Plasmacytoid Dendritic Cells in Pityriasis Rubra Pilaris

Abstract

Plasmacytoid dendritic cells (pDCs) are bone marrow-derived DCs with plasma cell morphology. They are lineage negative and express CD4, CD123, HLA-DR, blood-de

Updates on Pityriasis Rubra Pilaris: A Scoping Review

“…Al-Hage et al 14 employed immunohistochemical analysis of tissue from PRP patients to demonstrate an increased presence and activity of plasmacytoid dendritic cells, highlighting their potential role in PRP.…”

“…Moreover, there is evidence of significant overlap between psoriasis and PRP pathogenesis, supported by the success of psoriasis biologic agents when used for PRP treatment. 14 Further research should focus on identifying key molecules and cytokines involved in the pathogenesis of PRP. This could provide therapeutic targets for drug development and expand options for treatment.…”

“…Furthermore, levels seemed to correlate with PRP disease severity and responsiveness to IL-17A blockade treatment. 13 Al-Hage et al 14 employed immunohistochemical analysis of tissue from PRP patients to demonstrate an increased presence and activity of plasmacytoid dendritic cells, highlighting their potential role in PRP.…”

Updates and Proposed Diagnostic Approach to Psoriasiform Dermatoses

“…Neutrophils can be detected as intracorneal collections distributed in vertical tiers. The dermis may show superficial perivascular infiltrate 43 (TNF-alpha inhibitor) Dupilumab 44 (inhibitor of IL-4 and IL-13 for atopic dermatitis) Etanercept (TNF-alpha inhibitor) 18,45,46 Infliximab 47 (TNF-alpha inhibitor) Ixekizumab 48 (interleukin 17A for psoriasis) Ocrelizumab 49 (anti-CD20 antibody for multiple sclerosis) Immunomodulatory drugs Interferon-alpha-2b 50 Teriflunomide 51 (inhibitor of pyrimidine synthesis used for multiple sclerosis) Chemotherapy Doxorubicin 52 Mitomycin-C 53 Targeted anticancer drugs Durvalumab 54 (anti-PD1 monoclonal antibody) Nivolumab 55 (anti-PD1 monoclonal antibody) Pembrolizumab 56 (anti-PD1 monoclonal antibody) Sorafenib 57 (kinase inhibitor) Others Granulocyte colony-stimulating-factor 58 Fluorescein sodium used for fluorescein angiography 59 Topical imiquimod 60,61 of lymphocytes. 25,26 The histopathologic features are well demarcated and are often flanked by normal appearing skin.…”

“…Follicular plugging is also characteristic. 43,44 Sparse superficial perivascular infiltration can be seen, composed of mainly lymphocytes admixed with few plasma cells 45,46 and eosinophils. 45,47 Another distinctive feature is "shoulder parakeratosis," where parakeratosis is located along both sides of the hair follicle.…”