Plasmid-Mediated Resistance to Multiple Antibiotics in Salmonella typhi

Goldstein, F. W.; Chumpitaz, Jorge; Guevara, Jose M.; Papadopoulou, Barbara; Acar, J. F.; Vieu, J.F.

doi:10.1093/infdis/153.2.261

Cited by 80 publications

(43 citation statements)

References 26 publications

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“…Our results confirm earlier findings by Jesudasam and John (1992) and Sudarshan et al (1992) that autotransferring plasmids mediate multidrug resistance in S. typhi, and that such plasmids transfer resistance to all four antibiotics (ACTCo). In the present study no attempt was made to mobilize non-transferable drug resistance, though it is known that the ability to mobilize resistance is also an indication of the presence of plasmid-mediated resistance, albeit non-conjugative.…”

Section: Discussionsupporting

confidence: 93%

Plasmid‐mediated multidrug resistance in Salmonella typhi in Kuwait

Panigrahi

Al-Aneziz

West

1996

Tropical Med Int Health

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SummaryMultidrug resistant Safmonella typhi infection is common in Kuwait. Between January 1993 and December 1994, 266 strains of S. typhi were isolated from blood of suspected typhoid fever cases attending the Infectious Disease Hospital, Kuwait. Of these, 205 strains were isolated from patients from the Indian sub-continent, 1 0 5 (45%) of which showed resistance to one or more drugs; 91 of these resistant strains showed resistance to the oral antimicrobials ampicillin, chloramphenicol, tetracycline and co-trimoxazole ( ACTCo). All 266 isolates were sensitive to fluoroquinolones and cephalosporines. The minimum inhibitory concentrations (MIC) for ampicillin, chloramphenicol and tetracycline in resistant strains were >IOOO @ml. All 9 1 strains with ACTCo resistance pattern transferred their resistance to a recipient E. coli strain, whereas none of the remaining 14 strains with different resistance patterns transferred theirs. This paper reaffirms that multidrug resistant S. typhi is quite common in Kuwait and that such resistance is encoded by auto-transferring plasmids.

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Section: Discussionsupporting

confidence: 93%

Plasmid‐mediated multidrug resistance in Salmonella typhi in Kuwait

Panigrahi

Al-Aneziz

West

1996

Tropical Med Int Health

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“…An extensive epidemic of typhoid fever in Mexico with over 10000 cases was due to multi-drug resistant strains of Salmonella typhi [6]. Similar multiresistant strains of S. typhi have also been reported from other countries [7][8][9]. Vibrio cholerae resistant to commonly used antibiotics have been reported from Philippines [10], Thailand [ 11], Tanzania [12] and Kenya [13].…”

Section: Introductionmentioning

confidence: 87%

The prevalence and genetics of resistance to commonly used antimicrobial agents in faecal Enterobacteriaceae from children in Bangladesh

Mamun

Shears

1993

Epidemiol. Infect.

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SUMMARYThe present study was undertaken to investigate the occurrence of antibiotic resistance in enteric flora in 64 children in rural Bangladesh over a 12-month period. The antibiotic resistance pattern of the isolates varied throughout the year and multiple resistance was highest during the post monsoon period. Seventythree percent of children had isolates resistant to more than three antibiotics throughout the year. Resistance to streptomycin was highest (78%), followed closely by ampicillin (72 %). Of 82 multiply resistant isolates, plasmid DNA was demonstrated in 75%. Plasmid sizes ranged between 3-7 and ItI MDa, the commonest plasmids were of 70, 98 and 110 MDa. Complete or partial resistance was transferred by conjugation from 52 % of the isolates, most frequently by single plasmids. The commonest plasmid incompatibility group was FtI-A (46 %) followed by incompatibility group P (22 %). Plasmids of molecular weight 98 MDa most often hybridized with Ft1

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“…Salmonella typhi resistant to chloramphenicol (C), ampicillin (A) and trimethoprim-sulphamethoxazole (TMP-SMZ) became prevalent in some Asian countries during the late 1980s and early 1990s [1][2][3][4]. It is generally believed that this multidrug resistant (MDR) variety emerged in southern China [2] and then spread to the neighbouring countries.…”

mentioning

confidence: 99%

The concurrent prevalence of chloramphenicol-sensitive and multidrug-resistant Salmonella typhi in Vellore, S. India

John

1996

Epidemiol. Infect.

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SUMMARYA multidrug resistant (MDR) variety of Salmonella typhi emerged as the cause of epidemic typhoid fever in some Asian countries including India, during the late 1980s. We faced the epidemic from April 1990 to the first quarter of 1993. However, during this period we continued to isolate chloramphenicol sensitive (CS) S. typhi also. The relative prevalences showed that the frequency of CS variety was unaffected by the epidemic of MDR variety. This is an unusual epidemiological pattern, which indicates that there may have been factors which favoured the epidemic of the MDR variety but not the CS one.

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Plasmid-Mediated Resistance to Multiple Antibiotics in Salmonella typhi

Cited by 80 publications

References 26 publications

Plasmid‐mediated multidrug resistance in Salmonella typhi in Kuwait

Plasmid‐mediated multidrug resistance in Salmonella typhi in Kuwait

The prevalence and genetics of resistance to commonly used antimicrobial agents in faecal Enterobacteriaceae from children in Bangladesh

The concurrent prevalence of chloramphenicol-sensitive and multidrug-resistant Salmonella typhi in Vellore, S. India

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