Plasmapheresis for Removal of Myeloperoxidase Antineutrophil Cytoplasmic Antibodies: A Case Report

Yorioka, Noriaki; Taniguchi, Yoshihiko; Amimoto, Dai; Katsutani, Masahira; Kumagai, Junko; Yamakido, Michio

doi:10.1111/j.1744-9987.1998.tb00131.x

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…In addition to larger clinical studies attempting to define the role of classical plasma exchange in RPGN, a number of case series and case reports have been published to delineate the therapeutic effects of extracorporeal plasma purification procedures, including lymphocytapheresis, double membrane filtration, and various forms of immunoadsorption (IA) (8–14).…”

mentioning

confidence: 99%

Three Cases of C‐ANCA‐Positive Vasculitis Treated with Immunoadsorption: Possible Benefit in Early Treatment

Matic¹,

Michelsen

Hofmann

et al. 2001

Therapeutic Apheresis

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Wegener's granulomatosis is a vasculitic disease predominantly affecting the upper respiratory tract, lungs, and kidneys. Three patients with Wegener's granulomatosis and rapidly progressive glomerulonephritis were treated with an intensified regimen of immunoadsorption (IA) (Excorim or Therasorb) in addition to cyclophosphamide (CYC) and methylprednisolone (PRE). Patient A had been in remission under oral CYC/PRE. The first exacerbation was treated successfully with 4 IA treatments without changing medication. Patient B experienced 3 flares within 1 year, which were treated with 28 IA (3–7 IAs/course), intravenous CYC after each course, and PRE. A fall of creatinine levels from 120 to 190 μmol/L to 100 μmol/L was noted after IA and before administration of CYC. Patient C presented in uremia. Autoantibodies were eliminated by 11 IA treatments parallel to CYC/PRE therapy. They remained within a normal range for >1 year's follow‐up; however, kidney function did not return. In conclusion, the observations in Patients A and B suggest a beneficial therapeutic effect of early IA in WG.

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mentioning

confidence: 99%

Three Cases of C‐ANCA‐Positive Vasculitis Treated with Immunoadsorption: Possible Benefit in Early Treatment

Matic¹,

Michelsen

Hofmann

et al. 2001

Therapeutic Apheresis

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“…It is not possible to make recommendations based on this type of evidence, and prospective studies of plasma exchange therapy on patients with well‐defined clinical pictures of renal vasculitis are required to clarify the role of plasma exchange in those situations. For example, in C‐ANCA‐positive renal vasculitis, extracorporeal therapies using either immunoadsorption (58) or plasma exchange (59,61) appear to be effective forms of antibody removal and, perhaps, also bestow clinical benefits (58–61).…”

Section: The Role Of Plasma Exchange In Other Types Of Renal Diseasementioning

confidence: 99%

Apheresis in Cryoglobulinemia Complicating Hepatitis C and in Other Renal Diseases

Dominguez

Sha²

2002

Therapeutic Apheresis

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Removal of cryoglobulins by plasma exchange is now an accepted therapy. Cryoglobulins are circulating complexes that can deposit on small vessels and cause limited or extensive tissue injury. There are 3 major classes of cryoglobulins. Type I cryoglobulins are monoclonal and are detected in a variety of lymphoproliferative disorders. Type II cryoglobulins are mixed containing monoclonal and polyclonal IgG or IgM molecules. Type III cryoglobulins are also mixed and contain polyclonal IgG. Type II cryoglobulins are largely caused by hepatitis C virus infection; hence, they are the most common of the 3 types. In hepatitis C, cryoglobulins are linked to glomerular immune complex injury, oftentimes accompanied by vasculitis of the skin, nerves, and other vital organs. Immediate removal of cryoglobulins by plasma exchange is an effective short‐term treatment that can complement more‐specific therapies. Plasma exchange has also been used to remove other circulating nephrotoxic agents such as antiglomerular basement antibodies that cause Goodpasture's syndrome, protease inhibitor autoantibodies that cause thrombotic thrombocytopenic purpura, and antiglomerular factors that cause some types of focal glomerulosclerosis.

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Apheresis to treat systemic vasculitis

2018

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Plasmapheresis for Removal of Myeloperoxidase Antineutrophil Cytoplasmic Antibodies: A Case Report

Cited by 7 publications

References 7 publications

Three Cases of C‐ANCA‐Positive Vasculitis Treated with Immunoadsorption: Possible Benefit in Early Treatment

Three Cases of C‐ANCA‐Positive Vasculitis Treated with Immunoadsorption: Possible Benefit in Early Treatment

Apheresis in Cryoglobulinemia Complicating Hepatitis C and in Other Renal Diseases

Apheresis to treat systemic vasculitis

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