Plasmapheresis

Antibody Reactivity of a Standardized Human Serum Protein Solution Against a Spectrum of Microbial Pathogens and Toxins: Comparison with Fresh Frozen Plasma

“…TPE is successfully used in the treatment of intoxications and a variety of autoimmune and congenital diseases. The underlying concept of TPE is the elimination of pathogenic substances including toxins, circulating immune complexes, and antibodies which can cause autoaggressive tissue damage (3,4). This procedure is meanwhile widely accepted and is used routinely in clinical practice (5,6).…”

“…Therapeutic plasma exchange (TPE) is a standard method for the treatment of certain congenital syndromes and a variety of autoaggressive diseases. Of these, systemic lupus erythematosus (1,2), Goodpasture's syndrome (3), Guillain‐Barré syndrome (GBS) (4), and glomerulonephritis can be improved by removal of pathological antibodies (5) or circulating immune complexes (6). Moreover, patients suffering from poisoning with toxins, irrespective of their nature, can also be treated by TPE, e.g., phalloidin, a toxin resulting from the ingestion of Amanita phalloides , can be eliminated from such highly endangered patients (3).…”