Plasmodium gallinaceum: Drug-induced ultrastructural changes in oocysts

Terzakis, John A.

doi:10.1016/0014-4894(71)90091-9

Cited by 6 publications

(2 citation statements)

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“…Avian malaria has played a key historical role in the study of human malaria, being a stimulus for the development of medical parasitology (Rivero and Gandon, 2018). It has played a particularly pivotal role in the screening and clinical testing of the first synthetic antimalarials (Coatney et al, 1953;Hewitt, 1940;Rivero and Gandon, 2018) and in the study of their potential use as transmissionblocking compounds (Gerberg, 1971;Ramakrishnan et al, 1963;Terzakis, 1971). Compared with rodent malaria, the avian malaria system has the added advantage of using the parasite's natural vector in the wild, the mosquito Culex pipiens, thereby sidestepping the issues associated with mosquitoparasite combinations without a common evolutionary history (Cohuet et al, 2006;Dong et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

Villa

Buysse

Berthomieu

et al. 2021

International Journal for Parasitology

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Section: Introductionmentioning

confidence: 99%

The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

Villa

Buysse

Berthomieu

et al. 2021

International Journal for Parasitology

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“…Avian malaria has played a key historical role in the study of human malaria, being a stimulus 134 for the development of medical parasitology (Rivero and Gandon, 2018). It has played a particularly 135 pivotal role in the screening and clinical testing of the first synthetic antimalarials (Coatney et al, 136 1953;Hewitt, 1940;Rivero and Gandon, 2018) and in the study of their potential use as transmission-137 blocking compounds (Gerberg, 1971;Ramakrishnan et al, 1963;Terzakis, 1971). Compared with 138 rodent malaria, the avian malaria system has the added advantage of using the parasite's natural vector 139 in the wild, the mosquito Culex pipiens, thereby sidestepping the issues associated with mosquito-140 parasite combinations without a common evolutionary history (Cohuet et al, 2006;Dong et al, 2006).…”

mentioning

confidence: 99%

The transmission-blocking effects antimalarial drugs revisited: mosquito fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

Villa

Buysse

Berthomieu

et al. 2020

Preprint

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on an SP-treated host, we observe both a significant increase in the number of oocysts in the midgut, 43 and a drastic decrease in both sporozoite prevalence (-30%) and burden (-80%) compared to the 44 untreated controls. We discuss the potential mechanisms underlying these seemingly contradictory 45 results and contend that, provided the results are translatable to human malaria, the potential 46 epidemiological and evolutionary consequences of the current preventive use of SP in malaria-endemic 47 countries could be substantial. 48 Keywords: transmission-blocking interventions, vaccines, antimalarial drugs, avian malaria 49 50 throughout the world. Over the last century, these synthetic antimalarials, have replaced traditional 53 herbal remedies such as the (quinine-containing) bark of the South American cinchona trees and the 54 (artemisin-containing) Chinese drug qinghao. Broadly speaking, four major synthetic antimalarial drug 55 classes exist for the treatment of malaria: (i) quinolines (chloroquine, mefloquine), which owe their 56 origins to quinine, interfere with the ability of Plasmodium detoxify hematin, a toxic compound 57 resulting from the degradation of the haemoglobin; (ii) antifolates (pyrimethamine, sulfadoxine, 58 proguanil), so-called because they disturb the folate pathway of Plasmodium, thereby interfering with 59 its DNA and amino-acid synthesis; (iii) atovaquone which interferes with the parasite's mitochondrial 60 electron transport, and (iv) artemisinin derivatives (artemether, artesunate), the most potent and 61 effective anti-malarials to date, which exert their anti-malarial action by perturbing redox homeostasis 62 and the haematin detoxification in the parasite (Müller and Hyde, 2010). 63Although the prime purpose for developing these antimalarials is obviously to prevent or cure 64 the infection of the patients, it has become rapidly obvious that they can also be used to reduce the 65 prevalence of the disease in the population by reducing the onward transmission of the parasite by the 66 vector (Sinden et al., 2012;Wadi et al., 2019). The transmission-blocking effect of antimalarial drugs 67 can take place in three different, albeit non-exclusive, ways. Firstly, drugs may be able to kill, arrest 68 the maturation, alter the sex ratio or reduce the infectivity of gametocytes, the sexual stages of the 69 parasite that are present in the blood and are responsible for the transmission to the mosquito. 70 Secondly, drugs may be able to hinder the development of the parasite within the mosquito. 71Plasmodium development inside the mosquito is complex and involves the fusion of male and female 72 gametocytes to form a zygote, the passage of the mobile zygote through the midgut wall to form an 73 oocyst that grows, undergoing successive mitosis, ruptures and releases thousands of sporozoites that 74 migrate to the salivary glands. Antimalarial drugs, or their metabolites, can find their way to the 75 mosquito midgut where they can block the parasite either directly, by being toxic to any ...

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Dihydrofolate Reductase Inhibitors

Ferone¹

1984

Antimalarial Drug II

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Plasmodium gallinaceum: Drug-induced ultrastructural changes in oocysts

Cited by 6 publications

References 12 publications

The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

The transmission-blocking effects of antimalarial drugs revisited: fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

The transmission-blocking effects antimalarial drugs revisited: mosquito fitness costs and sporontocidal effects of artesunate and sulfadoxine-pyrimethamine

Dihydrofolate Reductase Inhibitors

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