Plasmodium berghei: In VivoEfficacy of Albendazole in Different Rodent Models

Dow, G.S.; Reynoldson, J.A.; Thompson, R.C.A.

doi:10.1006/expr.1998.4238

Cited by 13 publications

(9 citation statements)

References 10 publications

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“…Another possibility was that ZS-2A might have acted through metabolic activation of the immune system (Waako et al, 2005) and so parasite clearance could not be total. There is also the fact that not all antimalarials are completely active in P. berghei model (Dow et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

In vivo antiplasmodial activity of ZS-2A: a fraction from chloroform extract of Zizyphus spina-christi root bark against Plasmodium berghei berghei in mice

Adzu¹,

Haruna²,

Salawu³

et al. 2008

International Journal of Biological and Chemical Sciences

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Zizyphus spina-christi is used in ethnomedical practice for the treatment of fever. Bio-assay guided investigation of the plant's root bark was initiated and ZS-2A, a fraction from the chloroform extract of the material, eluted with hexane-ethylacetate (50:50) using flash column chromatography, was evaluated for in vivo antiplasmodial activity against Plasmodium berghei in mice. Four-day suppressive, curative effect against established infection and prophylactic models of antiplasmodial studies were used. The fraction (25, 50 and 100 mg/kg, p.o.) showed a potent activity against the parasite in the suppressive and curative tests. The result suggests that ZS-2A may be a promising agent for malaria treatment.

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Section: Discussionmentioning

confidence: 99%

In vivo antiplasmodial activity of ZS-2A: a fraction from chloroform extract of Zizyphus spina-christi root bark against Plasmodium berghei berghei in mice

Adzu¹,

Haruna²,

Salawu³

et al. 2008

International Journal of Biological and Chemical Sciences

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“…Although the mechanism of antiplasmodial action of this extract has not been elucidated, antiplas- Many published works [17][18][19][20] have investigated biochemical alteration in malaria infection and reported significant alteration (p < 0.05) in biochemical variables. The observed elevations of serum concentration of ALT, AST and ALP in the positive control group of the mice are indications of liver damage in the mice when compared to the animals treated with fractions of the extracts.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In-vivo Antimalarial Activity of Methanol Leaf Extract of <i>Glyphaea brevis</i> in <i>Plasmodium berghei</i>-Infected Mice

Anjuwon¹,

Ibrahim²,

Nok³

2015

Trop. J. Pharm Res

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“…This effect may be due to short duration of action of the extract occasioned by rapid metabolism, and so parasite clearance could not be total. It may also be explained by the fact that not all anti-malarials are completely active against P. berghei model [ 28 ]. The rodent model of malaria that was employed in this study for prediction of efficacy of anti-malarial effect of C. sieberiana root and stem bark extract, was also used for conventional antimalarial agents such as chloroquine, halofantrine, mefloquine and more recently artemisinin derivatives [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial activity of ethanolic extract of root and stem back of Cassia sieberiana DC on mice

Abdulrazak

Asiya

Usman

et al. 2015

J Intercult Ethnopharmacol

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Aim:This study assessed within 4 days of suppressive test in vivo antimalarial activity of Ethanolic extract of root and stem bark of Cassia sieberiana DC against chloroquine sensitive strain of Plasmodium berghei NK65 in mice.Methodology:Two sets, each of five groups of four mice per each group were used. The groups of animals were administered with 100, 200, and 300 mg extract/kg body weight respectively, while positive control group were administered with 5 mg chloroquine/kg body weight and the negative control, were administered with 5 m1 distilled water/kg body weight. Oral acute toxicity was evaluated using up and down procedure.Result:Both the root and stem bark extract of C. sieberiana showed antimalarial property for suppressive tests. Chemo suppression of the root extract exerted significant (P < 0.05) dose-dependent reduction in the level of parasiteamia of 30.7%, 52.7%, and 55.8%. And from stem extract 17.6%, 38.0%, and 63.9% were recorded on mice when compared with 96.0% suppressive rate obtained from weight of chloroquine. The phytochemical screening of the plants root and stem bark extract revealed the presence of alkaloids, anthraquinones, flavonoids, triterpenoids, tannins, cardiac glycosides, saponins, reducing sugars and carbohydrates. The oral median lethal dose was determined to be >3000 mg/kg body weight.Conclusion:The acute toxicity results of this study showed that the plant parts used are assumed to be safe and has anti-plasmodial activity that can be explored for the management of malaria.

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Plasmodium berghei: In VivoEfficacy of Albendazole in Different Rodent Models

Cited by 13 publications

References 10 publications

In vivo antiplasmodial activity of ZS-2A: a fraction from chloroform extract of Zizyphus spina-christi root bark against Plasmodium berghei berghei in mice

In vivo antiplasmodial activity of ZS-2A: a fraction from chloroform extract of Zizyphus spina-christi root bark against Plasmodium berghei berghei in mice

Evaluation of In-vivo Antimalarial Activity of Methanol Leaf Extract of <i>Glyphaea brevis</i> in <i>Plasmodium berghei</i>-Infected Mice

Antiplasmodial activity of ethanolic extract of root and stem back of Cassia sieberiana DC on mice

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