Plasmoacanthomas at both angles of mouth treated with carbon dioxide laser ablation

Abstract

REFERENCES1 Elawar A, Dandurand M, Jumez N et al. Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta. Ann Dermatol Venereol 2010; 137: 111-116. 2 Isobe M, Eikawa S, Uenaka A et al. Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient. Cancer Immun 2009; 9: 8-18. 3 Kim SW, Wylie J. Spontaneous regression of pulmonary metastases from breast angiosarcoma. Sarcoma 2008; 2008: 940656. Epub 2008 Dec 3. 4 Papac RJ. Spontaneous regression of cancer: possible mechanisms.

Long‐term remission of unusual plasmoacanthoma on the nasal canthus achieved by intralesional corticosteroid injection: Insights into the pathogenesis and treatment planning based on a literature review

“…Previous studies hypothesized that preceding allergic or chronic inflammation could elicit reactive proliferation of plasma cells via B‐cell growth and differentiation 4,6,8 . Thus, inflammation‐driven deviation to plasma cells can be further enhanced, particularly in intrinsically plasma cell‐rich orifice tissue represented by the lips and gingiva, 9 setting the initial basis for PA. Cheilitis and Candida infection were noted as preceding conditions in previously reported PA cases 2,3 …”

“…Considering the incidence of PA compared with that of plasmacytosis circumorificialis, plasma cell infiltration alone would be less likely to cause hyperkeratotic changes in PA. The literature review elucidated that PA mostly arose in perioral skin or oral mucosa, particularly along the angles of the elderly, suggesting that the accumulation of mechanical or chemical stress may contribute to the pathogenesis of PA 2,3 . Habitual tobacco or gum chewing and use of flavored dentifrices or dentures have been speculated to be associated with local plasma cell proliferation, 4,6 supporting this hypothesis.…”

“…Habitual tobacco or gum chewing and use of flavored dentifrices or dentures have been speculated to be associated with local plasma cell proliferation, 4,6 supporting this hypothesis. Indeed, trauma and insect bite have been implicated in the pathogenesis of PA 2–6 …”

“…PA has been considered as a subtype of plasmacytosis circumorificialis, which was originally described by Zoon as a chronic inflammatory disorder histologically characterized by dense plasma cell infiltration on the glans penis in 1953 1,2 . In addition to that histopathological hallmark of plasmacytosis circumorificialis, PA classically presents psoriasiform hyperkeratosis with resultant warty clinical manifestation 2,3 . Because of such unique clinical presentation, PA needs to be distinguished from various conditions, which potentially exhibit verrucous phenotypes, including verruca vulgaris, lupus vulgaris, deep mycoses, warty tuberculosis, pemphigus vegetans, and squamous cell carcinoma.…”

“…This, along with its rarity, makes the diagnosis of PA quite challenging, particularly when PA is formed at unusual anatomical locations. Because of the limitation in accumulated cases in the literature, a therapeutic approach for PA has not been standardized 2–6 …”