Plasmablastic lymphoma

Fernández-Álvarez, Rubén; Sancho, Juan‐Manuel; Ribera, Josep‐Marǐa

doi:10.1016/j.medcle.2016.11.027

Cited by 2 publications

(6 citation statements)

References 46 publications

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“…This lymphoma presents more frequently in men (80%) with a median age of 39–46 years. It is closely related to HIV infection, representing around 2–12% of HRL [ 108 , 109 , 110 , 111 , 112 ] and in most cases the cells are also infected by EBV (75–100%) [ 113 , 114 , 115 ].…”

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

“…Extranodal involvement is very frequent in PBL in PLWH (95% of cases) at diagnosis, and in these patients the lymphoma usually presents at advanced stages (III or IV) [ 108 , 109 , 112 , 115 , 120 , 129 ]. The oral cavity is the most frequent extranodal site (48–58%) [ 29 , 108 , 113 , 129 ].…”

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

“…In one study, PLWL with MYC gene rearrangements were associated with a 6-fold increased risk of death [ 130 ]. Patients with EBV-related PBL have a worse prognosis than EBV-negative cases [ 112 ]. The elevated incidence of EBV infection could be useful for the differential diagnosis with other B-cell neoplasm with similar features.…”

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

“…In this regard, the median CD4+ lymphocyte count at diagnosis is 63–165 cells/µL, indicating a status of important immunodeficiency ( Table 1 ) [ 26 , 131 , 132 ]. Low CD4+ lymphocyte counts and the absence of cART treatment prior to lymphoma are considered factors of worse prognosis [ 112 ]. The impact of EBV on the prognosis of PBL is controversial, with some studies not reporting an influence of EBV infection on OS [ 26 , 108 , 124 , 129 ], whereas others have reported better outcomes in EBV-positive than in EBV-negative PBL in PLWH [ 114 , 124 , 133 ].…”

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

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Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

Verdu-Bou

Tapia

Hernández-Rodríguez

et al. 2021

Cancers

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The incidence of lymphomas is increased in people living with HIV (PLWH). Aggressive B-cell non-Hodgkin lymphomas (NHLs) are the most common and are considered an AIDS-defining cancer (ADC). Although Hodgkin lymphoma (HL) is not considered an ADC, its incidence is also increased in PLWH. Among all HIV-related lymphomas (HRL), the prevalence of Epstein–Barr virus (EBV) is high. It has been shown that EBV is involved in different lymphomagenic mechanisms mediated by some of its proteins, contributing to the development of different lymphoma subtypes. Additionally, cooperation between both HIV and EBV can lead to the proliferation of aberrant B-cells, thereby being an additional lymphomagenic mechanism in EBV-associated HRL. Despite the close relationship between EBV and HRL, the impact of EBV on clinical aspects has not been extensively studied. These lymphomas are treated with the same therapeutic regimens as the general population in combination with cART. Nevertheless, new therapeutic strategies targeting EBV are promising for these lymphomas. In this article, the different types of HRL are extensively reviewed, focusing on the influence of EBV on the epidemiology, pathogenesis, clinical presentation, and pathological characteristics of each lymphoma subtype. Moreover, novel therapies targeting EBV and future strategies to treat HRL harboring EBV are discussed.

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Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

Section: Implications Of Epstein–barr Virus In the Different Hiv-related Lymphoma Typesmentioning

confidence: 99%

See 2 more Smart Citations

Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

Verdu-Bou

Tapia

Hernández-Rodríguez

et al. 2021

Cancers

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“…Patients with PBL have a poor prognosis, with median survival times shorter than 2 years. [ 2 , 4 ] To the best of our knowledge, the survival of recurrent PBL is worse. [ 2 , 5 , 6 ] Here, we report a case of HIV-negative PBL in a patient who had recurrence after ASCT, but achieved and maintained complete remission for 4-years after salvage allo-HSCT.…”

Section: Introductionmentioning

confidence: 99%

Allogeneic hematopoietic stem cell transplantation in a patient with HIV-negative recurrent plasmablastic lymphoma

Rong

Sheng

et al. 2021

Medicine

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Introduction: No standard guideline has been established for the treatment of plasmablastic lymphoma (PBL) and prognosis remains extremely poor, given that patients relapse early after chemotherapy and show resistance to commonly used cytostatic drugs. Patient concerns: We present the case of a 52-year-old HIV-negative man who presented with a mass at the left sternoclavicular joint. He had no significant comorbidities and no latent immunosuppression. Diagnosis: The largest lymph node measured was 36 × 19 mm. An excisional biopsy showed diffuse proliferation of large lymphoid cells which were positive for CD38 and CD138, but negative for CD20. He was diagnosed with stage IV PBL with a low IPI. Interventions: The patient was treated with four cycles of induction therapy with bortezomib, epirubicin and dexamethasone. He achieved complete remission. But 3 months after receiving consolidated autologous hematopoietic stem cell transplantation, he relapsed. Allogeneic hematopoietic stem cell transplantation was performed on the patient. Outcomes: The patient achieved remission again and there were no serious complications after allogeneic hematopoietic stem cell transplantation. This patient was followed up once every three months, and to date, he has been disease-free for more than 4 years. Conclusion: The survival of recurrent PBL after autologous hematopoietic stem cell transplantation is very poor. Salvage allogeneic hematopoietic stem cell transplantation may bring long-term survival opportunities for those patients. Further clinical studies are needed to explore the role of allogeneic hematopoietic stem cell transplantation in refractory and recurrent PBL.

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Plasmablastic lymphoma

Cited by 2 publications

References 46 publications

Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

Clinical and Therapeutic Implications of Epstein–Barr Virus in HIV-Related Lymphomas

Allogeneic hematopoietic stem cell transplantation in a patient with HIV-negative recurrent plasmablastic lymphoma

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