Plasmapheresis Combined With Somatostatin Is the Successful Treatment of Porphyrias

Medenica, Rajko; Huschart, Teresa; Mukerjee, Sonjoy; Lazovic, G; Long, Paul; Corbitt, Wendy

doi:10.1097/00007611-199510001-00084

Southern Medical Journal

1995

DOI: 10.1097/00007611-199510001-00084

|View full text |Cite

Plasmapheresis Combined With Somatostatin Is the Successful Treatment of Porphyrias

Rajko Medenica¹,

Teresa Huschart²,

Sonjoy Mukerjee³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1997

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Plasmapheresis Combined with Somatostatin is a Successful Treatment of Porphyrias

Medenica¹,

Lazovic²,

Long³

et al. 1997

Therapeutic Apheresis

View full text Add to dashboard Cite

During acute attacks of hepatic porphyria, levels of polypeptides, vasoactive intestinal peptides, neurotensin, substance P, pancreatic polypeptide, gastrin releasing polypeptide, gastrin, and motilin increased in the circulation while the clinical symptoms were evident. However, somatostatin decrease was not detected. Somatostatin belongs to a group of regulatory peptides that antagonize the action of endogenous steroid hormones, and decreasing their bioavailability decreases the rate of synthesis of delta-aminolevulinate synthase, alpha-aminolevunilic acid (ALA), and polypeptides. Plasma exchange was conducted in courses for 2 consecutive days every 28 days (total of 6 courses), removing more than 100% of the patient plasma each time. Between the 2 courses of plasmapheresis, subcutaneous injections of somatostatin (100-500 mcg) were administered. A lasting disappearance of pain and complete remission were obtained in all 7 patients treated. Plasmapheresis combined with somatostatin may be considered as a treatment of porphyria exacerbation.

show abstract

Plasmapheresis Combined with Somatostatin is a Successful Treatment of Porphyrias

Medenica¹,

Lazovic²,

Long³

et al. 1997

Therapeutic Apheresis

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Plasmapheresis Combined With Somatostatin Is the Successful Treatment of Porphyrias

Cited by 1 publication

References 0 publications

Plasmapheresis Combined with Somatostatin is a Successful Treatment of Porphyrias

Plasmapheresis Combined with Somatostatin is a Successful Treatment of Porphyrias

Contact Info

Product

Resources

About