Plasmablastic lymphoma of visceral cranium, cervix and thorax in an HIV-negative woman

Masgala, Aikaterini; Christopoulos, Constantinos; Giannakou, Niki; Boukis, Haralambos; Papadaki, Theodora; Anevlavis, E.

doi:10.1007/s00277-007-0280-z

Cited by 27 publications

(18 citation statements)

References 14 publications

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“…These include the anus, 3,6,7 stomach, 7,11 colon, liver, 1,11 scrotum, 1 lung and pleura, 3,12 bone, and nasal and paranasal sinuses. 3,6,13,14 PBL is characterized histologically by cells with immature or blastoid morphology and a striking resemblance to immunoblasts. The cells demonstrate a unique antigenic profile in that they are negative for leukocyte common antigen (LCA) but express the well-known plasma cell markers CD38 and CD138.…”

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confidence: 99%

Plasmablastic lymphoma: Cytologic findings in 5 cases with unusual presentation

Reid-Nicholson

Kavuri

Üstün

et al. 2008

Cancer

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mentioning

confidence: 99%

Plasmablastic lymphoma: Cytologic findings in 5 cases with unusual presentation

Reid-Nicholson

Kavuri

Üstün

et al. 2008

Cancer

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“…Additionally, there are rare reports of PBL of the cervix and uterus. However, this is the first case of PBL diagnosed on Pap smear …”

Section: Discussionmentioning

confidence: 81%

A case of plasmablastic lymphoma diagnosed on liquid‐based pap test

Arce

Broadway

Somma

et al. 2013

Diagnostic Cytopathology

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Primary gynecological lymphomas are rare and difficult to diagnose with Pap test. Herein, we report an uncommon case of plasmablastic lymphoma in a 61-year-old female with human immunodeficiency virus that presents with vaginal bleeding. The following case report shows the cytological features on liquid-based Pap test, cell block studies with diagnostic immunohistochemistry, discussion of the diagnostic difficulties, and a literature review.

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“…The case presented here demonstrates that the distinction can be impossible. The cutaneous presentation and high proliferation index supported a diagnosis of PBL [3,4]. However, PBL is generally associated with HIV and EBV, which were negative in the patient presented here [1, 2, 5, 6].…”

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confidence: 77%

Cutaneous presentation of an aggressive plasmablastic neoplasm indiscriminate between lymphoma and myeloma

et al. 2014

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Dear Editor, The distinction between plasmablastic lymphoma (PBL) and plasmablastic myeloma (PBM) is challenging but clinically important, as both malignancies are aggressive and require different treatment approaches.A 68-year-old Caucasian man presented with a conglomerate of cutaneous nodules on his back (Fig. 1a). Physical examination revealed no other abnormality. He reported mild fatigue but denied B symptoms and bone pain. A biopsy showed a dermal infiltrate that was composed of atypical plasmablastic cells with prominent nucleoli (Fig. 1b, c). Upon immunohistochemistry ( Fig. 1d-f), the cells were positive for CD79a, CD38, MUM1, EMA, Vs38c and CD56 and negative for CD138, PAX5, CD20, cyclin D1, CD30 and CD3. The tumour cells showed kappa light chain restriction on in situ hybridization for light chain mRNA. Ki67 proliferation index was >90 %, and in situ hybridisation studies for EBER RNA were negative. Sternal and pelvic bone marrow biopsies showed 20 % infiltration with tumour cells. Full blood count, renal and hepatic function tests, serum calcium, albumin, LDH and immunoglobulin levels were normal. Serum protein electrophoresis showed raised alpha-1 and alpha-2 globulin fractions indicative of an inflammatory response but no paraprotein. Serum free light chain levels were within normal limits. HIV serology was negative.A fluorodeoxyglucose positron emission-computerised tomography (PET-CT) scan showed foci of increased skeletal uptake, a conglomerate plaque of intensely avid subcutaneous nodules overlying the T10-L1 vertebral bodies and diffuse heterogeneous marrow activity, but no abnormal lymph nodes or hepatosplenomegaly (Fig. 1g, h). The CT component of the scan and additional later CT scans demonstrated that the spinal lesions were not osteolytic (Supplementary Figure 1). Magnetic resonance imaging (MRI) showed subcutaneous nodules with several focal bone marrow lesions throughout the vertebral column (Fig. 1i).A diagnosis of plasmablastic neoplasm indiscriminate between PBL and PBM was made. Treatment with an antimyeloma regimen (cyclophosphamide, bortezomib and dexamethasone) resulted in minimal reduction of the size of the skin lesions after two treatment cycles, amounting to stable disease. Treatment with an anti-lymphoma regimen (gemcitabine, vinorelbine and dexamethasone) did not result in a discernible response. The patient's general condition deteriorated, and he died three months after diagnosis, presumed to be due to progressive disease.PBL and PBM are different disease entities. However, the distinction can be difficult as both morphology and immunophenotype of the tumour cells are largely identical [1,2]. The case presented here demonstrates that the distinction can be impossible. The cutaneous presentation and high proliferation index supported a diagnosis of PBL [3,4]. However, PBL is generally associated with HIV and EBV, which were negative in the patient presented here [1, 2, 5, 6]. Bone marrow involvement in the absence of lymphadenopathy, and CD56-positivity of the plasmablasts...

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Plasmablastic lymphoma of visceral cranium, cervix and thorax in an HIV-negative woman

Cited by 27 publications

References 14 publications

Plasmablastic lymphoma: Cytologic findings in 5 cases with unusual presentation

Plasmablastic lymphoma: Cytologic findings in 5 cases with unusual presentation

A case of plasmablastic lymphoma diagnosed on liquid‐based pap test

Cutaneous presentation of an aggressive plasmablastic neoplasm indiscriminate between lymphoma and myeloma

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