Plasmacytoïd dendritic cells acute leukemia: a case report

Bousquet, Aurore; Doutrelon, C.; Konopacki, Johanna; Marfaing-Koka, Anne; Segot, Amandine; Martinaud, Christophe; Samson, T.; Souleau, B.; Malfuson, Jean-Valère; Revel, Thierry de; Foissaud, Vincent

doi:10.1684/abc.2012.0752

Cited by 1 publication

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are so frequent after 50 years old but pediatric forms have been also described. The sex ratio is (3/1) with a male predominance [2]. We observe lymphadenopathy and/or splenomegaly in 61% of cases [2,3].…”

Section: Journal Of Leukemiamentioning

confidence: 72%

“…The sex ratio is (3/1) with a male predominance [2]. We observe lymphadenopathy and/or splenomegaly in 61% of cases [2,3]. Most of patients present cytopenia due to bone marrow infiltration; it is most often thrombocytopenia [4].…”

Section: Journal Of Leukemiamentioning

confidence: 77%

“…The recent individualization of this entity is probably not reflected an emerging disease. Rather it reflects the use of advanced diagnostic methods in current practice as flow cytometry to better characterize hematolymphoid neoplasm [2,12,13].…”

Section: Resultsmentioning

confidence: 99%

“…This leukemia is characterized by a systemic proliferation of plasmacytoid dendritic cells (PDC), with Immunophenotyping of surface coexpressing mostly CD4 and CD56. Its evolution is very aggressive with 16 months as median survival [2]. We present for discussion the rare and interesting case of patient presenting a LpDC after physical and biological exploration.…”

Section: Introductionmentioning

confidence: 94%

“…Its prognosis is poor, the median survival is less than 16 months, even for patients with pure cutaneous form. Relapses are common and early with frequent neuromeningeal attacks [2,10,11].…”

Section: Journal Of Leukemiamentioning

confidence: 99%

See 4 more Smart Citations

Plasmocytoid Dendritic Cells Leukemia: A Rare Presentation

Tlamçani¹

2014

J Leuk

View full text Add to dashboard Cite

The plasmacytoid dendritic cells leukemia is a rare hematolymphoid neoplasm with a very poor prognosis, where skin involvement is common. It is a malignant proliferation developed at the expense of hematopoietic cells of the white blood cells, proximate to normal plasmacytoid dendritic cells. The phenotype of tumor cells initially described was CD4 + CD56 +, without T marker expression. CD56-forms have also been reported, even fewer without skin involvement. More specific markers are expressed by tumor cells: CD123, BDCA2, BDCA4. We report an unusual presentation of this entity, but without skin lesions. The diagnosis of plasmacytoid dendritic cells leukemia was made on the cytological and immunophenotypic data given. The patient refused treatment and left hospital against medical advice. He returned four weeks later to emergency in an array of septic shock, he died a few hours after admission. Discussion The nomenclature used to describe this entity (Blastic Dendritic Plasmacytoïd Cell Neoplasm (BPDCN) or derived leukemia of

show abstract

Section: Journal Of Leukemiamentioning

confidence: 72%