Plasmablastic Lymphoma Involving the Parotid Gland

Bishop, Justin A.; Westra, William H.

doi:10.1007/s12105-010-0168-4

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…To our knowledge, there are few previous case reports [4, 7-10] describing cytological findings of a neoplasm with some similarities to the current case study; however, the current case study is unique and may be the first case report being negative for HIV and EBV and positive for HHV-8 and presented by parotid swelling as an initial presentation.…”

Section: Discussion/conculsionmentioning

confidence: 52%

“…In addition to previously mentioned lymphomas, PBL should be included in the differential diagnosis of any high-grade malignant neoplasm with plasmablastic morphology. In our case involving the parotid gland, PBL should be differentiated from poorly differentiated salivary gland carcinoma, metastatic malignant melanoma, or a plasmacytoid variant of a myoepithelial neoplasm [7].…”

Section: Discussion/conculsionmentioning

confidence: 99%

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Cytological Diagnosis of Plasmablastic Lymphoma Involving the Parotid Gland: A Case Report with Review of the Literature

et al. 2021

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Plasmablastic lymphoma (PBL) is a rare subtype of non-Hodgkin’s lymphoma that is associated with acquired immunodeficiency syndrome (AIDS), characterized by its association with Epstein-Barr virus (EBV), aggressive nature, and plasmacytic/plasmablastic differentiation. PBL remains a therapeutic and diagnostic challenge. Diagnosis of PBL by fine-needle aspiration cytology (FNAC) is reported infrequently. We herein describe the cytodiagnosis of a rare case of HIV-negative PBL in a 58-year-old man without EBV infection presented by parotid swelling. The current case study highlights the cytomorphologic features that may help to distinguish PBL from other mimics. However, although the cytomorphologic features may suggest PBL, a definitive diagnosis requires additional studies including tissue biopsy and immunohistochemistry, in addition to biochemical investigations and radiological workup to establish the diagnosis and exclude similar conditions. In conclusion, FNAC is a very useful, simple, rapid and reliable procedure for diagnosis of the lymphoma. FNAC provided the earliest clue to diagnosis of PBL, which was later confirmed by tissue biopsy.

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Section: Discussion/conculsionmentioning

confidence: 52%

Section: Discussion/conculsionmentioning

confidence: 99%

Cytological Diagnosis of Plasmablastic Lymphoma Involving the Parotid Gland: A Case Report with Review of the Literature

et al. 2021

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“…Some cases of MALT lymphoma can present prominent plasma cell differentiation, and less commonly, monoclonal gammopathy. The differential diagnosis of these cases from other NHLs with plasmacytic differentiation or plasma cell neoplasms is very difficult [15,16]. Our case differentiate from small lymphocytic lymphoma (chronic lymphocytic leukemia) by negative CD5 and CD23, and differentiate from lymphoplasmacytic lymphoma by without involvement of bone marrow.…”

