2020
DOI: 10.1101/2020.05.07.081380
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Plasmids shape the diverse accessory resistomes ofEscherichia coliST131

Abstract: 19The human gut microbiome includes beneficial, commensal and pathogenic bacteria that possess 20 antimicrobial resistance (AMR) genes and exchange these predominantly through conjugative 21 plasmids. Escherichia coli is a significant component of the gastrointestinal microbiome and is 22typically non-pathogenic in this niche. In contrast, extra-intestinal pathogenic E. coli (ExPEC) 23including ST131 may occupy other environments like the urinary tract or bloodstream where they 24 express genes enabling AMR an… Show more

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Cited by 2 publications
(7 citation statements)
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“…Hence, these opportunistic pathogens demand more attention than they have been given hitherto as the rich resistome repertoire identified in their genomes makes them reservoirs of ARGs 11,14,21,43 . Moreover, being intestinal denizens and commensals, they can easily share these ARGs with facultative and obligate pathogens of humans and animals 22,4446 .…”
Section: Discussionmentioning
confidence: 99%
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“…Hence, these opportunistic pathogens demand more attention than they have been given hitherto as the rich resistome repertoire identified in their genomes makes them reservoirs of ARGs 11,14,21,43 . Moreover, being intestinal denizens and commensals, they can easily share these ARGs with facultative and obligate pathogens of humans and animals 22,4446 .…”
Section: Discussionmentioning
confidence: 99%
“…Conjugative plasmids have been implicated in the transmission of several resistance determinants within and across species, resulting in the presence of same or very similar resistomes in same and different species and clones 1,4,79 . Thus, the emergence of plasmid-borne resistance genes is always a cause for concern as they help breach the species barrier and shuttle resistance genes (ARGs) from commensals and non-pathogenic bacteria to pathogenic ones or vice versa 3,4,10,11 . Such has been the case with the emergence and rapid spread of extended-spectrum β-lactamases (ESBLs) viz., TEM, SHV, OXA and CTX-M, carbapenemases such as NDM, IMP, VIM, KPC and GES, the mobile colistin resistance gene mcr-1 (to mcr-10 ) and recently, the mobile tigecycline resistance gene, tet ( X ) 1217 Thus, such conjugative plasmids influence the genomic plasticity of several related and unrelated species and genera of bacteria 8,11,1821 .…”
Section: Introductionmentioning
confidence: 99%
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“…Notably, the close evolutionary alignment/distance of plasmids bearing same or different ARGs, but belonging to different incompatibilities in the same isolate (Fig. 7a), depicts the genetic exchanges (recombinations and rearrangements) that occur between plasmids and between plasmids and chromosomes during replication 59,60 . Evidently, the very close sequence and resistome similarity between this study’s plasmids and those obtained from different and same species in other studies worldwide portrays the global dissemination of IncF, IncX, A/C, IncN, and IncI plasmids and their role in ARGs dissemination among bacteria.…”
Section: Discussionmentioning
confidence: 99%