Plasmodium berghei: Antiparasitic effects of orally administered Hypoestoxide in mice

Diterpenes as lead molecules against neglected tropical diseases

“…On the other hand, otostegindiol (25, 50, and 100 mg/kg) against Plasmodium berghei exhibited a significant chemosuppression effect (Endale et al, 2013). It should be mentioned that, till date, a number of promising diterpenes and their derivatives have been isolated from natural sources (Pouvelle et al, 1994;Uys et al, 2002;Riel et al, 2002;Kuria et al, 2002;Köhler et al, 2002;Clarkson et al, 2003;Wei et al, 2004;Loyola et al, 2004;Ospina et al, 2005;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Koka et al, 2009;Lane et al, 2009;Wei et al, 2010;Lin et al, 2010;Wangchuk et al, 2010;Stout et al, 2010;Sebisubi et al, 2010;Stout et al, 2011;Cocquyt et al, 2011;Alasbahi and Melzig, 2012;Ebrahimi et al, 2013;Ehrhardt et al, 2013;Walter et al, 2013;Batista et al, 2013;González et al, 2014;Ma et al, 2014;Avilés et al, 2015;Gbedema et al, 2015;Annan et al, 2015;Sadashiva et al, 2015;Namukobe et al, 2015;Ahmad et al, 2016).…”

“…In some studies, diterpenes in nanoformulations (Roy et al, 2010;Mondal et al, 2013) as well as their laboratory derivatives have been reported to exhibit promising anti-NTDs activities (Watson and Preedy, 2010;Mander and Liu, 2010). Additionally, a number of diterpenes have been reported to act against multiple strains responsible for a particular NTD (Sanchez et al, 2006;Dea-Ayuela et al, 2016;Johnson et al, 1993;Riel et al, 2002;Clarkson et al, 2003;Kalauni et al, 2006;Ojo-Amaize et al, 2007;Wangchuk et al, 2010;González et al, 2014;Namukobe et al, 2015;Liu et al, 1997;Prabu et al, 2015;Encarnación-Dimayuga et al, 2006;Rijo et al, 2010;Arai et al, 2014;Xu et al, 2014a;Xu et al, 2014b) and NTDs (Schmidt et al, 2011;Al Musayeib et al, 2014;Ramírez-Macías et al, 2012;Mothana et al, 2014;Falodun et al, 2014;Mizuno et al, 2015;Mongkolvisut and Sutthivaiyakit, 2007;Rangkaew et al, 2009;Ospina and Rodríguez, 2009;Lekphrom et al, 2010;Almutairi et al, 2014).…”

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

“…Other members of the Acanthaceae family, such as Andrographis paniculata, Hypoestes rosea and Clinacanths siamensis, contain terpenes and xanthones with antiplasmodial activity (Tuntiwachwuttikul et al, 2003;Ojo-Amaize et al, 2007;Mishra et al, 2009). Thus, compounds with antiplasmodial activity found in Acanthaceae might also be present in Adhatoda latibracteata.…”

Hypofolins A – L, ent‐Labdane Diterpenoids from the Roots of Hypoestes phyllostachya ‘Pink Splash’

“…Species of the genus Hypoestes are used in fork medicine for the treatment of high blood pressure, cancer, infection vaginitis, and heart diseases, and as antipyretic and antiphlogistic agents . Phytochemically, plants of the genus Hypoestes are rich sources of diterpenoids, which display a variety of bioactivities including anti‐cancer, anti‐inflammatory, antifungal, antiparasitic, and cytotoxic activities . Especially, hypoestoxide, a novel verticillane diterpenoid isolated from Hypoestes rosea , has attracted much attention from biologists and has been reported to exhibit anti‐inflammatory and anti‐cancer activities …”