Section: Discussionmentioning

confidence: 76%

Primary Small B-cell Lymphoma (MALT Lymphoma) at Lingual Tonsil: A Case Report

Aslan

2014

BJMMR

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Aims: Primary non-Hodgkin's lymphomas of the oropharyngeal region are rare. We report a case of a small B-cell lymphoma (MALT lymphoma) involving base of tongue. The patient was successfully treated with wide excision of the lesion followed by radiotherapy. Presentation of Case: A 75-year-old female Caucasian patient was referred to our clinic with complaints of foreign body sensation in the throat and progressively worsening snoring over 4 months. Oropharyngeal examination revealed a 3x3-cm smooth mass originating from the left side of the base of tongue and moving with protrusion of the tongue. Excisional biopsy revealed a low-grade small B-cell lymphoma with lambda monoclonal plasmacytic differentiation [extranodal marginal zone lymphoma of mucosaassociated lymphoid tissue (MALT) with lambda monoclonal plasmacytic differentiation]. The neoplastic population was consisted of small lymphoid B-cells and lambda Case Studymonoclonal plasma cells. Lymphoid cells showed CD20(+), CD5(-), CD23(-), CD10(-), BCL-6(-), IgD(-), BCL-2(+). In the neoplasm were seen few mitoses, and cellular proliferation marker Ki-67 was approximately 15%. Magnetic resonance imaging of the head and neck showed a well-circumscribed solid mass originating from the base of left side tongue. Bone marrow aspiration biopsy showed no evidence of disease. Computerized tomographic scans of the thorax and magnetic resonance imaging of the abdomen showed no adenopathy. Tumor was determined to be at Stage I. Discussion and Conclusion: Primary non-Hodgkin's lymphomas involving oropharyngeal region should be considered in differential diagnosis of all lesions located in this region. To our knowledge, a case of small B-cell lymphoma of the base of the tongue is rarely reported. An appropriate evaluation of the clinical presentation along with histopathologic and immunohistochemical evaluation of biopsy specimen may aid in the diagnosis and effective treatment.

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“…This pattern of slow then rapid growth has been noted in cases of plasmablastic lymphoma as well, adding to the complexity of distinguishing these 2 closely presenting entities [ 31 , 32 , 42 ].…”

Section: Discussionmentioning

confidence: 92%

Multiple Myeloma with Extramedullary Parotid Plasmacytoma in a Person Living with HIV: A Case Report and Differential Diagnosis of a Parotid Mass

et al. 2023

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Patient: Female, 51-year-old Final Diagnosis: Multiple myeloma with extramedullary plasmacytoma of parotid gland Symptoms: Headache • weight loss • vision change • facial mass Clinical Procedure: Incisional biopsy Specialty: Head & Neck Surgery • Infectious Disease • Internal Medicine Objective: Challenging differential diagnosis Background: The differential diagnosis for a parotid mass is broad, including infectious, autoimmune, and neoplastic etiologies. In people with HIV, regardless of viral suppression or immune status, neoplastic causes are more common. This report describes the evaluation of a woman with a large parotid mass, with an ultimate diagnosis of multiple myeloma with extramedullary plasmacytoma. Case Report: A 51-year-old woman with HIV infection presented with headache, weight loss, and right facial mass that was present for 5 years but more rapidly enlarging in the prior year. CD4 count was 234 cells/mL, and HIV RNA was 10 810 copies/mL. Physical examination was significant for a large deforming right-sided facial mass, decreased sensation in the V1 and V2 distributions, and right-sided ophthalmoplegia and ptosis. MRI and PET/CT scan confirmed a metabolically active large parotid mass with extension into the cavernous sinus. An IgG kappa monoclonal spike was present on serum protein electrophoresis. Incisional biopsy of the facial mass showed atypical lymphoid cells with plasmablastic and plasmacytic morphology with a high mitotic rate and proliferation index. She was diagnosed with R-ISS stage II IgG kappa multiple myeloma with extramedullary plasmacytoma, and initiated on chemotherapy, radiation, and antiretroviral therapy. Conclusions: A rapidly enlarging parotid mass should prompt timely evaluation and biopsy for definitive diagnosis, particularly in immunocompromised patients, including people with HIV. Extramedullary plasmacytomas have a more aggressive disease process in people with HIV and are associated with high-risk multiple myeloma and progression, as seen in this patient.

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Plasmablastic Lymphoma Involving the Parotid Gland

Cited by 10 publications

References 8 publications

Cytological Diagnosis of Plasmablastic Lymphoma Involving the Parotid Gland: A Case Report with Review of the Literature

Cytological Diagnosis of Plasmablastic Lymphoma Involving the Parotid Gland: A Case Report with Review of the Literature

Primary Small B-cell Lymphoma (MALT Lymphoma) at Lingual Tonsil: A Case Report

Multiple Myeloma with Extramedullary Parotid Plasmacytoma in a Person Living with HIV: A Case Report and Differential Diagnosis of a Parotid Mass

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