Plasmid-chromosome transcriptional crosstalk in multidrug resistant clinical enterobacteria
Laura Toribio-Celestino,
Alicia Calvo-Villamañán,
Cristina Herencias
et al.
Abstract:Conjugative plasmids promote the dissemination and evolution of antimicrobial resistance in bacterial pathogens. However, plasmid acquisition can produce physiological alterations in the bacterial host, leading to potential fitness costs that determine the clinical success of bacteria-plasmid associations. In this study, we used a transcriptomic approach to characterize the interactions between a globally disseminated carbapenem resistance plasmid, pOXA-48, and a diverse collection of multidrug resistant clini… Show more
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