Plasmodium knowlesi: the game changer for malaria eradication

Lee, Wenn-Chyau; Cheong, Fei Wen; Amir, Amirah; Lai, Meng Yee; Tan, Jia Hui; Phang, Wei Kit; Shahari, Shahhaziq; Lau, Yee Ling

doi:10.1186/s12936-022-04131-8

Cited by 25 publications

(25 citation statements)

References 206 publications

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“…Other challenges are summarized in a recent series of reviews [ 398 ]. Meanwhile the impact of P. knowlesi in risk groups in South East Asia remains a significant concern [ 399 ].…”

Section: Current and Future Research Barriers To Effective Treatment ...mentioning

confidence: 99%

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

Walker¹,

Rogerson

2023

Virulence

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Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths each year, concentrated in Africa and in young children, but much of the world’s population remain at risk of infection. In this article, we review the latest developments in the immunogenicity and pathogenesis of malaria, with a particular focus on P. falciparum , the leading malaria killer. Pathogenic factors include parasite-derived toxins and variant surface antigens on infected erythrocytes that mediate sequestration in the deep vasculature. Host response to parasite toxins and to variant antigens is an important determinant of disease severity. Understanding how parasites sequester, and how antibody to variant antigens could prevent sequestration, may lead to new approaches to treat and prevent disease. Difficulties in malaria diagnosis, drug resistance, and specific challenges of treating P. vivax pose challenges to malaria elimination, but vaccines and other preventive strategies may offer improved disease control.

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“…Other challenges are summarized in a recent series of reviews [ 398 ]. Meanwhile the impact of P. knowlesi in risk groups in South East Asia remains a significant concern [ 399 ].…”

Section: Current and Future Research Barriers To Effective Treatment ...mentioning

confidence: 99%

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

Walker¹,

Rogerson

2023

Virulence

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“…Similarly, we do not exclude that Plasmodium knowlesi, which emerged from our analysis as a specific feature of the factor 2-driven patient stratum, may act as a microbial commensal stimulating the allergic response in these patients, despite its classification as a zoonotic malaria parasite [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

et al. 2023

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Background Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It is likely to be primarily activated by food antigens and is classified as a chronic disease for most patients. Therefore, a deeper understanding of the pathogenetic mechanisms underlying EoE is needed to implement and improve therapeutic lines of intervention and ameliorate overall patient wellness. Methods RNA-seq data of 18 different studies on EoE, downloaded from NCBI GEO with faster-qdump (https://github.com/ncbi/sra-tools), were batch-corrected and analyzed for transcriptomics and metatranscriptomics profiling as well as biological process functional enrichment. The EoE TaMMA web app was designed with plotly and dash. Tabula Sapiens raw data were downloaded from the UCSC Cell Browser. Esophageal single-cell raw data analysis was performed within the Automated Single-cell Analysis Pipeline. Single-cell data-driven bulk RNA-seq data deconvolution was performed with MuSiC and CIBERSORTx. Multi-omics integration was performed with MOFA. Results The EoE TaMMA framework pointed out disease-specific molecular signatures, confirming its reliability in reanalyzing transcriptomic data, and providing new EoE-specific molecular markers including CXCL14, distinguishing EoE from gastroesophageal reflux disorder. EoE TaMMA also revealed microbiota dysbiosis as a predominant characteristic of EoE pathogenesis. Finally, the multi-omics analysis highlighted the presence of defined classes of microbial entities in subsets of patients that may participate in inducing the antigen-mediated response typical of EoE pathogenesis. Conclusions Our study showed that the complex EoE molecular network may be unraveled through advanced bioinformatics, integrating different components of the disease process into an omics-based network approach. This may implement EoE management and treatment in the coming years.

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“…Plasmodium knowlesi is an emerging zoonotic parasite transmitted by several anopheline mosquitoes with simio-anthropophilic biting behavior [ 1 ]. The persistent transmission of knowlesi malaria from natural macaque hosts to humans has challenged the malaria elimination efforts in Southeast Asia, particularly in Malaysia [ 2 ]. Controlling knowlesi malaria requires a One Health approach that focuses on the human-animal-environment interface sustaining the disease transmission.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Geographical Variation in Plasmodium knowlesi Apical Membrane Protein 1 (PkAMA-1) on Invasion Dynamics of P. knowlesi

Lee

Lau

et al. 2023

TropicalMed

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Plasmodium knowlesi has emerged as an important zoonotic parasite that causes persistent symptomatic malaria in humans. The signs and symptoms of malaria are attributed to the blood stages of the parasites, which start from the invasion of erythrocytes by the blood stage merozoites. The apical membrane protein 1 (AMA-1) plays an important role in the invasion. In this study, we constructed and expressed recombinant PkAMA-1 domain II (PkAMA-1-DII) representing the predominant haplotypes from Peninsular Malaysia and Malaysian Borneo and raised specific antibodies against the recombinant proteins in rabbits. Despite the minor amino acid sequence variation, antibodies raised against haplotypes from Peninsular Malaysia and Malaysian Borneo demonstrated different invasion inhibition (46.81% and 39.45%, respectively) to P. knowlesi A1-H.1, a reference strain derived from Peninsular Malaysia. Here, we demonstrated how a minor variation in a conserved parasite protein could cast a significant impact on parasite invasion biology, suggesting a complex host-switching of P. knowlesi from different locations. This may challenge the implementation of a standardized One Health approach against the transmission of knowlesi malaria.

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Plasmodium knowlesi: the game changer for malaria eradication

Cited by 25 publications

References 206 publications

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

A multi-omic analysis reveals the esophageal dysbiosis as the predominant trait of eosinophilic esophagitis

The Impact of Geographical Variation in Plasmodium knowlesi Apical Membrane Protein 1 (PkAMA-1) on Invasion Dynamics of P. knowlesi

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