Plasmacytoid dendritic cell role in cutaneous malignancies

Saadeh, Dana; Kurban, Mazen; Abbas, Ossama

doi:10.1016/j.jdermsci.2016.05.008

Cited by 34 publications

(45 citation statements)

References 85 publications

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“…In the periphery, mouse pDCs express CC-chemokine receptor 9 (CCR9), LY49Q and SCA1 [26–28]. Human pDCs exhibit plasma cells morphology and express CD4, HLA-DR, CD123, and blood derived cell antigen-2 (BDCA-2), as well as Toll-like receptor (TLR) 7 and 9 within endosomal compartments but not CD11c [26, 28, 29]. Under homeostatic conditions, pDCs are found in small numbers in T cell areas of LNs and spleen, mucosal-associated tissues, thymus and liver.…”

Section: Overview Of the Origin And Types Of Dendritic Cells In Tumormentioning

confidence: 99%

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Dendritic cells in cancer: the role revisited

Veglia

Gabrilovich

2017

Current Opinion in Immunology

372

290

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Dendritic cells (DCs) with their potent antigen presenting ability are long considered as critical factor in antitumor immunity. Despite high potential in promoting antitumor responses, tumor-associated DCs are largely defective in their functional activity and can contribute to immune suppression in cancer. In recent years existence of immune suppressive regulatory DCs in tumor microenvironment was described. Monocytic myeloid derived suppressor cells (M-MDSCs) can contribute to the pool of tumor associated DCs by differentiating to inflammatory DCs (inf-DCs), which appear to have specific phenotype and is critical component of antitumor response. Here we examine the role of inf-DCs along with other DC subsets in the regulation of immune responses in cancer. These novel data expand our view on the role of DCs in cancer and may provide new targets for immunotherapy.

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Section: Overview Of the Origin And Types Of Dendritic Cells In Tumormentioning

confidence: 99%

“…The recruitment of pDCs to several tumors, such as ovarian, head and neck, breast and primary melanoma, is often associated with poor prognosis [29, 30]. Many studies have shown that tumor associated pDCs are immature and are defective in the production of type I IFN.…”

Section: Dysfunction In Cancermentioning

confidence: 99%

Dendritic cells in cancer: the role revisited

Veglia

Gabrilovich

2017

Current Opinion in Immunology

372

290

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“…Whether or not PDCs play a role in this worse prognosis still needs further clarification. However, local type IFN production is decreased in most cutaneous sarcoidosis in association with the patchy distribution of the PDCs, which according to some, suggests a role for PDCs similar to the one played by them in the immunologic tolerance of neoplastic conditions …”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides

Fernández-Flores

2019

J Cutan Pathol

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Introduction Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon‐producing dendritic cells that link the innate and the adaptative immune responses. They have also been related to tolerance to certain tumors such as melanoma. Materials and methods In this article, we examined for the presence of CD123+ PDC in six cases of granulomatous MF from our archives. Results We found clusters of 10 or more positive cells in three of six cases of granulomatous MF (two women and a man, in their sixth and seventh decade). Although in two of these three cases the granulomatous response was extensive, in the other, it only represented 10% of the infiltrate of the biopsy. In all three cases, the granulomas were epithelioid, sarcoidal type. Conclusions CD123+ PDC can be identified in granulomatous MF. The pathogenic and prognostic role of this finding requires further clarification.

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“…They express CD4, CD123, human leucocyte antigen (HLA)‐DR, blood‐derived dendritic cell antigen (BDCA)‐2, and Toll‐like receptor (TLR)7 and TLR9 within endosomal compartments. When activated, pDCs are capable of producing large quantities of type I IFNs against pathogenic agents or danger signals . In fact, pDCs are considered the main tissue source and the most potent producers of type I IFN, secreting up to 1000 times as much IFN‐α/β as other cell types .…”

mentioning

confidence: 99%

“…Plasmacytoid dendritic cells (pDCs) comprise a specialized DC population that exhibits plasma cell morphology. 6,7 They express CD4, CD123, human leucocyte antigen (HLA)-DR, blood-derived dendritic cell antigen (BDCA)-2, and Toll-like receptor (TLR)7 and TLR9 within endosomal compartments. When activated, pDCs are capable of producing large quantities of type I IFNs against pathogenic agents or danger signals.…”

mentioning

confidence: 99%