Plasmacytoid dendritic cells of the gut: Relevance to immunity and pathology

Lombardi, Vincent; Khaiboullina, Svetlana F.

doi:10.1016/j.clim.2014.04.007

Cited by 35 publications

(36 citation statements)

References 148 publications

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“…In the steady-state conditions, pDCs in Spl and MLNs expressed Siglec-H, CD62L, CXCR3, and C-C chemokine receptor 2 (CCR2) as well as CCR9 and a4b7, which are known as gut-homing receptors 35 ( Figure 4f and Supplementary Figure S3). Oral administration of DSS reduced the expression of CXCR3 and CD62L on MLN pDCs, whereas the expression of other molecules did not change ( Figure 4f and Supplementary Figure S3).…”

Section: Pdcs Accelerate Dss-induced Colonic Inflammationmentioning

confidence: 99%

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

et al. 2017

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Section: Pdcs Accelerate Dss-induced Colonic Inflammationmentioning

confidence: 99%

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

et al. 2017

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“…Upregulation of type I interferon (IFN) is essential to restrain HIV replication, especially at the early stages of infection [6]. The activation of IFN α expression occurs primarily through the engagement of toll-like receptors (TLR) 7 and 9 by single stranded RNA or CpG DNA, respectively (reviewed by [7]). It has been demonstrated that single nucleotide polymorphisms (SNPs) in TLRs are associated with an increased susceptibility to infection [8–11] and are involved in different progressions of HIV/AIDS, although a consensus has not been reached.…”

Section: Introductionmentioning

confidence: 99%

Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression

Анохин

Бахтеева

Хасанова

et al. 2016

BioMed Research International

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The genetic background of an individual plays an important role in the progression of HIV infection to AIDS. Identifying previously unknown or uncharacterized single nucleotide polymorphisms (SNPs) that associate with disease progression may reveal important therapeutic targets and provide a greater understanding of disease pathogenesis. In the present study, we employed ultra-high multiplex PCR on an Ion Torrent next-generation sequencing platform to sequence 23 innate immune genes from 94 individuals with HIV/AIDS. This data was used to identify potential associations of SNPs with clinical parameters and disease progression. SNPs that associated with an increased viral load were identified in the genes for the interleukin 15 receptor (IL15RA), toll-like receptor 7 (TLR7), tripartite motif-containing protein 5 (TRIM5), and two killer-cell immunoglobulin-like receptors (KIR2DL1 and KIR2DL3). Additionally, SNPs that associated with progression from HIV infection to AIDS were identified in two 2′-5′-oligoadenylate synthetase genes (OAS2 and OAS3). In contrast, other SNPs identified in OAS2 and OAS3 genes, as well as in the TRIM5 and KIR2DS4 genes, were associated with a slower progression of disease. Taken together, our data demonstrates the utility of ultra-high multiplex PCR in identifying polymorphisms of potential clinical significance and further,identifies SNPs that may play a role in HIV pathogenesis.

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“…They recognize microorganisms, distinguish among them, and are able to induce different responses even to closely related organisms. This ability to respond appropriately to different microbial products is particularly important in the gastrointestinal tract, where diverse microbial flora are located in close proximity to DC10.…”

mentioning

confidence: 99%

Structural and immunomodulatory differences among lactobacilli exopolysaccharides isolated from intestines of mice with experimentally induced inflammatory bowel disease

Górska

Sandström

Wojas-Turek

et al. 2016

Sci Rep

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Characteristic changes in the microbiota biostructure and a decreased tolerance to intestinal bacteria have been associated with inflammatory bowel disease (IBD). However, few studies have examined the constituents of the intestinal microbiota, including the surface molecules of the bacteria, in healthy and IBD subsets. Here, we compare the chemical structures and immunomodulatory properties of the exopolysaccharides (EPS) of lactobacilli isolated from mice with induced IBD (IBD “+”) versus those of healthy mice (IBD “−”). Classical structural analyses were performed using nuclear magnetic resonance spectroscopy and mass spectrometry. Immunomodulatory properties were assessed by stimulation of dendritic cells derived from mouse bone marrow or human peripheral mononuclear blood cells. Our results revealed that EPS produced by IBD “+” species are structurally different from those isolated from IBD “−”. Moreover, the structurally different EPS generate different immune responses by dendritic cells. We speculate that resident strains could, upon gut inflammation, switch to producing EPS with specific motifs that are absent from lactobacilli IBD “−”, and/or that bacteria with a particular EPS structure might inhabit the inflamed intestinal mucosa. This study may shed light on the role of EPS in IBD and help the development of a specific probiotic therapy for this disease.

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Plasmacytoid dendritic cells of the gut: Relevance to immunity and pathology

Cited by 35 publications

References 148 publications

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Crucial role of plasmacytoid dendritic cells in the development of acute colitis through the regulation of intestinal inflammation

Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression

Structural and immunomodulatory differences among lactobacilli exopolysaccharides isolated from intestines of mice with experimentally induced inflammatory bowel disease

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