Plasmodium genomics: an approach for learning about and ending human malaria

Garrido-Cárdenas, José Antonio; González-Cerón, Lilia; Manzano‐Agugliaro, Francisco; Mesa-Valle, Concepción

doi:10.1007/s00436-018-6127-9

Cited by 48 publications

(26 citation statements)

References 284 publications

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“…Finally, the seventh orange cluster (1-7) is of small relative importance within this cluster analysis and is focused on malaria. As it is known, malaria is one of the most lethal diseases in the world every year [67]. Malaria causes nearly half a million deaths and was estimated at over 200 million cases, 90 per cent of which occurred in African countries [68].…”

Section: Clustersmentioning

confidence: 99%

Worldwide Research Trends on Medicinal Plants

Alcayde

Garrido-Cárdenas

Manzano‐Agugliaro

2020

IJERPH

Self Cite

216

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The use of medicinal plants has been done since ancient times and may even be considered the origin of modern medicine. Compounds of plant origin have been and still are an important source of compounds for drugs. In this study a bibliometric study of all the works indexed in the Scopus database until 2019 has been carried out, analyzing more than 100,000 publications. On the one hand, the main countries, institutions and authors researching this topic have been identified, as well as their evolution over time. On the other hand, the links between the authors, the countries and the topics under research have been analyzed through the detection of communities. The last two periods, from 2009 to 2014 and from 2015 to 2019, have been examined in terms of research topics. It has been observed that the areas of study or clusters have been reduced, those of the last period being those engaged in unclassified drug, traditional medicine, cancer, in vivo study—antidiabetic activity, and animals—anti-inflammatory activity. In summary, it has been observed that the trend in global research is focused more on the search for new medicines or active compounds rather than on the cultivation or domestication of plant species with this demonstrated potential.

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Section: Clustersmentioning

confidence: 99%

Worldwide Research Trends on Medicinal Plants

Alcayde

Garrido-Cárdenas

Manzano‐Agugliaro

2020

IJERPH

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216

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“…2 a) (White 2017 ). There are six known Plasmodium species that infect humans, such as P. vivax , P. ovale curtisi , P. ovale wallikeri , P. malariae , P. knowlesi, and P. falciparum (Singh et al 2017 ), and among them, P. falciparum is considered the deadliest since it is responsible for driving the most severe forms of the disease (Phillips et al 2017 ; Garrido-Cárdenas et al 2019 ). Malaria is one of the foremost infectious illnesses in the world (generally in low-income countries) affecting around 228 million people per year (World Health Organization 2019 ).…”

Section: Mirnas: Fine Modulators Of Parasitic Infectionsmentioning

confidence: 99%

Human microRNAs in host–parasite interaction: a review

et al. 2020

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MicroRNAs (miRNAs) are a group of small noncoding RNA molecules with significant capacity to regulate the gene expression at the post-transcriptional level in a sequence-specific manner either through translation repression or mRNA degradation triggering a fine-tuning biological impact. They have been implicated in several processes, including cell growth and development, signal transduction, cell proliferation and differentiation, metabolism, apoptosis, inflammation, and immune response modulation. However, over the last few years, extensive studies have shown the relevance of miRNAs in human pathophysiology. Common human parasitic diseases, such as Malaria, Leishmaniasis, Amoebiasis, Chagas disease, Schistosomiasis, Toxoplasmosis, Cryptosporidiosis, Clonorchiasis, and Echinococcosis are the leading cause of death worldwide. Thus, identifying and characterizing parasite-specific miRNAs and their host targets, as well as host-related miRNAs, are important for a deeper understanding of the pathophysiology of parasite-specific diseases at the molecular level. In this review, we have demonstrated the impact of human microRNAs during host−parasite interaction as well as their potential to be used for diagnosis and prognosis purposes.

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“…The homologous genes in different species of malaria parasites are often found in syntenic blocks arranged in different order on the chromosomes (Carlton et al, 2005;Kooij et al, 2005). For more information on Plasmodium genome and genomics associated with parasite development, diseases, diagnosis, epidemiology, and vaccine development please consult (Kirchner et al, 2016;Bourgard et al, 2018;Escalante and Pacheco, 2019;Galinski, 2019;Garrido-Cardenas et al, 2019;Su et al, 2019;Videvall, 2019).…”

Section: Introduction Malaria Parasites Life Cycle and Genomementioning

confidence: 99%

Host-Malaria Parasite Interactions and Impacts on Mutual Evolution

Zhang

Joy

2020

Front. Cell. Infect. Microbiol.

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Malaria is the most deadly parasitic disease, affecting hundreds of millions of people worldwide. Malaria parasites have been associated with their hosts for millions of years. During the long history of host-parasite co-evolution, both parasites and hosts have applied pressure on each other through complex host-parasite molecular interactions. Whereas the hosts activate various immune mechanisms to remove parasites during an infection, the parasites attempt to evade host immunity by diversifying their genome and switching expression of targets of the host immune system. Human intervention to control the disease such as antimalarial drugs and vaccination can greatly alter parasite population dynamics and evolution, particularly the massive applications of antimalarial drugs in recent human history. Vaccination is likely the best method to prevent the disease; however, a partially protective vaccine may have unwanted consequences that require further investigation. Studies of host-parasite interactions and co-evolution will provide important information for designing safe and effective vaccines and for preventing drug resistance. In this essay, we will discuss some interesting molecules involved in host-parasite interactions, including important parasite antigens. We also discuss subjects relevant to drug and vaccine development and some approaches for studying host-parasite interactions.

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Plasmodium genomics: an approach for learning about and ending human malaria

Cited by 48 publications

References 284 publications

Worldwide Research Trends on Medicinal Plants

Worldwide Research Trends on Medicinal Plants

Human microRNAs in host–parasite interaction: a review

Host-Malaria Parasite Interactions and Impacts on Mutual Evolution

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