Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer

Charles, J.; Chaperot, Laurence; Salameire, Dimitri; Domizio, Jérémy Di; Aspord, Caroline; Gressin, Rémy; Jacob, Marie‐Christine; Marie-Jeanne, Richard; Béani, J.-C.; Plumas, Joël; Leccia, Marie‐Thérèse

doi:10.1684/ejd.2010.0816

Cited by 57 publications

(84 citation statements)

References 62 publications

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“…In this case, the host's immunity is forced to restrain the spread of the virus infection in the body by means of increasing type I IFN production and self antigen-driven immune cytotoxicity that is invariably associated with redundant tissue destruction. This concept is consistent with data suggesting that plasmacytoid dendritic cells play an important role in systemic lupus (Farkas et al 2001), psoriasis (Nestle et al 2005), and other autoimmune disorders (Charles et al 2010). These cells actively migrate and, following activation, produce large quantities of type 1 IFNs (Charles et al 2010).…”

Section: A Role For Toll-like Receptors (Tlrs) In Directing Autoimmunsupporting

confidence: 92%

“…TLRs are expressed on a wide variety of cell types throughout the body. Most notably, TLRs are located on immune cells such as dendritic cells, macrophages, T, and B cells where they play an important role in the detection of pathogens and enable their elimination from the body (Rakoff-Nahoum and Medzhitov 2008; Charles et al 2010).…”

Section: A Role For Toll-like Receptors (Tlrs) In Directing Autoimmunmentioning

confidence: 99%

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A balance between tissue-destructive and tissue-protective immunities: A role of toll-like receptors in regulation of adaptive immunity

Селедцов

Селедцова

2012

Immunobiology

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Section: A Role For Toll-like Receptors (Tlrs) In Directing Autoimmunsupporting

confidence: 92%

Section: A Role For Toll-like Receptors (Tlrs) In Directing Autoimmunmentioning

confidence: 99%

A balance between tissue-destructive and tissue-protective immunities: A role of toll-like receptors in regulation of adaptive immunity

Селедцов

Селедцова

2012

Immunobiology

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“…Interestingly, the only positively stained cell found in all the 51 examined slides was located in an area together with other inflammatory cells, illustrating the presence of pDC in inflamed, but not normal, uninflamed skin (18).…”

Section: Discussionmentioning

confidence: 89%

“…The presence of a third population, dermal plasmacytoid DC (pDC), in uninflamed skin is controversial, with some reports showing them to be present, while others do not (16)(17)(18). CLEC4C (CD303) expression is exclusive to pDC, which represent the main interferon-α-producing cells in the immune system and are considered to play a significant role in antiviral and anti-tumour immunity (19).…”

mentioning

confidence: 99%

CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

Sandvik

Skarstein²,

Sviland³

et al. 2014

Acta Derm Venerol

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The increased risk of squamous cell carcinomas (SCC) in renal transplant recipients (RTR) is related to impaired immunosurveillance as a consequence of immunosuppressive therapy. Since dendritic cells (DC) play an important role in immunosurveillance, we investigated the quantity of DC subsets and macrophages in normal skin of RTR and immunocompetent controls by immunohistochemistry. In this comparative study Langerhans' cells (LC) were present in similar numbers in RTR and controls. The number of CD11c+ DC was significantly reduced in RTR, particularly in patients on triple treatment therapy, compared with controls. Macrophages were significantly increased. Plasmacytoid DC were not detected in normal skin. The reduced quantity of CD11c+ DC and increased number of macrophages in normal skin of immunosuppressed RTR may contribute to the increased incidence of SCC in RTR. This finding underlines the role of DC subsets in immunosurveillance, and may have implications for our understanding of the effect of immunosuppression on DC subsets.

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“…cells in DM muscle biopsies are actually pDC, and de Padilla et al [14] also reported that high numbers of pDC are found in DM muscle tissue. However, although the role of pDC within a tumor is not as well known, an anti-tumor effect of pDC is hypothesized [15]. Therefore, although the etiology of DM in cancer patients is poorly understood, the disposition of tumor-bearing patients, coupled with the presence of pDC and (eventually) IFN-a, may contribute to the development of DM.…”

Section: Discussionmentioning

confidence: 99%

The association between dermatomyositis and papillary thyroid cancer: a case report

et al. 2011

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Hashimoto's thyroiditis (HT) is found in a high proportion of resected thyroid specimens. There has been considerable controversy as to whether having HT predisposes a patient to papillary thyroid cancer (PTC) and conflicting data have been reported with regard to Hashimoto thyroiditis (HT) and risk of malignancy. The aim of this study was to evaluate coexistence of papillary thyroid cancer (PTC) with HT. Materials and methods: This is a retrospective study done at American Hospital 2 from April 2011 until December 2013. We analyzed the data from 71 patients who underwent thyroid surgery at our institution. Of these, 29 patients were diagnosed with PTC. All patients diagnosed with PTC were evaluated for the presence of HT by measuring thyroid autoantibodies. If a patient had at least one positive thyroid autoantibody, then the patient was defined as having HT. Results: From a total of 71 patients who underwent thyroid surgery there were 29 patients diagnosed with PTC 3 males (10.3 %) and 26 females (89.7 %), mean age 41.9 (age 18-73) years old. Thyroid antibodies Ac Anti TPO and Ac Anti Thyroglobulin were measured in all patients with PTC. They were positive in six patients with PTC (20.6.8 %). They were all female patients. Conclusion: These data demonstrate that HT is associated with an increased risk of developing PTC. We also observed a high ratio of females diagnosed with PTC compared with males. An adequate follow up of patients with Hashimoto's thyroiditis may permit an early diagnosis of differentiated thyroid cancer and its appropriate management. More prospective

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Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer

Cited by 57 publications

References 62 publications

A balance between tissue-destructive and tissue-protective immunities: A role of toll-like receptors in regulation of adaptive immunity

A balance between tissue-destructive and tissue-protective immunities: A role of toll-like receptors in regulation of adaptive immunity

CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients

The association between dermatomyositis and papillary thyroid cancer: a case report

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