2018
DOI: 10.9734/ijtdh/2018/39642
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Plasmodium falciparum Malaria Clinical and Parasitological Outcomes after In-vivo Artemether-Lumefantrine (AL) Treatment at Bushenyi District Uganda

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Cited by 7 publications
(11 citation statements)
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“…According to the WWARN K13 Genotype-Phenotype Study Group, 10 molecular results need to be compared with either in vivo or in vitro therapeutic efficacy studies (TES). Although in vitro studies were not conducted from samples isolated from this study site, a previous in vivo study 38 from the same study area reported reoccurrence of P. falciparum , 3 days and other subsequent days after treatment with ACTs, thus recommending further molecular surveillance for resistance genes circulating in the area. Moreover, other in vivo studies reported in Uganda showed occurrence of malaria parasites despite the absence of resistant molecular markers.…”
Section: Discussionmentioning
confidence: 88%
“…According to the WWARN K13 Genotype-Phenotype Study Group, 10 molecular results need to be compared with either in vivo or in vitro therapeutic efficacy studies (TES). Although in vitro studies were not conducted from samples isolated from this study site, a previous in vivo study 38 from the same study area reported reoccurrence of P. falciparum , 3 days and other subsequent days after treatment with ACTs, thus recommending further molecular surveillance for resistance genes circulating in the area. Moreover, other in vivo studies reported in Uganda showed occurrence of malaria parasites despite the absence of resistant molecular markers.…”
Section: Discussionmentioning
confidence: 88%
“…Infectious diarrhea remains a major public health concern worldwide (Walker et al, 2012;Liu et al, 2015;GBD, 2016). It kills more than 2,000 children every day, more than AIDS, malaria, and measles (Liu et al, 2015;Chingwaru and Vidmar, 2018;Lemos et al, 2018;Maniga et al, 2018). Multiple pathogens including viruses, bacteria (Blander et al, 2017), fungi (Liguori et al, 2015;Hallen-Adams and Suhr, 2017), and protists (Lanata et al, 2013;Blander et al, 2017) are responsible for diarrhea.…”
Section: Introductionmentioning
confidence: 99%
“…Slides were considered negative if after examination of thick smears, there was no parasite detected in 100 high power fields. For thin smears, they were fixed in methanol solution [7].…”
Section: Laboratory Protocolsmentioning
confidence: 99%
“…However, such studies have not evaluated the possible risk factors influencing the treatment outcomes. This study forms part of a broader study in the same area having used the same study participants who reported poor responses to ACTs [7], despite lacking sufficient resistant molecular markers in circulation [7]. Uganda has not developed a standard health operating protocols to be followed by malaria patients after undergoing treatment.…”
Section: Introductionmentioning
confidence: 99%