Plasmodium

Picot, Stéphane; Bienvenu, Anne‐Lise

doi:10.1016/b978-0-12-818731-9.00041-0

Cited by 4 publications

(4 citation statements)

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“…Herbal remedies are usually potential sources of medicine, therefore plants used in those remedies and which possess known activities against fever can be tested for antiplasmodial activities [19]. This may eventually lead to the isolation of lead chemicals for the development of new antimalarial drugs [27] Cleistopholis patens is widely used in ethnomedicine for the treatment of a myriad of health problems like headache, fever, malaria, infection, hyperlipidemia, rheumatoid arthritis, measles and as anti-fertility [7][8][9][10][11]. This explains its choice for investigation against malarial parasites.…”

Section: Resultsmentioning

confidence: 99%

Investigations on the Antimalarial Properties of Cleistopholis patens (Annonaceae) Leaf Methanol Extract and Its Partitioned Fractions in Mice

Famuyiwa

Odediran

Oladiran

2023

IJTDH

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Aim: The methanol extract and partitioned fractions of Cleistopholis patens leaf were evaluated for antiplasmodial activities with a view to establishing its antimalarial potential and identifying the most active partitioned fraction. Methods: The leaf was collected, authenticated, air-dried and powdered. The extract, prepared by maceration in methanol was tested (0-800 mg/kg) against P. berghei berghei in mice using Peter’s four-day test. Normal saline and Chloroquine (10 mg/kg) were negative and positive control respectively. Percentage parasitemia, percentage chemosuppression, effective doses, survival times and percentage survivors were the parameters used for the assessment. The extract was thereafter suspended in water and successively partitioned into n-hexane, dichloromethane and ethyl acetate and the resulting fractions and the aqueous phase were similarly tested at doses 10-80 mg/kg. Results: The methanol extract which was comparable (P=.06) in activity to chloroquine gave 1.05±0.09 percentage parasitemia, 77.45±4.39 percentage chemosuppression at 40 mg/kg and an ED50 and ED90 of 255.83±3.60 and 471.35±15.05 mg/kg. The most active n-hexane fraction elicited a percentage chemosuppression of 82%, 0.87 percentage parasitaemia at 80 mg/kg, moderately high percentage survivor and relatively low ED50 and ED90 of 28.87±5.29 and 56.30±8.44 mg/kg. Conclusion: The methanol extract of C. patens leaf is active against P. berghei berghei and the antimalarial compounds is likely to be concentrated in the n-hexane fraction.

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Section: Resultsmentioning

confidence: 99%

Investigations on the Antimalarial Properties of Cleistopholis patens (Annonaceae) Leaf Methanol Extract and Its Partitioned Fractions in Mice

Famuyiwa

Odediran

Oladiran

2023

IJTDH

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“…The in vivo antimalarial activity of bergenin was also evaluated ( Table 2 ). Experimental models have used animals such as rats and mice infected with P. berghei [ 106 ]. P. berghei is a parasite that infects rodents and was discovered in the 90s in Congo.…”

Section: Biological and Pharmacological Activities Of Bergeninmentioning

confidence: 99%

“…P. berghei is a parasite that infects rodents and was discovered in the 90s in Congo. Since then, it has been widely used for experimental infections, which are considered models for biological and therapeutic studies [ 106 ]. Thirteen mice experimentally infected with P. berghei , with parasitemia of 35%, were treated with 800 mg/kg/day (100 µL twice daily) of bergenin (isolated from the leaves of R. aesculifolia ) for 4 to 6 days intragastrically, and the findings showed that bergenin decreased parasitemia from 35 to 27%.…”

Section: Biological and Pharmacological Activities Of Bergeninmentioning

confidence: 99%

Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

et al. 2023

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Bergenin is a glycosidic derivative of trihydroxybenzoic acid that was discovered in 1880 by Garreau and Machelart from the rhizomes of the medicinal plant Bergenia crassifolia (currently: Saxifraga crassifolia—Saxifragaceae), though was later isolated from several other plant sources. Since its first report, it has aroused interest because it has several pharmacological activities, mainly antioxidant and anti-inflammatory. In addition to this, bergenin has shown potential antimalarial, antileishmanial, trypanocidal, antiviral, antibacterial, antifungal, antinociceptive, antiarthritic, antiulcerogenic, antidiabetic/antiobesity, antiarrhythmic, anticancer, hepatoprotective, neuroprotective and cardioprotective activities. Thus, this review aimed to describe the sources of isolation of bergenin and its in vitro and in vivo biological and pharmacological activities. Bergenin is distributed in many plant species (at least 112 species belonging to 34 families). Both its derivatives (natural and semisynthetic) and extracts with phytochemical proof of its highest concentration are well studied, and none of the studies showed cytotoxicity for healthy cells.

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“…Gametocytes are the cornerstone of parasite transmission from humans to mosquitoes [ 13 ]. The time of their appearance in the peripheral blood after a first erythrocytic cycle is estimated to be 7–15 days for Plasmodium falciparum , and shorter for other Plasmodium species (1–3 days) [ 14 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Protocols for Plasmodium gametocyte production in vitro: an integrative review and analysis

et al. 2022

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Background The production of Plasmodium gametocytes in vitro is a real challenge. Many protocols have been described, but few have resulted in the production of viable and infectious gametocytes in sufficient quantities to conduct research on—but not limited to—transmission-blocking drug and vaccine development. The aim of this review was to identify and discuss gametocyte production protocols that have been developed over the last two decades. Methods We analyzed the original gametocyte production protocols published from 2000 onwards based on a literature search and a thorough review. A systematic review was performed of relevant articles identified in the PubMed, Web of Sciences and ScienceDirect databases. Results A total 23 studies on the production of Plasmodium gametocytes were identified, 19 involving in vitro Plasmodium falciparum, one involving Plasmodium knowlesi and three involving ex vivo Plasmodium vivax. Of the in vitro studies, 90% used environmental stressors to trigger gametocytogenesis. Mature gametocytemia of up to 4% was reported. Conclusions Several biological parameters contribute to an optimal production in vitro of viable and infectious mature gametocytes. The knowledge gained from this systematic review on the molecular mechanisms involved in gametocytogenesis enables reproducible gametocyte protocols with transgenic parasite lines to be set up. This review highlights the need for additional gametocyte production protocols for Plasmodium species other than P. falciparum. Graphical abstract

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Plasmodium

Cited by 4 publications

References 98 publications

Investigations on the Antimalarial Properties of Cleistopholis patens (Annonaceae) Leaf Methanol Extract and Its Partitioned Fractions in Mice

Investigations on the Antimalarial Properties of Cleistopholis patens (Annonaceae) Leaf Methanol Extract and Its Partitioned Fractions in Mice

Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule

Protocols for Plasmodium gametocyte production in vitro: an integrative review and analysis

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