine structure of exoerythrocytic merozoites of Plasmodium yoelii from the liver of a laboratory-bred mouse 5 1 h post sporozoite inoculation (PI).…”

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confidence: 99%

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Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹

Meis¹,

Verhave²,

Jap

et al. 1985

The Journal of Protozoology

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The fine structure of exoerythrocytic merogony of Plasmodium berghei was studied after perfusion-fixation of rat livers from 51 h post-inoculation onwards. Meroblast formation was effected by clefts originating from the parasite plasmalemma and by fusion of vacuoles with each other. Invaginations at the periphery resulted in labyrinthine structures providing the parasites with an enormous increase in surface area, which might facilitate exchange of metabolites. When the parasitophorous vacuole membrane collapsed, the newly formed merozoites were lying free in the hepatocytic cytoplasm, which degenerated until the merozoites were sticking together by a stroma, obviously a remnant of the host hepatocyte. Groups of merozoites, still kept together by the spongy stroma, were subsequently released in the bloodstream. At 53 h most of the developmental stages leading to the release of merozoites could be found and thereafter parasite numbers decreased while large granulomas became apparent.

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Section: Resultsmentioning

confidence: 66%

mentioning

confidence: 99%

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Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹

Meis¹,

Verhave²,

Jap

et al. 1985

The Journal of Protozoology

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“…3A and a). The subpellicular microtubules radiate from the apical polar ring and run down the cytosolic face of the pellicle, ending in the region below the nucleus (approximately two-thirds of the length of the parasite [1,12,13,26,31,120,131]). These spirally arranged microtubules closely follow the serpentine body shape of apicomplexans.…”

Section: Microtubules In the Apicomplexa Organizationmentioning

confidence: 99%

Cytoskeleton of Apicomplexan Parasites

Morrissette

Sibley

2002

Microbiol Mol Biol Rev

410

402

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The Apicomplexa are a phylum of diverse obligate intracellular parasites including Plasmodium spp., the cause of malaria; Toxoplasma gondii and Cryptosporidium parvum, opportunistic pathogens of immunocompromised individuals; and Eimeria spp. and Theileria spp., parasites of considerable agricultural importance. These protozoan parasites share distinctive morphological features, cytoskeletal organization, and modes of replication, motility, and invasion. This review summarizes our current understanding of the cytoskeletal elements, the properties of cytoskeletal proteins, and the role of the cytoskeleton in polarity, motility, invasion, and replication. We discuss the unusual properties of actin and myosin in the Apicomplexa, the highly stereotyped microtubule populations in apicomplexans, and a network of recently discovered novel intermediate filament-like elements in these parasites

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“…The first observations were made on avian Plasmodiidae in tissue cultures Mussachio, 1960, 1965 ;Hepler, Huff and Sprinz, 1966 ;Beaudoin and Strome, 1973) and in avian embryonic liver (Aikawa, Huff and Sprinz, 1968). Observations on tissue stages of the avian parasites Haemoproteus columbae (Haemoproteidae) and Leucocytozoon simondi (Leucocytozoidae) in their natural hosts were reported by Gallucci (1971, 1972) and Desser (1970Desser ( a, 1973 respectively.…”

Section: Résumémentioning

confidence: 99%

Ultrastructural observations on the merocyst and gametocytes of Hepatocystis spp. from Malaysian squirrels

Canning

Sinden

Landau

et al. 1976

Ann. Parasitol. Hum. Comp.

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Summary.An immature merocyst of Hepatocystis malayensis and gametocytes of H. brayi were studied with the electron microscope. The merocyst consisted of a highly complex cyto plasmic reticulum ramifying through an amorphous matrix: the entire complex was enclosed by a simple unit membrane. The host cell was apparently destroyed completely during growth of the cyst.Immature gametocytes were highly amoeboid and showed extensive vacuolisation or attenuation of the cytoplasm. The nucleus contained one or two prominent nucleoli.Mature gametocytes had compact cytoplasm and contained pyriform osmiophilic bodies which were believed to function in the release of the parasites from the host cells. Macrogametocytes were distinguished from microgametocytes by cytoplasmic differences in numbers of ribosomes, and cristate mitochondria and in the extent of development of the smooth endoplasmic reticulum. The compact nuclei of the macrogametocytes had inconspicuous DNA but prominent nucleoli whereas those of the microgametocytes were irregular and showed a central aggregate of DNA. Annales de Parasitologie humaine et comparée (Paris), t. 51, n° 6 39Article available at http://www.parasite-journal.org or https://doi.org/10.1051/parasite/1976516607 ELIZABETH U. CANNING, R. E. SINDEN, IRENE LANDAU AND F. MILTGENIn microgametogenesis karyokinesis of the parent nucleus was delayed until axoneme formation was complete. Then the nuclear buds were extruded into emerging microgametes. At fertilisation the plasmalemmas of the two gametes fused and the single axoneme and nucleus of the microgamete moved into the cytoplasm of the macrogamete. Résumé.Observations sur I'ultrastructure des mérocystes et des gamétocytes d'Hepatocystis spp. des Ecureuils de Malaisie.

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Plasmodium lophurae: The ultrastructure of the exoerythrocytic stages

Cited by 16 publications

References 20 publications

Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹

Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹

Cytoskeleton of Apicomplexan Parasites

Ultrastructural observations on the merocyst and gametocytes of Hepatocystis spp. from Malaysian squirrels

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Plasmodium lophurae: The ultrastructure of the exoerythrocytic stages

Cited by 16 publications

References 20 publications

Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver1

Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver1

Cytoskeleton of Apicomplexan Parasites

Ultrastructural observations on the merocyst and gametocytes of Hepatocystis spp. from Malaysian squirrels

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Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹

Fine Structure of Exoerythrocytic Merozoite Formation of Plasmodium berghei in Rat Liver¹