Plasmacytoid dendritic cell and type I interferons as possible explanation for clearance of longstanding warts during COVID‐19 in a transplant patient, reply to Erkayman et al

Saadeh, Dana; Kurban, Mazen; Abbas, Ossama

doi:10.1111/tid.13585

Cited by 6 publications

(6 citation statements)

References 7 publications

(18 reference statements)

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“…7 Clinical resolution of warts may be attributed to the systemic stimulation of plasmacytoid dendritic cells and subsequent synthesis of interferon type 1 following COVID-19 infection or vaccination. [5][6][7][8][9] Similar resolution has been observed after intralesional application of certain vaccines (MMR or BCG vaccines), as well as after systemic administration of HPV vaccines, possibly due to an upregulation of IFN-γ and IL-1 and a decrease in IL-10. 10 Though not targeted by current quadrivalent HPV vaccines, a significant regression of wart lesions has been observed in 77% of patients in the post-vaccine period, attributed mainly to the homology of L1 capsid protein amid HPV types, conferring cross-immunity protection.…”

Section: Regression Of Common Viral Warts In An Immunocompetent Child...supporting

confidence: 54%

Regression of common viral warts in an immunocompetent child and an immunosuppressed adult relative after mRNA BNT162b2 COVID‐19 vaccine

Tsilingiris

Katoulis

2022

Acad Dermatol Venereol

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Section: Regression Of Common Viral Warts In An Immunocompetent Child...supporting

confidence: 54%

Regression of common viral warts in an immunocompetent child and an immunosuppressed adult relative after mRNA BNT162b2 COVID‐19 vaccine

Tsilingiris

Katoulis

2022

Acad Dermatol Venereol

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“…Saadeh et al . 6 postulated that regression could be triggered by systemic activation of plasmacytoid dendritic cells during SARS‐CoV‐2 infection and associated with type I interferon production.…”

Section: Figurementioning

confidence: 99%

Regression of common viral warts after ChAdOx1‐S COVID‐19 vaccine

Płaszczyńska

Sławińska

Sobjanek

2021

Acad Dermatol Venereol

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“…Saadeh et al. speculated that systemic activation of plasmacytoid dendritic cells produces type I interferons, which triggers resolution of warts 16 . Płaszczyńska et al.…”

Section: Discussionmentioning

confidence: 99%

“…15 Saadeh et al speculated that systemic activation of plasmacytoid dendritic cells produces type I interferons, which triggers resolution of warts. 16 Płaszczyńska et al reported a case of regression of verruca vulgaris after receiving a ChAdOx1-S COVID-19 vaccine (AstraZeneca). 17 Indeed, it has been found that some vaccines (mumps, measles, rubella vaccine BCG) can be used to treat warts vulgaris.…”

Section: Erkayman Et Al Reported a Case Of Multiple Refractory Viral ...mentioning

confidence: 99%

A case of chronic kidney disease patient with rapid deterioration of renal function, hair loss, and spontaneous resolution of facial warts after COVID‐19 infection

Wu,

Gao,

Zhang

et al. 2024

Aging Medicine

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BackgroundIndividuals with pre‐existing chronic kidney disease (CKD) are at an increased risk of experiencing severe symptoms if infected with COVID‐19. This report presents the case of a patient with CKD who contracted COVID‐19 and subsequently experienced rapid deterioration of kidney function, hair loss, and spontaneous remission of facial warts.Case presentationA 60‐year‐old Chinese man with a decade‐long history of abnormal serum creatinine (Scr) levels and recently heightened fatigue sought treatment. The disease was previously managed and deemed resolved in 2020. However, when he contracted the novel coronavirus on December 20, 2022, he experienced persistent fatigue without other symptoms. In early January 2023, Scr levels was examined as more than 300 μmol/L. This was followed by hair loss, including eyebrows and lashes, and the spontaneous resolution of a longstanding facial wart. During this period, although the patient received kidney‐protecting drugs and a lifestyle optimization, Scr increased continuously and the disease eventually progressed to the uremic stage. As the patient still had relatively abundant urine volume, the patient chose peritoneal dialysis treatment. At a two‐month follow‐up, he had adhered to the CAPD protocol without complications and his hair had begun to regrow. After eight months, his hair had mostly regrown, and his Scr levels kept stable.ConclusionThis case may represent the inaugural instance of CKD patients experiencing rapid deterioration of renal function, hair loss, and spontaneous remission of common warts. The underlying mechanisms of this unique phenomenon warrant further researches and debate.

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Plasmacytoid dendritic cell and type I interferons as possible explanation for clearance of longstanding warts during COVID‐19 in a transplant patient, reply to Erkayman et al

Cited by 6 publications

References 7 publications

Regression of common viral warts in an immunocompetent child and an immunosuppressed adult relative after mRNA BNT162b2 COVID‐19 vaccine

Regression of common viral warts in an immunocompetent child and an immunosuppressed adult relative after mRNA BNT162b2 COVID‐19 vaccine

Regression of common viral warts after ChAdOx1‐S COVID‐19 vaccine

A case of chronic kidney disease patient with rapid deterioration of renal function, hair loss, and spontaneous resolution of facial warts after COVID‐19 infection

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