Plasmapheresis: An adjunct to medical management of severe hyperthyroidism

Braithwaite, Susan S.; Brooks, Marion H.; Collins, Sharon L.; Bermes, Edward W.

doi:10.1002/jca.2920030208

Cited by 22 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in patients with iatrogenic thyrotoxicosis or for whom antithyroid drugs are contraindicated or who are resistant to antithyroid drugs, further therapies are needed to restore euthyroid hormone status. The reported cases suggested that therapeutic plasma exchange (TPE) has been used as an additional treatment or preparation for surgery [5][6][7].…”

Section: Introductionmentioning

confidence: 98%

Preoperative therapeutic plasma exchange in patients with thyrotoxicosis

Ezer

Çalışkan

Parlakgümüş

et al. 2009

J of Clinical Apheresis

View full text Add to dashboard Cite

The purpose of this report was to determine the effectiveness of therapeutic plasma exchange (TPE) in preoperative preparation of patients with thyrotoxicosis scheduled for either thyroid or nonthyroid surgery. We retrospectively reviewed 11 patients with thyrotoxicosis and those who prepared surgery with plasmapheresis between 1999 and 2008 at our institution. Ten patients underwent thyroid surgery and one patient was operated for femur fracture during antithyroid drug treatment. The indications for plasmapheresis in all patients with severe thyrotoxicosis were poor response to medical treatment (seven patients), agronulocytosis due to antithyroid drugs (three patients), iodine-induced thyrotoxicosis (Jodd Basedow effect in one patient), and rapid preparation for urgent orthopedic operation (one patient). After TPE, we observed a marked decrease in free thyroxin (FT3) and free triiodothyronin (FT4) levels; however, the decline in the biochemical values were not statically significant (P > 0.62, P > 0.15). Although both FT3 and FT4 levels remained above the normal limits in two of 11 patients, the signs and symptoms of thyrotoxicosis improved in all patients and no thyroid storm observed during the perioperative period. TPE can be considered a safe and effective alternative to prepare patients with thyrotoxicosis for surgery when drug treatment fails or is contraindicated and when emergency surgery is required.

show abstract

Section: Introductionmentioning

confidence: 98%

Preoperative therapeutic plasma exchange in patients with thyrotoxicosis

Ezer

Çalışkan

Parlakgümüş

et al. 2009

J of Clinical Apheresis

View full text Add to dashboard Cite

show abstract

“…In our case, for example, the best response to TPE was in a patient with a non-autoimmune disease. The success of TPE in this case was attributed to the dilution of hormones and the generation of free proteins with new binding sites, which reduced their free fractions and thus their biological activity [15][16][17][18][19][20][21]. While this is effective in the short-term, its effect is transient and so TPE cannot be used as definitive therapy.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Plasmapheresis in Patients with Thyrotoxicosis. Report of Two Cases

Guillermo¹,

R²,

Arango³

2015

Rheumatology (Sunnyvale)

View full text Add to dashboard Cite

show abstract

“…Plasmapheresis is a medical procedure that removes the thyroid hormones and antibodies from the bloodstream of patients who are in need of urgent surgical intervention. It has been utilized for the treatment of several immunologic and nonimmunologic disorders such as Graves' disease, intoxication of levothyroxin and amiodarone (4,5). Here, we report the case of a patient with toxic multinodular goiter (TMNG) who was prepared for surgery by plasmapheresis due to the side effects of antithyroid drugs.…”

Section: Introductionmentioning

confidence: 94%