Plasmacytoma of the mandible associated with a dental implant failure: a clinical report

Poggio, Carlo E.

doi:10.1111/j.1600-0501.2007.01361.x

Cited by 47 publications

(50 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,8,9 Solitary plasmacytoma of the mandible also has various radiographic findings: "punched-out" appearance, ill-defined destructive radiolucencies and appearance of a multiloculated lesion. 4,[10][11][12][13][14] In the present case, no additional osteolytic lesions were caused by multiple myeloma; however the left posterior mandible and ramal area were associated with plasmacytoma demonstrating illdefined destructive radiolucencies. Early myeloma may not reveal observable changes on plain radiographs.…”

Section: Discussionmentioning

confidence: 99%

Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy

Ch²,

Ks³

et al. 2013

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

A 65-year-old female visited our hospital complaining of a swelling on the left cheek area of 2 years' duration. A panoramic radiograph revealed an ill-defined osteolytic radiolucent bony lesion involving the left mandibular angle, ascending ramus, coronoid process and condylar process. Histological examination showed the mandibular lesion to be a plasmacytoma, and a systemic work-up was obtained to rule out multiple myeloma. Contrast-enhanced CT images showed a well-defined and slightly enhanced round mass on the left ramal area, accompanied by the destruction of the left ramus and posterior maxilla. An 18 F-fluorodeoxyglucose positron emission tomography CT ( 18 F-FDG PET/CT) scan revealed a hypermetabolic mass extending from the left mandible to the left maxillary sinus. The patient had M-protein in serum and urine, plasma cells up to 36.5% on bone marrow biopsy and anaemia as a clinical complication. The patient was diagnosed with multiple myeloma and received chemotherapy with thalidomide, cyclophosphamide and dexamethasone. A PET/CT scan taken 6 months later revealed that the hypermetabolic mass had disappeared and there was remarkable bone formation on the left mandible compared with a previous PET/CT scan. A panoramic radiograph taken 8 months later also demonstrated a prominent bone formation of the affected site. To the best of our knowledge, the current case is the first report of multiple myeloma presenting as plasmacytoma of the mandible with an FDG PET/CT scan. The lesion was solitary at diagnosis, and remarkable bone formation was newly observed on the radiographic examination during chemotherapy. Dentomaxillofacial Radiology ( Keywords: multiple myeloma; plasmacytoma; positron-emission tomography; jaw; bone formation Case reportA 65-year-old female visited our hospital complaining of a swelling on the left cheek area for 2 years. The extraoral examination revealed an asymptomatic expansion on the left cheek area. Intraorally, the involved area showed a soft to fluctuant consistency and was covered by locally ulcerated mucosa. There was no complaint of paraesthesia or anaesthesia. A panoramic radiograph was acquired using an Orthopantomograph ® OP 100D (Instrumentarium Imaging, Tuusula, Finland) and revealed an ill-defined osteolytic radiolucent bony lesion involving the left mandibular angle, ascending ramus, coronoid process and condylar process (Figure 1). It also demonstrated a loss of the inferior border of the left zygomatic process of the maxilla and a soft-tissue shadow around the affected area. The lesion contained septum-like residual bone at the angle of the mandible. An incisional biopsy of the left anterior ramal area was performed under local anaesthesia, during which intra-oral bleeding was not noted. A histopathological examination of the specimen

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy

Ch²,

Ks³

et al. 2013

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

show abstract

“…However, a direct cause-effect relation between the metal and sarcomatous degeneration in patients has not been demonstrated to date (Black, 1988b;Brown et al, 1987;Case et al, 1996;Goodfellow, 1992). As regards titanium specifically, there are reports of neoplasia in association with dental implants, such as squamous cell carcinoma (Gallego et al, 2008) osteosarcoma (McGuff et al, 2008 and plasmacytoma of the mandible (Poggio, 2007). It is of note that TiO 2 was classified by the International Agency for Cancer Research, as possibly carcinogenic to humans (Group 2B) (Baan et al, 2006).…”

Section: Clinical Implications Of Corrosionmentioning

confidence: 99%

Systemic and Local Tissue Response to Titanium Corrosion

Olmedo¹,

Tasat²,

Duffó³

et al. 2012

Pitting Corrosion

View full text Add to dashboard Cite

“…These metal ions and wear debris may also contribute to aseptic loosening by promoting inflammatory complications that may result in macrophage activation, bone resorption, and, rarely, in the potential development of neoplasia (Poggio, 2007;McGuff et al, 2008). Recently, titanium dioxide (TiO 2 ) was classified as possibly carcinogenic to human beings (i.e., group 2B) at the International Agency for Research on Cancer (IARC) (Baan et al, 2006).…”

Section: Clinical Relevance Of Corrosionmentioning

confidence: 99%

Electrical Implications of Corrosion for Osseointegration of Titanium Implants

et al. 2011

View full text Add to dashboard Cite

The success rate of titanium implants for dental and orthopedic applications depends on the ability of surrounding bone tissue to integrate with the surface of the device, and it remains far from ideal in patients with bone compromised by physiological factors. The electrical properties and electrical stimulation of bone have been shown to control its growth and healing and can enhance osseointegration. Bone cells are also sensitive to the chemical products generated during corrosion events, but less is known about how the electrical signals associated with corrosion might affect osseointegration. The metallic nature of the materials used for implant applications and the corrosive environments found in the human body, in combination with the continuous and cyclic loads to which these implants are exposed, may lead to corrosion and its corresponding electrochemical products. The abnormal electrical currents produced during corrosion can convert any metallic implant into an electrode, and the negative impact on the surrounding tissue due to these extreme signals could be an additional cause of poor performance and rejection of implants. Here, we review basic aspects of the electrical properties and electrical stimulation of bone, as well as fundamental concepts of aqueous corrosion and its electrical and clinical implications.

show abstract

Plasmacytoma of the mandible associated with a dental implant failure: a clinical report

Cited by 47 publications

References 7 publications

Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy

Multiple myeloma presenting as plasmacytoma of the jaws showing prominent bone formation during chemotherapy

Systemic and Local Tissue Response to Titanium Corrosion

Electrical Implications of Corrosion for Osseointegration of Titanium Implants

Contact Info

Product

Resources

About