Plasmacytoid Melanoma of the Urinary Bladder and Lymph Nodes with Immunohistochemical Expression of Plasma Cell Markers Revealing Primary Esophageal Melanoma

Ellouze, S.; Mnif, Héla; Amouri, A.; Khabir, Abdelmajid; Sellami‐Boudawara, Tahya

doi:10.1155/2012/916256

Cited by 9 publications

(9 citation statements)

References 14 publications

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“…However, histologically the tumor had features typical of plasmacytoma, which was also confirmed with MUM1 immunohistochemistry. Plasmacytoid melanoma comprised of cells expressing antigens characteristic of both tumors has been described in people, but MUM1 is absent in canine melanoma …”

Section: Discussionmentioning

confidence: 99%

“…Plasmacytoid melanoma comprised of cells expressing antigens characteristic of both tumors has been described in people, but MUM1 is absent in canine melanoma. 3,5 Additional stains to characterize the pigment showed a few cells positive with Prussian blue on cytology and histology preparations. Iron pigments have been identified rarely in benign and malignant plasma cells of people.…”

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? A pigmented round cell tumor

Quiroz-Rocha¹,

Deravi

Knight

et al. 2017

Veterinary Clinical Pathol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? A pigmented round cell tumor

Quiroz-Rocha¹,

Deravi

Knight

et al. 2017

Veterinary Clinical Pathol

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“…The plasma cell marker CD138 is commonly used in the diagnosis of plasma cell neoplasms such as multiple myeloma and extra-osseous plasmacytomas but has also been noted to be positive in occasional cases of plasmacytoid melanoma. 6 , 9 …”

Section: Discussionmentioning

confidence: 99%

Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation

et al. 2015

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Plasmacytoid melanoma is an unusual variant of malignant melanoma. The plasmacytoid morphology can be found in a variety of other malignancies including carcinomas, plasma cell neoplasms, lymphoproliferative disorders, and sarcomas. The authors report a rare case of plasmacytoid amelanotic malignant melanoma in a 78-year-old man presenting with an enlarging palpable, erythematous mass on his left posterior shoulder. A fine needle aspirate showed atypical findings with single amelanotic cells with high nuclear to cytoplasmic ratio, mono- and multi-nucleation with prominent nucleoli and intranuclear inclusions. Review of the excision and immunohistochemical analysis revealed the malignant plasmacytoid cells stained with vimentin, S-100, HMB-45, and other staining patterns consistent with melanoma. Initial evaluation was negative for other sites of disease. However, 4 months later, the patient was noted to have metastatic disease to his lungs and liver. Given that the tumor was noted to be BRAF V600R mutated, the patient was started on single agent dabrafenib. The plasmacytoid morphology can be found in a variety of malignancies. Melanoma should be considered in the differential diagnosis of any malignancy presenting with plasmacytoid features.

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“…Charfi et al [ 31 ] stated that plasmacytoid variant of melanoma is reported in only rare cases. They reported a 54-years-old man who was admitted because of enlarged lymph nodes in the lumbar region.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The diagnosis of metastatic plasmacytoid melanoma was finally established. Charfi et al [ 31 ] further stated the following. Clinical examination revealed an esophageal melanoma with melanosis which supported its primary location.…”

Section: Literature Reviewmentioning

confidence: 99%

Melanoma of the Urinary Bladder: A Review of the Literature

Venyo

2014

Surgery Research and Practice

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Background. Melanomas of the urinary bladder and urethra are rare. Aims. To review the literature on the disease. Methods. Various Internet databases were used to identify reported cases of the disease. Results. Less than 30 cases of primary melanoma of the urinary bladder and urethra have been reported in the literature and they have been associated with melanosis and commonly with metastases. The lesions may be primary or metastatic with no gender preference. The diagnostic features include pigmented raised lesions which histologically exhibit spindled or epitheliod cells, necrosis, mitotic figures, and atypical melanocytes. Immunohistochemically they stain positively with S100; HMB45; and other melanocyte markers, but negatively with Keratin and Vimentin. The treatment involves excision and possibly IL-2. The prognostic factors include size and depth of invasion as well as metastatic lesions. Conclusions. Less than 30 cases (about 24 cases) of the disease have been reported. There are also reports of metastatic melanomas of the urinary bladder emanating from primary melanomas originating elsewhere. Diagnosis of the primary disease is based upon the histological appearance of the lesion, positive staining with S100 and HMB45, and evidence of absence of melanoma elsewhere. Primary melanoma of the bladder is usually a fatal lesion.

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Plasmacytoid Melanoma of the Urinary Bladder and Lymph Nodes with Immunohistochemical Expression of Plasma Cell Markers Revealing Primary Esophageal Melanoma

Cited by 9 publications

References 14 publications

What is your diagnosis? A pigmented round cell tumor

What is your diagnosis? A pigmented round cell tumor

Amelanotic Melanoma Presenting with Plasmacytoid Morphology and BRAF V600 Mutation

Melanoma of the Urinary Bladder: A Review of the Literature

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