Plasmacytoma of the breast

Abstract

Two patients who presented initially with breast masses proven to be plasmacytomas, are described. In both cases the breast masses led to the diagnosis of multiple myeloma, which was retrospectively already present at the time of the breast biopsy. One patient with IgG lambda-type myeloma developed plasma cell leukemia and amyloidosis and failed to respond to radiochemotherapy. The second patient was in complete remission, four years after therapy, but has subsequently relapsed and died. All cases of breast plasmacytoma, described in the medical literatures are reviewed, and guidelines for future therapy are suggested.

Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

“…Breast plasmacytoma is one of the major differential diagnoses in synchronous diagnosis of breast cancer and multiple myeloma as plasmacytomas may mimic breast cancer in some cases, especially when axillary lymph nodes are involved. Few case reports have been published in the literature where breast plasmacytomas can occur either as a solitary lesion without evidence of systemic disease [ 4 – 7 ] or concurrently with multiple myeloma [ 8 – 11 ] or as a sign of relapse in patients with known history of myeloma [ 12 – 15 ].…”